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Q9TSZ1

- RENI_CALJA

UniProt

Q9TSZ1 - RENI_CALJA

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Protein
Renin
Gene
REN
Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney By similarity.

Catalytic activityi

Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.

Enzyme regulationi

Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei98 – 981 By similarity
Active sitei286 – 2861 By similarity

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. angiotensin maturation Source: Ensembl
  2. cell maturation Source: Ensembl
  3. drinking behavior Source: Ensembl
  4. hormone-mediated signaling pathway Source: Ensembl
  5. male gonad development Source: Ensembl
  6. mesonephros development Source: Ensembl
  7. regulation of MAPK cascade Source: Ensembl
  8. renin-angiotensin regulation of aldosterone production Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Renin (EC:3.4.23.15)
Alternative name(s):
Angiotensinogenase
Gene namesi
Name:REN
OrganismiCallithrix jacchus (White-tufted-ear marmoset)
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix
ProteomesiUP000008225: Chromosome 19

Subcellular locationi

Secreted By similarity. Membrane By similarity
Note: Associated to membranes via binding to ATP6AP2 By similarity.

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. intracellular Source: Ensembl
  3. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 By similarity
Add
BLAST
Propeptidei24 – 6037Activation peptide
PRO_0000026077Add
BLAST
Chaini61 – 400340Renin
PRO_0000026078Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi111 ↔ 118 By similarity
Glycosylationi135 – 1351N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi277 ↔ 281 By similarity
Disulfide bondi319 ↔ 356 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Subunit structurei

Interacts with ATP6AP2 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9TSZ1.
SMRiQ9TSZ1. Positions 68-400.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A1 family.

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00710000106265.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TSZ1-1 [UniParc]FASTAAdd to Basket

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MDAWRGMPRW GLLLLLWGSC TFGLPTETTT FKRISLKRMP SIRESLKERG    50
VDMARLGPER MALVNITSSV ILTNYMDTQY YGEIGIGTPP QTFKVVFDTG 100
SSNVWVPSSK CSRLYTACVY HKLFDASDSS SYKHNGTELT LRYSTGTVSG 150
FLSQDVITVG GITVTQTFGE VTEMPALPFM LAEFDGVVGM GFSEQAIGKV 200
TPLFDNIISQ GLLKEDVFSF YYNRDSENSQ SLGGQIVLGG SDPQHYEGNF 250
HYINLIRTGL WQIPMKGVSV GSSTLLCEDG CLALVDTGAS YISGSTSSIE 300
KLMEALGAKK RLFDYVVKCN EGPTLPDISF HLGGKEYTLT SADYVFQESY 350
SSKKLCTLAI HAMDIPPPTG PTWALGATFI RKFYTEFDRG NNRIGFALAR 400
Length:400
Mass (Da):44,038
Last modified:May 1, 2000 - v1
Checksum:i31769217035615FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ132342 mRNA. Translation: CAB64879.1.
RefSeqiXP_002760737.1. XM_002760691.1.

Genome annotation databases

EnsembliENSCJAT00000032861; ENSCJAP00000031097; ENSCJAG00000016857.
GeneIDi100399036.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ132342 mRNA. Translation: CAB64879.1 .
RefSeqi XP_002760737.1. XM_002760691.1.

3D structure databases

ProteinModelPortali Q9TSZ1.
SMRi Q9TSZ1. Positions 68-400.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL6056.

Protein family/group databases

MEROPSi A01.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCJAT00000032861 ; ENSCJAP00000031097 ; ENSCJAG00000016857 .
GeneIDi 100399036.

Organism-specific databases

CTDi 5972.

Phylogenomic databases

GeneTreei ENSGT00710000106265.
HOGENOMi HOG000197681.
HOVERGENi HBG000482.

Family and domain databases

Gene3Di 2.40.70.10. 2 hits.
InterProi IPR001461. Aspartic_peptidase.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR021109. Peptidase_aspartic_dom.
[Graphical view ]
PANTHERi PTHR13683. PTHR13683. 1 hit.
Pfami PF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view ]
PRINTSi PR00792. PEPSIN.
SUPFAMi SSF50630. SSF50630. 1 hit.
PROSITEi PS00141. ASP_PROTEASE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of marmoset renin: comparison with human renin."
    Valdenaire O., Breu V., Giller T., Bur D., Fischli W.
    J. Cardiovasc. Pharmacol. 34:893-897(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiRENI_CALJA
AccessioniPrimary (citable) accession number: Q9TSZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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