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Reviewed, UniProtKB/Swiss-Prot Q9TSL6 (UDB23_MACFA)

Last modified June 16, 2009. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    UDP-glucuronosyltransferase 2B23
      Short name=UDPGT 2B23
    EC=2.4.1.17
Gene names
Name: UGT2B23
OrganismMacaca fascicularis (Crab eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

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Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on 6 steroids and the bile acid, hyodeoxycholic acid. May potentially play an important role in estrogen and androgen catabolism in peripheral steroid target tissues.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Tissue specificity

Expressed in several tissues, including the prostate, mammary gland, epididymis, testis and ovary. Ref.1

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Biophysicochemical properties

Kinetic parameters:

KM=0.9 µM for androsterone

KM=13.5 µM for 3-alpha-diol

KM=1.6 µM for estriol

KM=5.7 µM for 4-hydroxyestrone

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Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   DomainSignal
Transmembrane
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processmetabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

microsome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglucuronosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 529505UDP-glucuronosyltransferase 2B23
PRO_0000036045

Regions

Transmembrane494 – 51421 Potential

Amino acid modifications

Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation681N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q9TSL6-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 646315E6D970541A

FASTA52960,957
        10         20         30         40         50         60 
MSVKWTSVIL LIQLSFYFSS GSCGKVLVWA AEYSHWMNMK TILEELVQRG HEVTALASSA 

        70         80         90        100        110        120 
SILFDPNNSS ALKIEVFPTS LPKPEFENIV TQEIKRWIEL PKDTFWLYFS QMQEIMWKFG 

       130        140        150        160        170        180 
DIFRNFCKDV VSNKKLMKKL QESRFDVVFA DPIFPCSELL AELFNIPLVY SLRFTPGYVF 

       190        200        210        220        230        240 
EKHCGGFLFP PSYVPVVMSE LSDQMTFMER VKNMIYMLYF DFCFQIYDMK KWDQFYTEVL 

       250        260        270        280        290        300 
GRHTTLSEIM GKADIWLIRN SWNFQFPHPL LPNVDFIGGL LCKPAKPLPK EMEEFVQSSG 

       310        320        330        340        350        360 
ENGVVVFTLG SMITNMKEER ANVIASALAQ IPQKVLWRFD GNKPDTLGVN TRLYKWIPQN 

       370        380        390        400        410        420 
DLLGHPKTKA FITHGGANGI YEAIYHGVPM VGIPLFADQP DNIAHMKTRG AAVQLDFDTM 

       430        440        450        460        470        480 
SSTDLVNALK TVINDPLYKE NVMKLSRIQR DQPVKPLDRA VFWIEFVMRH KGAKHLRPAA 

       490        500        510        520 
HDLTWFQYHS FDVIGFLLAC VATVIFIIMK CCLFCFWKFA RKGKKGKSD

« Hide

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References

[1]"UGT2B23, a novel uridine diphosphate-glucuronosyltransferase enzyme expressed in steroid target tissues that conjugates androgen and estrogen metabolites."
Barbier O., Levesque E., Belanger A., Hum D.W.
Endocrinology 140:5538-5548(1999) [PubMed: 10579317] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.

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Cross-references

Sequence databases

AF112113 mRNA. Translation: AAF14353.1.

3D structure databases

SMRQ9TSL6. Positions 285-446.
ModBaseSearch...

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Phylogenomic databases

HOVERGENQ9TSL6.

Enzyme and pathway databases

BRENDA2.4.1.17. 3438.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. UDP_glucos_trans. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameUDB23_MACFA
AccessionPrimary (citable) accession number: Q9TSL6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 1, 2000
Last modified: June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents