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Protein

Beta-3 adrenergic receptor

Gene

ADRB3

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei117Agonist or antagonistBy similarity1
Binding sitei122Agonist or antagonistBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-3 adrenergic receptor
Alternative name(s):
Beta-3 adrenoreceptor
Short name:
Beta-3 adrenoceptor
Gene namesi
Name:ADRB3
Synonyms:BAR3
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Chromosome B1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37ExtracellularBy similarityAdd BLAST37
Transmembranei38 – 62Helical; Name=1By similarityAdd BLAST25
Topological domaini63 – 75CytoplasmicBy similarityAdd BLAST13
Transmembranei76 – 99Helical; Name=2By similarityAdd BLAST24
Topological domaini100 – 110ExtracellularBy similarityAdd BLAST11
Transmembranei111 – 133Helical; Name=3By similarityAdd BLAST23
Topological domaini134 – 154CytoplasmicBy similarityAdd BLAST21
Transmembranei155 – 178Helical; Name=4By similarityAdd BLAST24
Topological domaini179 – 201ExtracellularBy similarityAdd BLAST23
Transmembranei202 – 225Helical; Name=5By similarityAdd BLAST24
Topological domaini226 – 293CytoplasmicBy similarityAdd BLAST68
Transmembranei294 – 317Helical; Name=6By similarityAdd BLAST24
Topological domaini318 – 325ExtracellularBy similarity8
Transmembranei326 – 349Helical; Name=7By similarityAdd BLAST24
Topological domaini350 – 398CytoplasmicBy similarityAdd BLAST49

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691421 – 398Beta-3 adrenergic receptorAdd BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi110 ↔ 196PROSITE-ProRule annotation
Disulfide bondi189 ↔ 195PROSITE-ProRule annotation
Lipidationi361S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Interactioni

Subunit structurei

Interacts with ARRDC3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000009674.

Structurei

3D structure databases

ProteinModelPortaliQ9TST4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni198 – 212Agonist and antagonist bindingBy similarityAdd BLAST15
Regioni305 – 312Agonist and antagonist bindingBy similarity8
Regioni332 – 336Agonist and antagonist bindingBy similarity5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ9TST4.
KOiK04143.
OMAiAPIMSKW.
OrthoDBiEOG091G06VI.
TreeFamiTF316350.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000681. ADRB3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00563. ADRENRGCB3AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TST4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPWPHGNGS LASWPDAPTL TPNTANTSGL PGVPWAVALA GALLALAVLA
60 70 80 90 100
TVGGNLLVIV AIARTPRLQT MTNVFVTSLA TADLVVGLLV VPPGATLALT
110 120 130 140 150
GHWPLGATGC ELWTSVDVLC VTASIETLCA LAVDRYLAVT NPLRYGALVT
160 170 180 190 200
KRRARAAVVL VWVVSAAVSF APIMSKWWRV GADAEAQRCH SNPHCCAFAS
210 220 230 240 250
NIPYALLSSS VSFYLPLLVM LFVYARVFVV ATRQLRLLRG ELGRFPPGES
260 270 280 290 300
PPAASRSMSP APAGPCASPA GVPSYGRRPA RLLPLREHRA LRTLGLIMGT
310 320 330 340 350
FSLCWLPFFV ANVVRALGGP SLVPSPAFLA LNWLGYANSA FNPLIYCRSP
360 370 380 390
DFRSAFRRLL CRCRLEERHA AASGAGETSD APAALTRPAE SGLPGGIS
Length:398
Mass (Da):41,978
Last modified:May 1, 2000 - v1
Checksum:i069305C1A43ADE6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192488 Genomic DNA. Translation: AAF04592.1.
RefSeqiNP_001009336.1. NM_001009336.1.
XP_006930754.1. XM_006930692.2.
XP_006930755.1. XM_006930693.2.

Genome annotation databases

EnsembliENSFCAT00000010426; ENSFCAP00000009674; ENSFCAG00000010422.
GeneIDi493930.
KEGGifca:493930.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192488 Genomic DNA. Translation: AAF04592.1.
RefSeqiNP_001009336.1. NM_001009336.1.
XP_006930754.1. XM_006930692.2.
XP_006930755.1. XM_006930693.2.

3D structure databases

ProteinModelPortaliQ9TST4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000009674.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSFCAT00000010426; ENSFCAP00000009674; ENSFCAG00000010422.
GeneIDi493930.
KEGGifca:493930.

Organism-specific databases

CTDi155.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118774.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiQ9TST4.
KOiK04143.
OMAiAPIMSKW.
OrthoDBiEOG091G06VI.
TreeFamiTF316350.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000681. ADRB3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00563. ADRENRGCB3AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADRB3_FELCA
AccessioniPrimary (citable) accession number: Q9TST4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: October 5, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.