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Protein

Renin

Gene

REN

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.By similarity

Catalytic activityi

Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.

Enzyme regulationi

Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei98PROSITE-ProRule annotation1
Active sitei286PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Renin (EC:3.4.23.15)
Alternative name(s):
Angiotensinogenase
Gene namesi
Name:REN
OrganismiCallithrix jacchus (White-tufted-ear marmoset)
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix
Proteomesi
  • UP000008225 Componenti: Chromosome 19

Subcellular locationi

  • Secreted By similarity
  • Membrane By similarity

  • Note: Associated to membranes via binding to ATP6AP2.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL6056.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
PropeptideiPRO_000002607724 – 60Activation peptideAdd BLAST37
ChainiPRO_000002607861 – 400ReninAdd BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi111 ↔ 118By similarity
Glycosylationi135N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi277 ↔ 281By similarity
Disulfide bondi319 ↔ 356By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Subunit structurei

Interacts with ATP6AP2.By similarity

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000046960.

Structurei

3D structure databases

ProteinModelPortaliQ9TSZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 397Peptidase A1PROSITE-ProRule annotationAdd BLAST318

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ9TSZ1.
KOiK01380.
OrthoDBiEOG091G0JP7.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TSZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAWRGMPRW GLLLLLWGSC TFGLPTETTT FKRISLKRMP SIRESLKERG
60 70 80 90 100
VDMARLGPER MALVNITSSV ILTNYMDTQY YGEIGIGTPP QTFKVVFDTG
110 120 130 140 150
SSNVWVPSSK CSRLYTACVY HKLFDASDSS SYKHNGTELT LRYSTGTVSG
160 170 180 190 200
FLSQDVITVG GITVTQTFGE VTEMPALPFM LAEFDGVVGM GFSEQAIGKV
210 220 230 240 250
TPLFDNIISQ GLLKEDVFSF YYNRDSENSQ SLGGQIVLGG SDPQHYEGNF
260 270 280 290 300
HYINLIRTGL WQIPMKGVSV GSSTLLCEDG CLALVDTGAS YISGSTSSIE
310 320 330 340 350
KLMEALGAKK RLFDYVVKCN EGPTLPDISF HLGGKEYTLT SADYVFQESY
360 370 380 390 400
SSKKLCTLAI HAMDIPPPTG PTWALGATFI RKFYTEFDRG NNRIGFALAR
Length:400
Mass (Da):44,038
Last modified:May 1, 2000 - v1
Checksum:i31769217035615FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132342 mRNA. Translation: CAB64879.1.
RefSeqiXP_008983729.1. XM_008985481.2.

Genome annotation databases

EnsembliENSCJAT00000032861; ENSCJAP00000031097; ENSCJAG00000016857.
GeneIDi100399036.
KEGGicjc:100399036.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132342 mRNA. Translation: CAB64879.1.
RefSeqiXP_008983729.1. XM_008985481.2.

3D structure databases

ProteinModelPortaliQ9TSZ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000046960.

Chemistry databases

ChEMBLiCHEMBL6056.

Protein family/group databases

MEROPSiA01.007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCJAT00000032861; ENSCJAP00000031097; ENSCJAG00000016857.
GeneIDi100399036.
KEGGicjc:100399036.

Organism-specific databases

CTDi5972.

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ9TSZ1.
KOiK01380.
OrthoDBiEOG091G0JP7.

Miscellaneous databases

PROiQ9TSZ1.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRENI_CALJA
AccessioniPrimary (citable) accession number: Q9TSZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.