Q9TSM4 (GSTM2_MACFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione S-transferase Mu 2
EC=2.5.1.18

Alternative name(s):
GST class-mu 2
GSTM2-2

Gene names

Name:

GSTM2

Organism

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Cercopithecoidea › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has activity toward aflatoxin B(1)-8,9-epoxide (AFBO).
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the GST superfamily. Mu family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Transferase
Gene Ontology (GO)
Biological_process	glutathione metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutathione transferase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 218	217	Glutathione S-transferase Mu 2		PRO_0000185819
Regions
	Domain	2 – 88	87	GST N-terminal
	Domain	90 – 208	119	GST C-terminal
	Region	7 – 8	2	Glutathione binding By similarity
	Region	46 – 50	5	Glutathione binding By similarity
	Region	59 – 60	2	Glutathione binding By similarity
	Region	72 – 73	2	Glutathione binding By similarity
Sites
	Binding site	116	1	Substrate By similarity
	Site	210	1	Important for substrate specificity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9TSM4 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: F2E509C3949F9051	FASTA	218	25,709
	10 20 30 40 50 60 MPMTLGYWNI RGLAHSIRLL LEYTGSSYEE KKYTMGDAPD YDRSQWLNEK FKLGLDFPNL 70 80 90 100 110 120 PYLIDGTHKI TQSNAILRYI ARKHNLCGET EKEKIREDIL ENQLMDNRMQ LARLCYDPDF 130 140 150 160 170 180 EKLKPEYLEG LPEMLKLYSQ FLGKQPWFLG DKITFVDFIA YDVLERNQVF EPSCLDAFPN 190 200 210 LKDFISRFEG LEKISAYMKS SRFLPRPVFT KMAVWGNK

References

[1]

"Mu-class GSTs are responsible for aflatoxin B(1)-8,9-epoxide-conjugating activity in the nonhuman primate Macaca fascicularis liver." Wang C., Bammler T.K., Guo Y., Kelly E.J., Eaton D.L. Toxicol. Sci. 56:26-36(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF200710 mRNA. Translation: AAF08540.1.
3D structure databases
ProteinModelPortal	Q9TSM4.
SMR	Q9TSM4. Positions 2-218.
ModBase	Search...
Proteomic databases
PRIDE	Q9TSM4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG106842.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR003081. GST_mu. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PRINTS	PR01267. GSTRNSFRASEM.
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTM2_MACFA

Accession

Primary (citable) accession number: Q9TSM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 56 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program