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Protein

Sodium/potassium-transporting ATPase subunit beta-1

Gene

ATP1B1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity).By similarity
Involved in cell adhesion and establishing epithelial cell polarity.By similarity

GO - Molecular functioni

  • ATPase binding Source: BHF-UCL
  • nitric-oxide synthase binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processCell adhesion, Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandPotassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1
Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-1
Gene namesi
Name:ATP1B1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34CytoplasmicSequence analysisAdd BLAST34
Transmembranei35 – 62Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST28
Topological domaini63 – 303ExtracellularSequence analysisAdd BLAST241

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002659581 – 303Sodium/potassium-transporting ATPase subunit beta-1Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineBy similarity1
Modified residuei101PhosphotyrosineBy similarity1
Disulfide bondi126 ↔ 149By similarity
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi159 ↔ 175By similarity
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi213 ↔ 276By similarity
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glutathionylated.By similarity

Keywords - PTMi

Disulfide bond, Glutathionylation, Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with regulatory subunit FXYD1 (By similarity). Interacts with regulatory subunit FXYD3 (PubMed:21454534). Interacts with NKAIN1, NKAIN2 and NKAIN4 (By similarity). Interacts with MLC1 (By similarity). Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM (By similarity). Interacts with KIRREL3 (By similarity). Interacts with OBSCN (via protein kinase domain 1) (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ATP1A1Q9N0Z62EBI-9685670,EBI-9685690

GO - Molecular functioni

  • ATPase binding Source: BHF-UCL
  • nitric-oxide synthase binding Source: BHF-UCL

Protein-protein interaction databases

IntActiQ9TT37. 3 interactors.
STRINGi9986.ENSOCUP00000005938.

Structurei

3D structure databases

ProteinModelPortaliQ9TT37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni191 – 303immunoglobulin-likeBy similarityAdd BLAST113

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiQ9TT37.
KOiK01540.

Family and domain databases

InterProiView protein in InterPro
IPR000402. Na/K_ATPase_sub_beta.
IPR015565. Na/K_ATPase_sub_beta_chordates.
PANTHERiPTHR11523. PTHR11523. 1 hit.
PTHR11523:SF10. PTHR11523:SF10. 1 hit.
PfamiView protein in Pfam
PF00287. Na_K-ATPase. 1 hit.
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiView protein in PROSITE
PS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9TT37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGKAKEEG SWKKFIWNSE KKEFLGRTGG SWFKILLFYV IFYGCLAGIF
60 70 80 90 100
IGTIQVMLLT ISEFKPTYQD RVAPPGLTQV PQIQKTEIAF RPSDPKSYEE
110 120 130 140 150
YVVNIVRFLE KYKDSAQKDD MVFEDCGDVP SEPKERGEFN NERGQRKVCR
160 170 180 190 200
FKLNWLGNCS GIDDETYGYK DGKPCIIIKL NRVLGFKPKP PKNDSLEFSP
210 220 230 240 250
GTKYNPNVLP VQCTGKRDED KEKVGSMEYF GMGDYAGFPL QYYPYYGKLL
260 270 280 290 300
QPKYLQPLLA VQFTNLTMDT EIRIECKAYG ENIGYSEKDR FQGRFDVKIE

VKS
Length:303
Mass (Da):34,940
Last modified:May 1, 2000 - v1
Checksum:iC1908DBE392E584F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204927 mRNA. Translation: AAF18134.1.
RefSeqiNP_001075542.1. NM_001082073.1.
UniGeneiOcu.2403.

Genome annotation databases

GeneIDi100008749.
KEGGiocu:100008749.

Similar proteinsi

Entry informationi

Entry nameiAT1B1_RABIT
AccessioniPrimary (citable) accession number: Q9TT37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families