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Q9TSL6

- UDB23_MACFA

UniProt

Q9TSL6 - UDB23_MACFA

Protein

UDP-glucuronosyltransferase 2B23

Gene

UGT2B23

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on 6 steroids and the bile acid, hyodeoxycholic acid. May potentially play an important role in estrogen and androgen catabolism in peripheral steroid target tissues.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    Kineticsi

    1. KM=0.9 µM for androsterone
    2. KM=13.5 µM for 3-alpha-diol
    3. KM=1.6 µM for estriol
    4. KM=5.7 µM for 4-hydroxyestrone

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2B23 (EC:2.4.1.17)
    Short name:
    UDPGT 2B23
    Gene namesi
    Name:UGT2B23
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 529505UDP-glucuronosyltransferase 2B23PRO_0000036045Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    Expressed in several tissues, including the prostate, mammary gland, epididymis, testis and ovary.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9TSL6.
    SMRiQ9TSL6. Positions 285-446.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei494 – 51421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004033.
    KOiK00699.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9TSL6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVKWTSVIL LIQLSFYFSS GSCGKVLVWA AEYSHWMNMK TILEELVQRG    50
    HEVTALASSA SILFDPNNSS ALKIEVFPTS LPKPEFENIV TQEIKRWIEL 100
    PKDTFWLYFS QMQEIMWKFG DIFRNFCKDV VSNKKLMKKL QESRFDVVFA 150
    DPIFPCSELL AELFNIPLVY SLRFTPGYVF EKHCGGFLFP PSYVPVVMSE 200
    LSDQMTFMER VKNMIYMLYF DFCFQIYDMK KWDQFYTEVL GRHTTLSEIM 250
    GKADIWLIRN SWNFQFPHPL LPNVDFIGGL LCKPAKPLPK EMEEFVQSSG 300
    ENGVVVFTLG SMITNMKEER ANVIASALAQ IPQKVLWRFD GNKPDTLGVN 350
    TRLYKWIPQN DLLGHPKTKA FITHGGANGI YEAIYHGVPM VGIPLFADQP 400
    DNIAHMKTRG AAVQLDFDTM SSTDLVNALK TVINDPLYKE NVMKLSRIQR 450
    DQPVKPLDRA VFWIEFVMRH KGAKHLRPAA HDLTWFQYHS FDVIGFLLAC 500
    VATVIFIIMK CCLFCFWKFA RKGKKGKSD 529
    Length:529
    Mass (Da):60,957
    Last modified:May 1, 2000 - v1
    Checksum:i646315E6D970541A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF112113 mRNA. Translation: AAF14353.1.
    RefSeqiNP_001271768.1. NM_001284839.1.
    UniGeneiMfa.8183.

    Genome annotation databases

    GeneIDi102125239.
    KEGGimcf:102125239.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF112113 mRNA. Translation: AAF14353.1 .
    RefSeqi NP_001271768.1. NM_001284839.1.
    UniGenei Mfa.8183.

    3D structure databases

    ProteinModelPortali Q9TSL6.
    SMRi Q9TSL6. Positions 285-446.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 102125239.
    KEGGi mcf:102125239.

    Organism-specific databases

    CTDi 102125239.

    Phylogenomic databases

    HOVERGENi HBG004033.
    KOi K00699.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "UGT2B23, a novel uridine diphosphate-glucuronosyltransferase enzyme expressed in steroid target tissues that conjugates androgen and estrogen metabolites."
      Barbier O., Levesque E., Belanger A., Hum D.W.
      Endocrinology 140:5538-5548(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiUDB23_MACFA
    AccessioniPrimary (citable) accession number: Q9TSL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3