Q9TSZ7 (GCST_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase, mitochondrial
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein
Short name=GCVT

Gene names

Name:

AMT

Organism

Canis familiaris (Dog) (Canis lupus familiaris)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	403 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity.
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 28	28	Mitochondrion By similarity
	Chain	29 – 403	375	Aminomethyltransferase, mitochondrial		PRO_0000010754

Sequences

	Sequence		Length	Mass (Da)
	Q9TSZ7 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: F12B8B9AE79FB8B8	FASTA	403	43,652
	10 20 30 40 50 60 MQRAMTVVPH LGLRLQALPL ALGRPLSRAQ DVLRRTPLYD FHLAHGGKMV AFAGWSLPVQ 70 80 90 100 110 120 YRDSHVDSHL HTRRHCSLFD VSHMLQTKIL GCDRVKLMES LVVGDIAELR PNQGTLSLFT 130 140 150 160 170 180 NEAGGIEDDL IVTSTSEGYL YVVSNAGCWD KDLALMQGKV RELQNMGSDV SLEVVDNALL 190 200 210 220 230 240 ALQGPTATQV LQAGVADDLR KLPFMTSAVM EVFGVSGCRV TRCGYTGEDG VEISVPAAAA 250 260 270 280 290 300 VRLAAALLEN PEVKLAGLAA RDSLRLEAGL CLYGSDIDEH TTPVEGSLSW TLGKRRRAAM 310 320 330 340 350 360 DFPGASVIIA QLKGKVQRRR VGLTCEGAPV RAHSPILNME GTVIGTVTSG CPSPCLKKNV 370 380 390 400 AMGYVPSEYS RPGTPLLVEV RRKQQMAVVS KMPFVTTNYY TLK

References

[1]	"Genomic structures and sequences of two closely linked genes (AMT,TCTA) on dog chromosome 20q15.1-q15.2." Leeb T., Breen M., Brenig B. Cytogenet. Cell Genet. 89:98-100(2000) [PubMed: 10894947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ012166 Genomic DNA. Translation: CAB62567.1.
RefSeq	NP_001029165.1. NM_001033993.1.
UniGene	Cfa.11059.
3D structure databases
ProteinModelPortal	Q9TSZ7.
SMR	Q9TSZ7. Positions 32-402.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9TSZ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSCAFT00000018228; ENSCAFP00000016880; ENSCAFG00000011489.
GeneID	484770.
KEGG	cfa:484770.
Organism-specific databases
CTD	275.
Phylogenomic databases
eggNOG	maNOG04671.
GeneTree	ENSGT00510000047333.
HOVERGEN	HBG005822.
InParanoid	Q9TSZ7.
OMA	RITRCGY.
PhylomeDB	Q9TSZ7.
Family and domain databases
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_CANFA

Accession

Primary (citable) accession number: Q9TSZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	November 16, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program