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Q9TSZ1

- RENI_CALJA

UniProt

Q9TSZ1 - RENI_CALJA

Protein

Renin

Gene

REN

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.By similarity

    Catalytic activityi

    Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.

    Enzyme regulationi

    Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei98 – 981PROSITE-ProRule annotation
    Active sitei286 – 2861PROSITE-ProRule annotation

    GO - Molecular functioni

    1. aspartic-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. angiotensin maturation Source: Ensembl
    2. cell maturation Source: Ensembl
    3. drinking behavior Source: Ensembl
    4. hormone-mediated signaling pathway Source: Ensembl
    5. male gonad development Source: Ensembl
    6. mesonephros development Source: Ensembl
    7. regulation of MAPK cascade Source: Ensembl
    8. renin-angiotensin regulation of aldosterone production Source: Ensembl

    Keywords - Molecular functioni

    Aspartyl protease, Hydrolase, Protease

    Protein family/group databases

    MEROPSiA01.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Renin (EC:3.4.23.15)
    Alternative name(s):
    Angiotensinogenase
    Gene namesi
    Name:REN
    OrganismiCallithrix jacchus (White-tufted-ear marmoset)
    Taxonomic identifieri9483 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix
    ProteomesiUP000008225: Chromosome 19

    Subcellular locationi

    Secreted By similarity. Membrane By similarity
    Note: Associated to membranes via binding to ATP6AP2.By similarity

    GO - Cellular componenti

    1. extracellular space Source: Ensembl
    2. intracellular Source: Ensembl
    3. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Propeptidei24 – 6037Activation peptidePRO_0000026077Add
    BLAST
    Chaini61 – 400340ReninPRO_0000026078Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi111 ↔ 118By similarity
    Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi277 ↔ 281By similarity
    Disulfide bondi319 ↔ 356By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Interactioni

    Subunit structurei

    Interacts with ATP6AP2.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9TSZ1.
    SMRiQ9TSZ1. Positions 68-400.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase A1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    GeneTreeiENSGT00710000106265.
    HOGENOMiHOG000197681.
    HOVERGENiHBG000482.

    Family and domain databases

    Gene3Di2.40.70.10. 2 hits.
    InterProiIPR001461. Aspartic_peptidase.
    IPR001969. Aspartic_peptidase_AS.
    IPR012848. Aspartic_peptidase_N.
    IPR021109. Peptidase_aspartic_dom.
    [Graphical view]
    PANTHERiPTHR13683. PTHR13683. 1 hit.
    PfamiPF07966. A1_Propeptide. 1 hit.
    PF00026. Asp. 1 hit.
    [Graphical view]
    PRINTSiPR00792. PEPSIN.
    SUPFAMiSSF50630. SSF50630. 1 hit.
    PROSITEiPS00141. ASP_PROTEASE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9TSZ1-1 [UniParc]FASTAAdd to Basket

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    MDAWRGMPRW GLLLLLWGSC TFGLPTETTT FKRISLKRMP SIRESLKERG    50
    VDMARLGPER MALVNITSSV ILTNYMDTQY YGEIGIGTPP QTFKVVFDTG 100
    SSNVWVPSSK CSRLYTACVY HKLFDASDSS SYKHNGTELT LRYSTGTVSG 150
    FLSQDVITVG GITVTQTFGE VTEMPALPFM LAEFDGVVGM GFSEQAIGKV 200
    TPLFDNIISQ GLLKEDVFSF YYNRDSENSQ SLGGQIVLGG SDPQHYEGNF 250
    HYINLIRTGL WQIPMKGVSV GSSTLLCEDG CLALVDTGAS YISGSTSSIE 300
    KLMEALGAKK RLFDYVVKCN EGPTLPDISF HLGGKEYTLT SADYVFQESY 350
    SSKKLCTLAI HAMDIPPPTG PTWALGATFI RKFYTEFDRG NNRIGFALAR 400
    Length:400
    Mass (Da):44,038
    Last modified:May 1, 2000 - v1
    Checksum:i31769217035615FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ132342 mRNA. Translation: CAB64879.1.
    RefSeqiXP_002760737.1. XM_002760691.1.

    Genome annotation databases

    EnsembliENSCJAT00000032861; ENSCJAP00000031097; ENSCJAG00000016857.
    GeneIDi100399036.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ132342 mRNA. Translation: CAB64879.1 .
    RefSeqi XP_002760737.1. XM_002760691.1.

    3D structure databases

    ProteinModelPortali Q9TSZ1.
    SMRi Q9TSZ1. Positions 68-400.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL6056.

    Protein family/group databases

    MEROPSi A01.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCJAT00000032861 ; ENSCJAP00000031097 ; ENSCJAG00000016857 .
    GeneIDi 100399036.

    Organism-specific databases

    CTDi 5972.

    Phylogenomic databases

    GeneTreei ENSGT00710000106265.
    HOGENOMi HOG000197681.
    HOVERGENi HBG000482.

    Family and domain databases

    Gene3Di 2.40.70.10. 2 hits.
    InterProi IPR001461. Aspartic_peptidase.
    IPR001969. Aspartic_peptidase_AS.
    IPR012848. Aspartic_peptidase_N.
    IPR021109. Peptidase_aspartic_dom.
    [Graphical view ]
    PANTHERi PTHR13683. PTHR13683. 1 hit.
    Pfami PF07966. A1_Propeptide. 1 hit.
    PF00026. Asp. 1 hit.
    [Graphical view ]
    PRINTSi PR00792. PEPSIN.
    SUPFAMi SSF50630. SSF50630. 1 hit.
    PROSITEi PS00141. ASP_PROTEASE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of marmoset renin: comparison with human renin."
      Valdenaire O., Breu V., Giller T., Bur D., Fischli W.
      J. Cardiovasc. Pharmacol. 34:893-897(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiRENI_CALJA
    AccessioniPrimary (citable) accession number: Q9TSZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3