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Q9TT94 (ACOD_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acyl-CoA desaturase

EC=1.14.19.1
Alternative name(s):
Delta(9)-desaturase
Short name=Delta-9 desaturase
Fatty acid desaturase
Stearoyl-CoA desaturase
Gene names
Name:SCD
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O2 and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA By similarity.

Catalytic activity

Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.

Cofactor

Iron.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Probable.

Domain

The histidine box domains may contain the active site and/or be involved in metal ion binding.

Sequence similarities

Belongs to the fatty acid desaturase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Acyl-CoA desaturase
PRO_0000185394

Regions

Topological domain1 – 7171Cytoplasmic Potential
Transmembrane72 – 9322Helical; Potential
Topological domain94 – 1029Lumenal Potential
Transmembrane103 – 11917Helical; Potential
Topological domain120 – 21697Cytoplasmic Potential
Transmembrane217 – 23519Helical; Potential
Topological domain236 – 25015Lumenal Potential
Transmembrane251 – 27323Helical; Potential
Topological domain274 – 35986Cytoplasmic Potential
Motif120 – 1256Histidine box-1
Motif157 – 1615Histidine box-2
Motif298 – 3025Histidine box-3

Amino acid modifications

Modified residue2031Phosphoserine By similarity

Experimental info

Sequence conflict51L → M in AAF22305. Ref.1
Sequence conflict2931A → V in AAF22305. Ref.1
Sequence conflict2931A → V in AAL99940. Ref.2
Sequence conflict3561Y → H in AAF22305. Ref.1
Sequence conflict3591G → S in AAF22305. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9TT94 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: C7C9E9FA3A8FD205

FASTA35941,705
        10         20         30         40         50         60 
MPAHLLQEEI SSSYTTTTTI TAPPSRVLQN GGGKLEKTPL YLEEDIRPEM RDDIYDPTYQ 

        70         80         90        100        110        120 
DKEGPKPKLE YVWRNIILMS LLHLGALYGI TLIPTCKIYT YIWVLFYYLM GALGITAGAH 

       130        140        150        160        170        180 
RLWSHRTYKA RLPLRVFLII GNTMAFQNDV FEWSRDHRAH HKFSETDADP HNSRRGFFFS 

       190        200        210        220        230        240 
HVGWLLVRKH PAVKEKGSTL NLSDLRAEKL VMFQRRYYKP GVLLLCFILP TLVPWYLWDE 

       250        260        270        280        290        300 
TFQNSLFFAT LFRYALGLNV TWLVNSAAHM YGYRPYDKTI NPRENILVSL GAAGEGFHNY 

       310        320        330        340        350 
HHTFPYDYSA SEYRWHINFT TFFIDCMAAI GLAYDRKKVS KAAILARIKR TGEESYKSG 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of bovine stearoyl CoA desaturasel cDNA from adipose tissues."
Chung M.I., Ha S.H., Jeong S., Bok J., Cho K., Baik M.G., Choi Y.J.
Biosci. Biotechnol. Biochem. 64:1526-1530(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Adipose tissue.
[2]"Bovine stearoyl-CoA desaturase gene structure and large scale SNP analysis."
Glimm D., Dong F., Kennelly J.
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Genomic structure and expression of the bovine stearoyl-CoA desaturase gene."
Medrano J.F., Islas-Trejo A.D., Johnson A.M., DePeters E.J.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[4]NIH - Mammalian Gene Collection (MGC) project
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hypothalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF188710 mRNA. Translation: AAF22305.1.
AF481919 expand/collapse EMBL AC list , AF481915, AF481916, AF481917, AF481918 Genomic DNA. Translation: AAL99940.1.
AY241932 Genomic DNA. Translation: AAO63569.1.
AY241933 mRNA. Translation: AAO63570.1.
BC112700 mRNA. Translation: AAI12701.1.
PIRPC7092.
RefSeqNP_776384.3. NM_173959.4.
UniGeneBt.65021.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID280924.
KEGGbta:280924.

Organism-specific databases

CTD6319.

Phylogenomic databases

HOVERGENHBG003367.
KOK00507.

Family and domain databases

InterProIPR005804. Fatty_acid_desaturase-1.
IPR001522. Fatty_acid_desaturase-1_C.
IPR015876. Fatty_acid_desaturase-1_core.
[Graphical view]
PfamPF00487. FA_desaturase. 1 hit.
[Graphical view]
PRINTSPR00075. FACDDSATRASE.
PROSITEPS00476. FATTY_ACID_DESATUR_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805045.

Entry information

Entry nameACOD_BOVIN
AccessionPrimary (citable) accession number: Q9TT94
Secondary accession number(s): Q861R6, Q8SQ76
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: June 27, 2006
Last modified: February 19, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families