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Protein

Renin

Gene

REN

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.By similarity

Catalytic activityi

Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.

Enzyme regulationi

Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei98 – 981PROSITE-ProRule annotation
Active sitei286 – 2861PROSITE-ProRule annotation

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. angiotensin maturation Source: Ensembl
  2. cell maturation Source: Ensembl
  3. drinking behavior Source: Ensembl
  4. hormone-mediated signaling pathway Source: Ensembl
  5. male gonad development Source: Ensembl
  6. mesonephros development Source: Ensembl
  7. regulation of MAPK cascade Source: Ensembl
  8. renin-angiotensin regulation of aldosterone production Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Renin (EC:3.4.23.15)
Alternative name(s):
Angiotensinogenase
Gene namesi
Name:REN
OrganismiCallithrix jacchus (White-tufted-ear marmoset)
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix
ProteomesiUP000008225: Chromosome 19

Subcellular locationi

Secreted By similarity. Membrane By similarity
Note: Associated to membranes via binding to ATP6AP2.By similarity

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. intracellular Source: Ensembl
  3. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Propeptidei24 – 6037Activation peptidePRO_0000026077Add
BLAST
Chaini61 – 400340ReninPRO_0000026078Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi111 ↔ 118By similarity
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi277 ↔ 281By similarity
Disulfide bondi319 ↔ 356By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Subunit structurei

Interacts with ATP6AP2.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9TSZ1.
SMRiQ9TSZ1. Positions 68-400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ9TSZ1.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TSZ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDAWRGMPRW GLLLLLWGSC TFGLPTETTT FKRISLKRMP SIRESLKERG
60 70 80 90 100
VDMARLGPER MALVNITSSV ILTNYMDTQY YGEIGIGTPP QTFKVVFDTG
110 120 130 140 150
SSNVWVPSSK CSRLYTACVY HKLFDASDSS SYKHNGTELT LRYSTGTVSG
160 170 180 190 200
FLSQDVITVG GITVTQTFGE VTEMPALPFM LAEFDGVVGM GFSEQAIGKV
210 220 230 240 250
TPLFDNIISQ GLLKEDVFSF YYNRDSENSQ SLGGQIVLGG SDPQHYEGNF
260 270 280 290 300
HYINLIRTGL WQIPMKGVSV GSSTLLCEDG CLALVDTGAS YISGSTSSIE
310 320 330 340 350
KLMEALGAKK RLFDYVVKCN EGPTLPDISF HLGGKEYTLT SADYVFQESY
360 370 380 390 400
SSKKLCTLAI HAMDIPPPTG PTWALGATFI RKFYTEFDRG NNRIGFALAR
Length:400
Mass (Da):44,038
Last modified:May 1, 2000 - v1
Checksum:i31769217035615FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132342 mRNA. Translation: CAB64879.1.
RefSeqiXP_008983729.1. XM_008985481.1.

Genome annotation databases

EnsembliENSCJAT00000032861; ENSCJAP00000031097; ENSCJAG00000016857.
GeneIDi100399036.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132342 mRNA. Translation: CAB64879.1.
RefSeqiXP_008983729.1. XM_008985481.1.

3D structure databases

ProteinModelPortaliQ9TSZ1.
SMRiQ9TSZ1. Positions 68-400.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

ChEMBLiCHEMBL6056.

Protein family/group databases

MEROPSiA01.007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCJAT00000032861; ENSCJAP00000031097; ENSCJAG00000016857.
GeneIDi100399036.

Phylogenomic databases

GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ9TSZ1.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of marmoset renin: comparison with human renin."
    Valdenaire O., Breu V., Giller T., Bur D., Fischli W.
    J. Cardiovasc. Pharmacol. 34:893-897(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiRENI_CALJA
AccessioniPrimary (citable) accession number: Q9TSZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 2000
Last modified: February 4, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.