Reviewed, UniProtKB/Swiss-Prot Q9TSZ1 (RENI_CALJA)

Names and origin

Protein names

Recommended name:
    Renin
    EC=3.4.23.15
Alternative name(s):
    Angiotensinogenase

Gene names

Name:

REN

Organism

Callithrix jacchus (Common marmoset)

Taxonomic identifier

9483 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Cebidae › Callitrichinae › Callithrix

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney By similarity.
Catalytic activity	Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.
Enzyme regulation	Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing By similarity.
Subunit structure	Interacts with ATP6AP2 By similarity.
Subcellular location	SecretedBy similarity. MembraneBy similarity. Note= Associated to membranes via binding to ATP6AP2 By similarity.
Sequence similarities	Belongs to the peptidase A1 family.

Ontologies

Keywords
Cellular component	Membrane Secreted
Domain	Signal
Molecular function	Aspartyl protease Hydrolase Protease
PTM	Glycoprotein Zymogen
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-KW membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	By similarity
	Propeptide	24 – 60	37	Activation peptide		PRO_0000026077
	Chain	61 – 400	340	Renin		PRO_0000026078
Sites
	Active site	98	1	By similarity
	Active site	286	1	By similarity
Amino acid modifications
	Glycosylation	65	1	N-linked (GlcNAc...) Potential
	Glycosylation	135	1	N-linked (GlcNAc...) Potential
	Disulfide bond	111 ↔ 118		By similarity
	Disulfide bond	277 ↔ 281		By similarity
	Disulfide bond	319 ↔ 356		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9TSZ1-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 31769217035615FA	FASTA	400	44,038
	10 20 30 40 50 60 MDAWRGMPRW GLLLLLWGSC TFGLPTETTT FKRISLKRMP SIRESLKERG VDMARLGPER 70 80 90 100 110 120 MALVNITSSV ILTNYMDTQY YGEIGIGTPP QTFKVVFDTG SSNVWVPSSK CSRLYTACVY 130 140 150 160 170 180 HKLFDASDSS SYKHNGTELT LRYSTGTVSG FLSQDVITVG GITVTQTFGE VTEMPALPFM 190 200 210 220 230 240 LAEFDGVVGM GFSEQAIGKV TPLFDNIISQ GLLKEDVFSF YYNRDSENSQ SLGGQIVLGG 250 260 270 280 290 300 SDPQHYEGNF HYINLIRTGL WQIPMKGVSV GSSTLLCEDG CLALVDTGAS YISGSTSSIE 310 320 330 340 350 360 KLMEALGAKK RLFDYVVKCN EGPTLPDISF HLGGKEYTLT SADYVFQESY SSKKLCTLAI 370 380 390 400 HAMDIPPPTG PTWALGATFI RKFYTEFDRG NNRIGFALAR

References

[1]	"Cloning and characterization of marmoset renin: comparison with human renin." Valdenaire O., Breu V., Giller T., Bur D., Fischli W. J. Cardiovasc. Pharmacol. 34:893-897(1999) [PubMed: 10598135] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ132342 mRNA. Translation: CAB64879.1.
3D structure databases
HSSP	HSSP built from PDB template 1HRN based on UniProtKB P00797.
SMR	Q9TSZ1. Positions 65-400.
ModBase	Search...
Protein family/group databases
MEROPS	A01.007.
Phylogenomic databases
HOVERGEN	Q9TSZ1.
Family and domain databases
InterPro	IPR001969. Pept_Asp_AS. IPR009007. Pept_Aspartc_cat. IPR001461. Peptidase_A1. IPR012848. Propep_A1. [Graphical view]
Gene3D	G3DSA:2.40.70.10. Pept_Aspartc_cat. 1 hit.
PANTHER	PTHR13683. Peptidase_A1. 1 hit.
Pfam	PF07966. A1_Propeptide. 1 hit. PF00026. Asp. 1 hit. [Graphical view]
PRINTS	PR00792. PEPSIN.
PROSITE	PS00141. ASP_PROTEASE. 2 hits. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

RENI_CALJA

Accession

Primary (citable) accession number: Q9TSZ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	May 1, 2000
Last modified:	November 4, 2008
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)