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Q9TRZ7

- TIMP2_RABIT

UniProt

Q9TRZ7 - TIMP2_RABIT

Protein

Metalloproteinase inhibitor 2

Gene

TIMP2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi1 – 11Zinc; via amino nitrogen and carbonyl oxygen; shared with metalloproteinase partnerBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiI35.002.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metalloproteinase inhibitor 2
    Alternative name(s):
    Tissue inhibitor of metalloproteinases 2
    Short name:
    TIMP-2
    Gene namesi
    Name:TIMP2
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 194194Metalloproteinase inhibitor 2PRO_0000220984Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi1 ↔ 72PROSITE-ProRule annotation
    Disulfide bondi3 ↔ 101PROSITE-ProRule annotation
    Disulfide bondi13 ↔ 126PROSITE-ProRule annotation
    Disulfide bondi128 ↔ 175PROSITE-ProRule annotation
    Disulfide bondi133 ↔ 138PROSITE-ProRule annotation
    Disulfide bondi146 ↔ 167PROSITE-ProRule annotation

    Post-translational modificationi

    The activity of TIMP2 is dependent on the presence of disulfide bonds.By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9TRZ7.
    SMRiQ9TRZ7. Positions 1-192.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 126126NTRPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 55Involved in metalloproteinase-bindingBy similarity
    Regioni69 – 702Involved in metalloproteinase-bindingBy similarity

    Sequence similaritiesi

    Contains 1 NTR domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG243625.
    HOGENOMiHOG000285981.
    HOVERGENiHBG068749.

    Family and domain databases

    Gene3Di3.90.370.10. 1 hit.
    InterProiIPR001134. Netrin_domain.
    IPR001820. Prot_inh_TIMP.
    IPR008993. TIMP-like_OB-fold.
    IPR015613. TIMP2.
    IPR027465. TIMP_C_dom.
    [Graphical view]
    PANTHERiPTHR11844. PTHR11844. 1 hit.
    PTHR11844:SF7. PTHR11844:SF7. 1 hit.
    PfamiPF00965. TIMP. 1 hit.
    [Graphical view]
    SMARTiSM00206. NTR. 1 hit.
    [Graphical view]
    SUPFAMiSSF50242. SSF50242. 1 hit.
    PROSITEiPS50189. NTR. 1 hit.
    PS00288. TIMP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9TRZ7-1 [UniParc]FASTAAdd to Basket

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    CSCSPVHPQQ AFCNADIVIR AKAVNKKEVD SGNDIYGNPI KRIQYEIKQI    50
    KMFKGPDQDI EFIYTAPSSA VCGVSLDIGG KKEYLIAGKA EGNGNMHITL 100
    CDFIVPWDTL SATQKKSLNH RYQMGCECKI TRCPMIPCYI SSPDECLWMD 150
    WVTEKNINRH QAKFFACIKR SDGSCAWYRG AAPPKQEFLD IEDP 194
    Length:194
    Mass (Da):21,849
    Last modified:May 1, 2000 - v1
    Checksum:iCDC8101A2D38C4A9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti17 – 171I → V in AAC95005. (PubMed:9837780)Curated
    Sequence conflicti25 – 262NK → SE in AAC95005. (PubMed:9837780)Curated
    Sequence conflicti58 – 581Q → K in AAC95005. (PubMed:9837780)Curated
    Sequence conflicti78 – 781I → V in AAC95005. (PubMed:9837780)Curated
    Sequence conflicti93 – 953NGN → DGR in AAC95005. (PubMed:9837780)Curated
    Sequence conflicti109 – 1091T → S in AAC95005. (PubMed:9837780)Curated
    Sequence conflicti112 – 1121A → S in AAC95005. (PubMed:9837780)Curated
    Sequence conflicti131 – 1311T → S in AAC95005. (PubMed:9837780)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF069713 mRNA. Translation: AAC95005.1.
    UniGeneiOcu.2314.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF069713 mRNA. Translation: AAC95005.1 .
    UniGenei Ocu.2314.

    3D structure databases

    ProteinModelPortali Q9TRZ7.
    SMRi Q9TRZ7. Positions 1-192.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I35.002.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG243625.
    HOGENOMi HOG000285981.
    HOVERGENi HBG068749.

    Family and domain databases

    Gene3Di 3.90.370.10. 1 hit.
    InterProi IPR001134. Netrin_domain.
    IPR001820. Prot_inh_TIMP.
    IPR008993. TIMP-like_OB-fold.
    IPR015613. TIMP2.
    IPR027465. TIMP_C_dom.
    [Graphical view ]
    PANTHERi PTHR11844. PTHR11844. 1 hit.
    PTHR11844:SF7. PTHR11844:SF7. 1 hit.
    Pfami PF00965. TIMP. 1 hit.
    [Graphical view ]
    SMARTi SM00206. NTR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50242. SSF50242. 1 hit.
    PROSITEi PS50189. NTR. 1 hit.
    PS00288. TIMP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of rabbit TIMP2."
      Wertheimer S.J., Katz S.L.
      Inflamm. Res. 44:S121-S122(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Temporal alterations in mRNA levels for proteinases and inhibitors and their potential regulators in the healing medial collateral ligament."
      Reno C., Boykiw R., Martinez M.L., Hart D.A.
      Biochem. Biophys. Res. Commun. 252:757-763(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-154.
      Strain: New Zealand white.

    Entry informationi

    Entry nameiTIMP2_RABIT
    AccessioniPrimary (citable) accession number: Q9TRZ7
    Secondary accession number(s): O97589
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3