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Protein

UDP-glucuronosyltransferase 2B23

Gene

UGT2B23

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on 6 steroids and the bile acid, hyodeoxycholic acid. May potentially play an important role in estrogen and androgen catabolism in peripheral steroid target tissues.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Kineticsi

  1. KM=0.9 µM for androsterone
  2. KM=13.5 µM for 3-alpha-diol
  3. KM=1.6 µM for estriol
  4. KM=5.7 µM for 4-hydroxyestrone

    GO - Molecular functioni

    Complete GO annotation...

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2B23 (EC:2.4.1.17)
    Short name:
    UDPGT 2B23
    Gene namesi
    Name:UGT2B23
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei494 – 51421HelicalSequence AnalysisAdd
    BLAST

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 529505UDP-glucuronosyltransferase 2B23PRO_0000036045Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    Expressed in several tissues, including the prostate, mammary gland, epididymis, testis and ovary.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9TSL6.
    SMRiQ9TSL6. Positions 285-446.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004033.
    KOiK00699.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9TSL6-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MSVKWTSVIL LIQLSFYFSS GSCGKVLVWA AEYSHWMNMK TILEELVQRG
    60 70 80 90 100
    HEVTALASSA SILFDPNNSS ALKIEVFPTS LPKPEFENIV TQEIKRWIEL
    110 120 130 140 150
    PKDTFWLYFS QMQEIMWKFG DIFRNFCKDV VSNKKLMKKL QESRFDVVFA
    160 170 180 190 200
    DPIFPCSELL AELFNIPLVY SLRFTPGYVF EKHCGGFLFP PSYVPVVMSE
    210 220 230 240 250
    LSDQMTFMER VKNMIYMLYF DFCFQIYDMK KWDQFYTEVL GRHTTLSEIM
    260 270 280 290 300
    GKADIWLIRN SWNFQFPHPL LPNVDFIGGL LCKPAKPLPK EMEEFVQSSG
    310 320 330 340 350
    ENGVVVFTLG SMITNMKEER ANVIASALAQ IPQKVLWRFD GNKPDTLGVN
    360 370 380 390 400
    TRLYKWIPQN DLLGHPKTKA FITHGGANGI YEAIYHGVPM VGIPLFADQP
    410 420 430 440 450
    DNIAHMKTRG AAVQLDFDTM SSTDLVNALK TVINDPLYKE NVMKLSRIQR
    460 470 480 490 500
    DQPVKPLDRA VFWIEFVMRH KGAKHLRPAA HDLTWFQYHS FDVIGFLLAC
    510 520
    VATVIFIIMK CCLFCFWKFA RKGKKGKSD
    Length:529
    Mass (Da):60,957
    Last modified:May 1, 2000 - v1
    Checksum:i646315E6D970541A
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF112113 mRNA. Translation: AAF14353.1.
    RefSeqiNP_001271768.1. NM_001284839.1.
    UniGeneiMfa.8183.

    Genome annotation databases

    GeneIDi102125239.
    KEGGimcf:102125239.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF112113 mRNA. Translation: AAF14353.1.
    RefSeqiNP_001271768.1. NM_001284839.1.
    UniGeneiMfa.8183.

    3D structure databases

    ProteinModelPortaliQ9TSL6.
    SMRiQ9TSL6. Positions 285-446.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    GeneIDi102125239.
    KEGGimcf:102125239.

    Organism-specific databases

    CTDi102125239.

    Phylogenomic databases

    HOVERGENiHBG004033.
    KOiK00699.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Publicationsi

    1. "UGT2B23, a novel uridine diphosphate-glucuronosyltransferase enzyme expressed in steroid target tissues that conjugates androgen and estrogen metabolites."
      Barbier O., Levesque E., Belanger A., Hum D.W.
      Endocrinology 140:5538-5548(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiUDB23_MACFA
    AccessioniPrimary (citable) accession number: Q9TSL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: May 1, 2000
    Last modified: January 7, 2015
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.