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Protein

Tumor necrosis factor receptor superfamily member 6

Gene

FAS

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 6
Alternative name(s):
Apo-1 antigen
Apoptosis-mediating surface antigen FAS
FASLG receptor
CD_antigen: CD95
Gene namesi
Name:FAS
Synonyms:APT1, TNFRSF6
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 171ExtracellularSequence analysisAdd BLAST146
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Topological domaini193 – 331CytoplasmicSequence analysisAdd BLAST139

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003456426 – 331Tumor necrosis factor receptor superfamily member 6Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 73PROSITE-ProRule annotation
Disulfide bondi63 ↔ 82PROSITE-ProRule annotation
Disulfide bondi85 ↔ 101PROSITE-ProRule annotation
Disulfide bondi104 ↔ 119PROSITE-ProRule annotation
Disulfide bondi107 ↔ 127PROSITE-ProRule annotation
Glycosylationi118N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi129 ↔ 143PROSITE-ProRule annotation
Disulfide bondi146 ↔ 157PROSITE-ProRule annotation
Disulfide bondi149 ↔ 165PROSITE-ProRule annotation
Modified residuei211PhosphothreonineBy similarity1
Modified residuei221PhosphoserineBy similarity1
Modified residuei318PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Interactioni

Subunit structurei

Binds DAXX and RIPK1. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Interacts with BRE and FEM1B (By similarity). Interacts with FADD (By similarity). Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9TSN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati47 – 83TNFR-Cys 1Add BLAST37
Repeati84 – 127TNFR-Cys 2Add BLAST44
Repeati128 – 166TNFR-Cys 3Add BLAST39
Domaini226 – 310DeathPROSITE-ProRule annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni209 – 313Interaction with HIPK3By similarityAdd BLAST105

Domaini

Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

Sequence similaritiesi

Contains 1 death domain.PROSITE-ProRule annotation
Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004091.
KOiK04390.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR008063. Fas_rcpt.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PANTHERiPTHR23097:SF114. PTHR23097:SF114. 1 hit.
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01680. TNFACTORR6.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TSN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGIWTLLPL VLTSVVRLLS KCVNAQVTDI SSKGFELRKI VTTIETQNLE
60 70 80 90 100
GLHHEGQFCR NPCPPGERKA RDCTVNEDEP DCVPCQEGKE YTDKGHFSSK
110 120 130 140 150
CRRCRLCDEG HGLEVEINCT RTQNTKCRCK PNFFCNSAVC EHCDPCTKCE
160 170 180 190 200
HGIIEECTLT SNTKCKEEDS RSDLPWLCLL LLLIPPIVYV VIKKACRKHR
210 220 230 240 250
KENQGPHEST TLNPETAINL SDVDLSKYIT TIAGAMTLSQ VKDFVRKNGV
260 270 280 290 300
SEAKIDEIKN DNVQDTAEQK VQLLRNWYQL HGKKDACDTL IKGLKTADLC
310 320 330
TLAEKIHAVI LKDITSDTEN SNFRNEIQSL V
Length:331
Mass (Da):37,266
Last modified:May 1, 2000 - v1
Checksum:i0C617508081B05DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031420 mRNA. Translation: BAA83551.1.
RefSeqiNP_001270444.1. NM_001283515.1.
UniGeneiMfa.5418.

Genome annotation databases

GeneIDi102140989.
KEGGimcf:102140989.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031420 mRNA. Translation: BAA83551.1.
RefSeqiNP_001270444.1. NM_001283515.1.
UniGeneiMfa.5418.

3D structure databases

ProteinModelPortaliQ9TSN4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102140989.
KEGGimcf:102140989.

Organism-specific databases

CTDi355.

Phylogenomic databases

HOVERGENiHBG004091.
KOiK04390.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR008063. Fas_rcpt.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PANTHERiPTHR23097:SF114. PTHR23097:SF114. 1 hit.
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01680. TNFACTORR6.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNR6_MACFA
AccessioniPrimary (citable) accession number: Q9TSN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 1, 2000
Last modified: October 5, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.