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Protein

Potassium voltage-gated channel subfamily H member 2

Gene

KCNH2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi741 – 858118cNMPAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 2
Alternative name(s):
Ether-a-go-go-related gene potassium channel 1
Short name:
DERG
Short name:
ERG-1
Short name:
Eag-related protein 1
Short name:
Ether-a-go-go-related protein 1
Short name:
c-ERG
Voltage-gated potassium channel subunit Kv11.1
Gene namesi
Name:KCNH2
Synonyms:CERG, ERG
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 402402CytoplasmicSequence analysisAdd
BLAST
Transmembranei403 – 42321Helical; Name=Segment S1Sequence analysisAdd
BLAST
Topological domaini424 – 44926ExtracellularSequence analysisAdd
BLAST
Transmembranei450 – 47021Helical; Name=Segment S2Sequence analysisAdd
BLAST
Topological domaini471 – 49424CytoplasmicSequence analysisAdd
BLAST
Transmembranei495 – 51521Helical; Name=Segment S3Sequence analysisAdd
BLAST
Topological domaini516 – 5194ExtracellularSequence analysis
Transmembranei520 – 54021Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd
BLAST
Topological domaini541 – 5466CytoplasmicSequence analysis
Transmembranei547 – 56721Helical; Name=Segment S5Sequence analysisAdd
BLAST
Topological domaini568 – 61043ExtracellularSequence analysisAdd
BLAST
Intramembranei611 – 63121Pore-forming; Name=Segment H5Sequence analysisAdd
BLAST
Topological domaini632 – 6376ExtracellularSequence analysis
Transmembranei638 – 65821Helical; Name=Segment S6Sequence analysisAdd
BLAST
Topological domaini659 – 1158500CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3085616.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11581158Potassium voltage-gated channel subfamily H member 2PRO_0000053997Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei179 – 1791PhosphoserineBy similarity
Modified residuei239 – 2391PhosphoserineBy similarity
Modified residuei283 – 2831PhosphoserineBy similarity
Modified residuei284 – 2841PhosphoserineBy similarity
Modified residuei319 – 3191PhosphoserineBy similarity
Modified residuei350 – 3501PhosphoserineBy similarity
Glycosylationi597 – 5971N-linked (GlcNAc...)Sequence analysis
Modified residuei870 – 8701PhosphoserineBy similarity
Modified residuei873 – 8731PhosphoserineBy similarity
Modified residuei889 – 8891PhosphoserineBy similarity
Modified residuei1136 – 11361PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated on serine and threonine residues.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9TSZ3.

Expressioni

Tissue specificityi

Highly expressed in left and right atria of the heart, in cortex and hippocampus; detected at intermediate levels in left and right ventricle, Purkinje fibers, cerebellum, thalamus and basal ganglia; detected at low levels in liver, spleen and kidney.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH6/ERG2 and KCNH7/ERG3 (By similarity). Interacts with ALG10B (By similarity). Heteromultimer with KCNE1 and KCNE2 (By similarity). Interacts with CANX (By similarity). The core-glycosylated, but not the fully glycosylated form interacts with RNF207 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000035370.

Chemistry

BindingDBiQ9TSZ3.

Structurei

3D structure databases

ProteinModelPortaliQ9TSZ3.
SMRiQ9TSZ3. Positions 26-135, 569-610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 8872PASPROSITE-ProRule annotationAdd
BLAST
Domaini92 – 14453PACPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi623 – 6286Selectivity filterBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi296 – 2994Poly-Pro

