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Q9TSM6 (TP4A1_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein tyrosine phosphatase type IVA 1

EC=3.1.3.48
Alternative name(s):
Protein-tyrosine phosphatase 4a1
Protein-tyrosine phosphatase of regenerating liver 1
Short name=PRL-1
Gene names
Name:PTP4A1
Synonyms:PRL1
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length173 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Enzyme regulation

Inhibited by sodium orthovanadate and pentamidine By similarity.

Subunit structure

Homotrimer. Interacts with ATF5 and tubulin By similarity.

Subcellular location

Cell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasmcytoskeletonspindle. Note: And mitotic spindle. Ref.1

Tissue specificity

In the retina, expressed by red/green- but not blue-sensitive cone photoreceptor cells, and by rod bipolar cells (at protein level). Ref.1

Post-translational modification

Farnesylated. Farnesylation is required for membrane targeting By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 170170Protein tyrosine phosphatase type IVA 1
PRO_0000094781
Propeptide171 – 1733Removed in mature form By similarity
PRO_0000396727

Regions

Domain82 – 14867Tyrosine-protein phosphatase
Region97 – 13236Interaction with ATF5 By similarity
Region105 – 1106Phosphate binding By similarity

Sites

Active site721Proton donor By similarity
Active site1041Phosphocysteine intermediate By similarity
Binding site1101Substrate By similarity

Amino acid modifications

Modified residue1701Cysteine methyl ester By similarity
Lipidation1701S-farnesyl cysteine By similarity
Disulfide bond49 ↔ 104 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9TSM6 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 702008013D3F3835

FASTA17319,815
        10         20         30         40         50         60 
MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE ATYDTTLVEK 

        70         80         90        100        110        120 
EGIHVLDWPF DDGAPPSNQI VDDWLSLVKI KFREEPGCCI AVHCVAGLGR APVLVALALI 

       130        140        150        160        170 
EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE KYRPKMRLRF KDSNGHRNNC CIQ 

« Hide

References

[1]"Expression of the protein tyrosine phosphatase, phosphatase of regenerating liver 1, in the outer segments of primate cone photoreceptors."
Yarovinsky T.O., Rickman D.W., Diamond R.H., Taub R., Hageman G.S., Bowes Rickman C.
Brain Res. Mol. Brain Res. 77:95-103(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Retina.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF190930 mRNA. Translation: AAF05715.1.
RefSeqXP_005552682.1. XM_005552625.1.
XP_005552683.1. XM_005552626.1.
UniGeneMfa.5419.

3D structure databases

ProteinModelPortalQ9TSM6.
SMRQ9TSM6. Positions 9-160.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ9TSM6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID102134176.
KEGGmcf:102134176.

Organism-specific databases

CTD7803.

Phylogenomic databases

HOVERGENHBG071295.
KOK18041.

Family and domain databases

Gene3D3.90.190.10. 1 hit.
InterProIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00102. Y_phosphatase. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
PROSITEPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTP4A1_MACFA
AccessionPrimary (citable) accession number: Q9TSM6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families