Q9TSM6 (TP4A1_MACFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein tyrosine phosphatase type IVA 1
EC=3.1.3.48

Alternative name(s):
Protein-tyrosine phosphatase 4a1
Protein-tyrosine phosphatase of regenerating liver 1
Short name=PRL-1

Gene names

Name:	PTP4A1
Synonyms:	PRL1

Organism

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Cercopithecoidea › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	173 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Enzyme regulation	Inhibited by sodium orthovanadate and pentamidine By similarity.
Subunit structure	Homotrimer. Interacts with ATF5 and tubulin By similarity.
Subcellular location	Cell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm › cytoskeleton › spindle. Note: And mitotic spindle. Ref.1
Tissue specificity	In the retina, expressed by red/green- but not blue-sensitive cone photoreceptor cells, and by rod bipolar cells (at protein level). Ref.1
Post-translational modification	Farnesylated. Farnesylation is required for membrane targeting By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Biological process	Cell cycle
Cellular component	Cell membrane Cytoplasm Cytoskeleton Endoplasmic reticulum Endosome Membrane
Molecular function	Developmental protein Hydrolase Protein phosphatase
PTM	Disulfide bond Lipoprotein Methylation Prenylation
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	early endosome Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell spindle Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 170	170	Protein tyrosine phosphatase type IVA 1		PRO_0000094781
	Propeptide	171 – 173	3	Removed in mature form By similarity		PRO_0000396727
Regions
	Domain	82 – 148	67	Tyrosine-protein phosphatase
	Region	97 – 132	36	Interaction with ATF5 By similarity
	Region	105 – 110	6	Phosphate binding By similarity
Sites
	Active site	72	1	Proton donor By similarity
	Active site	104	1	Phosphocysteine intermediate By similarity
	Binding site	110	1	Substrate By similarity
Amino acid modifications
	Modified residue	170	1	Cysteine methyl ester By similarity
	Lipidation	170	1	S-farnesyl cysteine By similarity
	Disulfide bond	49 ↔ 104		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9TSM6 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 702008013D3F3835	FASTA	173	19,815
	10 20 30 40 50 60 MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE ATYDTTLVEK 70 80 90 100 110 120 EGIHVLDWPF DDGAPPSNQI VDDWLSLVKI KFREEPGCCI AVHCVAGLGR APVLVALALI 130 140 150 160 170 EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE KYRPKMRLRF KDSNGHRNNC CIQ

References

[1]

"Expression of the protein tyrosine phosphatase, phosphatase of regenerating liver 1, in the outer segments of primate cone photoreceptors." Yarovinsky T.O., Rickman D.W., Diamond R.H., Taub R., Hageman G.S., Bowes Rickman C. Brain Res. Mol. Brain Res. 77:95-103(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Retina.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF190930 mRNA. Translation: AAF05715.1.
3D structure databases
ProteinModelPortal	Q9TSM6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG071295.
Family and domain databases
InterPro	IPR000387. Tyr/Dual-sp_Pase. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Pfam	PF00102. Y_phosphatase. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. False negative. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. False negative. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9TSM6.

Entry information

Entry name

TP4A1_MACFA

Accession

Primary (citable) accession number: Q9TSM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program