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 PAC (PAS-associated C-terminal) domain.PROSITE-ProRule annotation
Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0498. Eukaryota.
ENOG410XPSE. LUCA.
HOGENOMiHOG000230793.
HOVERGENiHBG052232.
InParanoidiQ9TSZ3.
KOiK04905.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003967. K_chnl_volt-dep_ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01470. ERGCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TSZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVRRGHVAP QNTFLDTIIR KFEGQSRKFI IANARVENCA VIYCNDGFCE
60 70 80 90 100
LCGYSRAEVM QRPCTCDFLH GPRTQRRAAA QIAQALLGAE ERKVEIAFYR
110 120 130 140 150
KDGSCFLCLV DVVPVKNEDG AVIMFILNFE VVMEKDMVGS PTHDTNHRGP
160 170 180 190 200
PTSWLAPGRA KTFRLKLPAL LALTTRESSA RPGGVGSAGA PGAVVVDVDL
210 220 230 240 250
SPAVPSRESL ALDEVTAMDN HVAGLGPMEE QRALVGSSSP PAGAPEPLPS
260 270 280 290 300
PRAHSLNPDA SGSSCSLART RSRESCASVR RASSADDIEA MRAGLPPPPR
310 320 330 340 350
HASTGAMHPL RGGLLNSTSD SDLVRYRTIS KIPQITLNFV DLKGDPFLAS
360 370 380 390 400
PTSDREIIAP KIKERTHNVT EKVTQVLSLG ADVLPEYKLQ APRIHRWTIL
410 420 430 440 450
HYSPFKAVWD WLILLLVIYT AVFTPYSAAF LLKETEEGPP APDCGYACQP
460 470 480 490 500
LAVVDFIVDI MFIVDILINF RTTYVNANEE VVSHPGRIAV HYFKGWFLID
510 520 530 540 550
MVAAIPFDLL IFGSGSEELI GLLKTARLLR LVRVARKLDR YSEYGAAVLF
560 570 580 590 600
LLMCTFALIA HWLACIWYAI GNMEQPHMDS RIGWLHNLGD QIGKPYNSSG
610 620 630 640 650
LGGPSIKDKY VTALYFTFSS LTSVGFGNVS PNTNSEKIFS ICVMLIGSLM
660 670 680 690 700
YASIFGNVSA IIQRLYSGTA RYHTQMLRVR EFIRFHQIPN PLRQRLEEYF
710 720 730 740 750
QHAWSYTNGI DMNAVLKGFP ECLQADICLH LNRSLLQHCK PFRGATKGCL
760 770 780 790 800
RALAMKFKTT HAPPGDTLVH AGDLLTALYF ISRGSIEILR GDVVVAILGK
810 820 830 840 850
NDIFGEPLNL YARPGKSNGD VRALTYCDLH KIHRDDLLEV LDMYPEFSDH
860 870 880 890 900
FWSSLEITFN LRDTNMIPGS PGSAELEGGF NRQRKRKLSF RRRTDRDPEQ
910 920 930 940 950
PGEVSALGPG RAGAGPSGRG RPGGPWGESP SSGPSSPESS EDEGPGRSSS
960 970 980 990 1000
PLRLVPFSSP RPPGEPPGGE PLTEDGEKSS DTCNPLSGAF SGVSNIFSFW
1010 1020 1030 1040 1050
GDSRGHQYQE LPRCPAPTPS LLNIPLSSPC RRPRGDVEGR LDALQRQLNR
1060 1070 1080 1090 1100
LETRLSADMA TVLQLLQRQM TLIPPAYSAV TTPGPGPTST SSLLPVSPIP
1110 1120 1130 1140 1150
TLTLDSLSQV SQFMAFEELP PGAPELPQDG PPRRLSLPGQ LGALTSQPLH

RHGSDPGS
Length:1,158
Mass (Da):126,645
Last modified:May 1, 2000 - v1
Checksum:i53C849032B4AA3D0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti442 – 4421P → T in AAC48722 (PubMed:9012748).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243344 mRNA. Translation: CAB64868.1.
U75213 mRNA. Translation: AAC48722.1.
AF017429 mRNA. Translation: AAB70524.1.
RefSeqiNP_001003145.1. NM_001003145.1.
UniGeneiCfa.3625.

Genome annotation databases

GeneIDi403761.
KEGGicfa:403761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243344 mRNA. Translation: CAB64868.1.
U75213 mRNA. Translation: AAC48722.1.
AF017429 mRNA. Translation: AAB70524.1.
RefSeqiNP_001003145.1. NM_001003145.1.
UniGeneiCfa.3625.

3D structure databases

ProteinModelPortaliQ9TSZ3.
SMRiQ9TSZ3. Positions 26-135, 569-610.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000035370.

Chemistry

BindingDBiQ9TSZ3.
ChEMBLiCHEMBL3085616.

Proteomic databases

PaxDbiQ9TSZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403761.
KEGGicfa:403761.

Organism-specific databases

CTDi3757.

Phylogenomic databases

eggNOGiKOG0498. Eukaryota.
ENOG410XPSE. LUCA.
HOGENOMiHOG000230793.
HOVERGENiHBG052232.
InParanoidiQ9TSZ3.
KOiK04905.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003967. K_chnl_volt-dep_ERG.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01470. ERGCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKCNH2_CANLF
AccessioniPrimary (citable) accession number: Q9TSZ3
Secondary accession number(s): O02719, O18820
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.