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Protein

Beta-1 adrenergic receptor

Gene

ADRB1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138Agonist or antagonistBy similarity1
Binding sitei143Agonist or antagonistBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1 adrenergic receptor
Alternative name(s):
Beta-1 adrenoreceptor
Short name:
Beta-1 adrenoceptor
Gene namesi
Name:ADRB1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55ExtracellularBy similarityAdd BLAST55
Transmembranei56 – 84Helical; Name=1By similarityAdd BLAST29
Topological domaini85 – 93CytoplasmicBy similarity9
Transmembranei94 – 120Helical; Name=2By similarityAdd BLAST27
Topological domaini121 – 132ExtracellularBy similarityAdd BLAST12
Transmembranei133 – 154Helical; Name=3By similarityAdd BLAST22
Topological domaini155 – 172CytoplasmicBy similarityAdd BLAST18
Transmembranei173 – 196Helical; Name=4By similarityAdd BLAST24
Topological domaini197 – 222ExtracellularBy similarityAdd BLAST26
Transmembranei223 – 248Helical; Name=5By similarityAdd BLAST26
Topological domaini249 – 306CytoplasmicBy similarityAdd BLAST58
Transmembranei307 – 336Helical; Name=6By similarityAdd BLAST30
Topological domaini337 – 341ExtracellularBy similarity5
Transmembranei342 – 364Helical; Name=7By similarityAdd BLAST23
Topological domaini365 – 467CytoplasmicBy similarityAdd BLAST103

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691151 – 467Beta-1 adrenergic receptorAdd BLAST467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi15N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi131 ↔ 216PROSITE-ProRule annotation
Disulfide bondi209 ↔ 215PROSITE-ProRule annotation
Lipidationi380S-palmitoyl cysteineBy similarity1
Modified residuei415PhosphoserineBy similarity1

Post-translational modificationi

Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ9TT96.
PRIDEiQ9TT96.

Interactioni

Subunit structurei

Interacts (via C-terminus PDZ motif) with RAPGEF2; the interaction is direct. Interacts with GOPC, MAGI3 and DLG4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001639.

Structurei

3D structure databases

ProteinModelPortaliQ9TT96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni218 – 232Agonist and antagonist bindingBy similarityAdd BLAST15
Regioni324 – 331Agonist and antagonist bindingBy similarity8
Regioni350 – 354Agonist and antagonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi464 – 467PDZ-BindingBy similarity4

Domaini

The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ9TT96.
KOiK04141.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000507. ADRB1_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00561. ADRENRGCB1AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TT96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGVLALGA SEPCNLSSAA PVPDGAATAA RLLVPASPPA SLLTSASEGP
60 70 80 90 100
PLPSQQWTAG MGLLMAFIVL LIVVGNVLVL VAIAKTPRLQ TLTNLFIMSL
110 120 130 140 150
ASADLVMGLL VVPFGATIVV WGRWEYGSFF CELWTSVDVL CVTASIETLC
160 170 180 190 200
VIALDRYLAI TSPFRYQSLL TRARARALVC TVWAISALVS FLPIFMQWWG
210 220 230 240 250
DKDAKASRCY NDPECCDFII NEGYAITSSV VSFYVPLCIM AFVYLRVFRE
260 270 280 290 300
AQKQVKKIDS CERRFLSGPA RLPSPAPSPG PPLPAATVAN GRANKRRPPR
310 320 330 340 350
LVALREQKAL KTLGIIMGVF TLCWLPFFLA NVVKAFHRDL VPDRLFVFFN
360 370 380 390 400
WLGYANSAFN PIIYCRSPDF RKAFQRLLCC ARRAACGSHA AAGDPPRALG
410 420 430 440 450
CLAVARPSPS PGAASDDDDD DDEDDVGAAP PVRLLEPWAG YNGGAAANSD
460
SSPDEPSRAG CASESKV
Length:467
Mass (Da):50,137
Last modified:December 1, 2000 - v2
Checksum:iD929E79ADDF4039F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122G → D in AAF21435 (Ref. 1) Curated1
Sequence conflicti156R → H in AAF21435 (Ref. 1) Curated1
Sequence conflicti200G → R in AAF21435 (Ref. 1) Curated1
Sequence conflicti208R → G in AAF21435 (Ref. 1) Curated1
Sequence conflicti235V → A in AAF21435 (Ref. 1) Curated1
Sequence conflicti299P → S in AAF21435 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188187 Genomic DNA. Translation: AAF21435.1.
AF095852 Genomic DNA. Translation: AAF01674.1.
RefSeqiNP_919242.1. NM_194266.1.
UniGeneiBt.79981.

Genome annotation databases

GeneIDi281604.
KEGGibta:281604.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188187 Genomic DNA. Translation: AAF21435.1.
AF095852 Genomic DNA. Translation: AAF01674.1.
RefSeqiNP_919242.1. NM_194266.1.
UniGeneiBt.79981.

3D structure databases

ProteinModelPortaliQ9TT96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001639.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ9TT96.
PRIDEiQ9TT96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281604.
KEGGibta:281604.

Organism-specific databases

CTDi153.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ9TT96.
KOiK04141.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000507. ADRB1_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00561. ADRENRGCB1AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADRB1_BOVIN
AccessioniPrimary (citable) accession number: Q9TT96
Secondary accession number(s): Q9TUB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.