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Q9TRY9

- BGAL_CANFA

UniProt

Q9TRY9 - BGAL_CANFA

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Protein

Beta-galactosidase

Gene
GLB1
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei189 – 1891Proton donor Reviewed prediction
Active sitei269 – 2691Nucleophile Reviewed prediction

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiREACT_182226. Glycosphingolipid metabolism.
REACT_182384. Keratan sulfate degradation.
REACT_220733. HS-GAG degradation.
REACT_222277. Sialic acid metabolism.

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Alternative name(s):
Acid beta-galactosidase
Short name:
Lactase
Gene namesi
Name:GLB1
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Propeptidei25 – 295 By similarityPRO_0000012181
Chaini30 – 668639Beta-galactosidasePRO_0000012182Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi248 – 2481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi465 – 4651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi499 – 4991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi546 – 5461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi556 – 5561N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9TRY9.
PRIDEiQ9TRY9.

Structurei

3D structure databases

ProteinModelPortaliQ9TRY9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1874.
HOGENOMiHOG000221607.
HOVERGENiHBG004841.
InParanoidiQ9TRY9.
KOiK12309.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR026283. B-gal_1-like.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PIRSFiPIRSF006336. B-gal. 1 hit.
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TRY9-1 [UniParc]FASTAAdd to Basket

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MARPAAVRVL WALLLPLLLG SARGLRNASQ RTFTIDYSHN RFLKDGQPFR    50
YISGSIHYSR VPRFYWKDRL LKMKMAGLNA IQTYVPWNFH EPQPGQYQFS 100
GEQDVEYFIK LAHELGLLVI LRPGPYICAE WDMGGLPAWL LLKESIILRS 150
SDPDYLAAVD KWLGVLLPKM KPLLYQNGGP IITMQVENEY GSYFTCDYDY 200
LRFLQKLFHH HLGNDVLLFT TDGANEKFLQ CGALQGLYAT VDFGPGANIT 250
AAFQIQRKSE PKGPLVNSEF YTGWLDHWGQ PHSTVRTEVV ASSLHDILAH 300
GANVNLYMFI GGTNFAYWNG ANMPYQAQPT SYDYDAPLSE AGDLTEKYFA 350
LREVIRKFEK VPEGFIPPST PKFAYGKVAL KKLKTVEEAL NVLCPPGPIN 400
SLYPLTFIQV KQYFGFVMYR TTLPQDCSDP TPLSSPLSGV HDRAYVSVDG 450
VPQGVMERSN VITLNITGKA GATLDLLVEN MGRVNYGRYI NDFKGLISNL 500
TLGSSILTNW MIFPLNTEDA VRSHLGGWHG PNNGRHDKTF AHRSSNYTLP 550
AFYMGNFSIP SGIPDLPQDT FIQFPGWTKG QVWINGFNLG RYWPARGPQM 600
TLFVPRHILV TSTPNTIMVL ELEHAPCGDS GPEVCTVEFV DRPVIGAPPT 650
PGHPPPDLSH RDLRLDYV 668
Length:668
Mass (Da):74,992
Last modified:May 2, 2006 - v3
Checksum:i56B4A4AC7357221E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti280 – 2801Q → P.
Natural varianti442 – 4421D → V.
Natural varianti444 – 4441A → V.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601R → H1 Publication
Sequence conflicti227 – 2271K → L1 Publication
Sequence conflicti342 – 3421G → A1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ196436 mRNA. Translation: ABA43388.1.
AF056084 mRNA. Translation: AAC12775.1.
RefSeqiNP_001032730.1. NM_001037641.1.
UniGeneiCfa.22721.

Genome annotation databases

GeneIDi403873.
KEGGicfa:403873.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ196436 mRNA. Translation: ABA43388.1 .
AF056084 mRNA. Translation: AAC12775.1 .
RefSeqi NP_001032730.1. NM_001037641.1.
UniGenei Cfa.22721.

3D structure databases

ProteinModelPortali Q9TRY9.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH35. Glycoside Hydrolase Family 35.

Proteomic databases

PaxDbi Q9TRY9.
PRIDEi Q9TRY9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403873.
KEGGi cfa:403873.

Organism-specific databases

CTDi 2720.

Phylogenomic databases

eggNOGi COG1874.
HOGENOMi HOG000221607.
HOVERGENi HBG004841.
InParanoidi Q9TRY9.
KOi K12309.

Enzyme and pathway databases

Reactomei REACT_182226. Glycosphingolipid metabolism.
REACT_182384. Keratan sulfate degradation.
REACT_220733. HS-GAG degradation.
REACT_222277. Sialic acid metabolism.

Miscellaneous databases

NextBioi 20817366.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR026283. B-gal_1-like.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PIRSFi PIRSF006336. B-gal. 1 hit.
PRINTSi PR00742. GLHYDRLASE35.
SUPFAMi SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEi PS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The entire coding region of the canine lysosomal beta-galactosidase (GLB1) gene."
    Kreutzer R., Mueller G., Leeb T., Moritz A., Baumgaertner W.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skin.
  2. "A partial sequence of canine lysosomal beta-galactosidase (GLB1)."
    Smith B.F., Georgeson M., Baker H.J.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-668.
    Strain: Beagle.
    Tissue: Brain.
  3. "Comparison of the canine and human acid beta-galactosidase gene."
    Ahern-Rindell A.J., Kretz K.A., O'Brien J.S.
    Am. J. Med. Genet. 63:340-345(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 27-668.
    Tissue: Kidney, Muscle, Pancreas and Testis.

Entry informationi

Entry nameiBGAL_CANFA
AccessioniPrimary (citable) accession number: Q9TRY9
Secondary accession number(s): O62800, Q3HTI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: May 2, 2006
Last modified: September 3, 2014
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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