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Q9TRY0

- FKBP4_BOVIN

UniProt

Q9TRY0 - FKBP4_BOVIN

Protein

Peptidyl-prolyl cis-trans isomerase FKBP4

Gene

FKBP4

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Immunophilin protein with PPIase and co-chaperone activities By similarity. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90) By similarity. May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments By similarity. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening By similarity. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria By similarity.By similarity

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    Enzyme regulationi

    Inhibited by FK506.By similarity

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB
    2. protein binding Source: IntAct

    GO - Biological processi

    1. chaperone-mediated protein folding Source: UniProtKB
    2. negative regulation of microtubule polymerization or depolymerization Source: UniProtKB
    3. negative regulation of neuron projection development Source: UniProtKB
    4. protein peptidyl-prolyl isomerization Source: GOC

    Keywords - Molecular functioni

    Chaperone, Isomerase, Rotamase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP4 (EC:5.2.1.8)
    Short name:
    PPIase FKBP4
    Alternative name(s):
    52 kDa FK506-binding protein
    Short name:
    52 kDa FKBP
    Short name:
    FKBP-52
    FK506-binding protein 4
    Short name:
    FKBP-4
    HSP-binding immunophilin
    Short name:
    HBI
    Immunophilin FKBP52
    Rotamase
    Cleaved into the following chain:
    Gene namesi
    Name:FKBP4
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Cytoplasmcytosol By similarity. Mitochondrion By similarity. Nucleus By similarity. Cytoplasmcytoskeleton By similarity
    Note: Shuttles from mitochondria to nucleus; colocalizes in mitochondria with the glucocorticoid receptor.By similarity

    GO - Cellular componenti

    1. axonal growth cone Source: UniProtKB
    2. cytosol Source: UniProtKB
    3. microtubule Source: UniProtKB-KW
    4. mitochondrion Source: UniProtKB-SubCell
    5. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule, Mitochondrion, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 459459Peptidyl-prolyl cis-trans isomerase FKBP4PRO_0000391467Add
    BLAST
    Initiator methioninei1 – 11Removed; alternateBy similarity
    Chaini2 – 459458Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processedPRO_0000075317Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine; in peptidyl-prolyl cis-trans isomerase FKBP4; alternateBy similarity
    Modified residuei2 – 21N-acetylthreonine; in peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; partialBy similarity
    Modified residuei143 – 1431PhosphothreonineBy similarity
    Modified residuei282 – 2821N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ9TRY0.
    PRIDEiQ9TRY0.

    Interactioni

    Subunit structurei

    Homodimer By similarity. Associates with HSP90 and HSP70 in unactivated steroid hormone receptor complexes. Also interacts with peroxisomal phytanoyl-CoA alpha-hydroxylase (PHYH). Interacts with NR3C1 and dynein By similarity. Interacts with HSF1 in the HSP90 complex By similarity. Associates with tubulin By similarity. Interacts with MAPT/TAU By similarity. Interacts (via TPR domain) with S100A1, S100A2 and S100A6; the interaction is Ca2+ dependent By similarity. Interaction with S100A1 and S100A2 (but not with S100A6) leads to inhibition of FKBP4-HSP90 interaction By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    S100A1P026392EBI-6477371,EBI-6477285

    Protein-protein interaction databases

    IntActiQ9TRY0. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9TRY0.
    SMRiQ9TRY0. Positions 16-425.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini50 – 13889PPIase FKBP-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini167 – 25387PPIase FKBP-type 2PROSITE-ProRule annotationAdd
    BLAST
    Repeati270 – 30334TPR 1Add
    BLAST
    Repeati319 – 35234TPR 2Add
    BLAST
    Repeati354 – 38633TPR 3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni267 – 400134Interaction with tubulinBy similarityAdd
    BLAST

    Domaini

    The PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA).By similarity
    The C-terminal region (AA 375-458) is required to prevent tubulin polymerization.By similarity
    The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400.By similarity
    The TPR repeats mediate mitochondrial localization.By similarity

    Sequence similaritiesi

    Contains 2 PPIase FKBP-type domains.PROSITE-ProRule annotation
    Contains 3 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0545.
    HOGENOMiHOG000256916.
    HOVERGENiHBG051624.
    InParanoidiQ9TRY0.
    KOiK09571.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00254. FKBP_C. 2 hits.
    PF00515. TPR_1. 1 hit.
    [Graphical view]
    SMARTiSM00028. TPR. 3 hits.
    [Graphical view]
    PROSITEiPS50059. FKBP_PPIASE. 2 hits.
    PS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9TRY0-1 [UniParc]FASTAAdd to Basket

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    MTAEETKAAE SGAQSAPLRL EGVDISPKQD EGVLKVIKRE GTGTETPMIG    50
    DRVFVHYTGW LLDGTKFDSS LDRKDRFSFD LGKGEVIKAW DIAVATMKVG 100
    EVCHITCKPE YAYGLAGSPP KIPPNATLVF EVELFEFKGE DLTEEEDGGI 150
    IRRIRTRGEG YAKPNEGALV EVALEGYFKD QVFDRRELRF EVGEGESMDL 200
    PCGLEKAIQR MEKGEHSIVY LKPRYAFGSA GKEKFQIPPN AELKYEIHLK 250
    SFEKAKESWE MSSEEKLEQS TIVKERGTVY FKEGKYKQAV LQYKKIVSWL 300
    EYESSFSDED AEKAQALRLA SHLNLAMCHL KLQAFSAAIE NCNKALELDS 350
    NNEKGLFRRG EAHLAVNDFD LARADFQKVL QLYPSNKAAK AQLVVCQQRI 400
    RKQLEKEKKL YANMFERLAE EETKAKATVA AGDQPADAEM RDEPKNDVAG 450
    GQPQVEAEA 459
    Length:459
    Mass (Da):51,529
    Last modified:January 23, 2007 - v4
    Checksum:i2A0A25B737BC9A7B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti428 – 4281T → L AA sequence (PubMed:1279700)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT030531 mRNA. Translation: ABQ12971.1.
    BC102456 mRNA. Translation: AAI02457.1.
    PIRiA42576.
    B42576.
    RefSeqiNP_001029494.1. NM_001034322.2.
    UniGeneiBt.4797.

    Genome annotation databases

    GeneIDi508535.
    KEGGibta:508535.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT030531 mRNA. Translation: ABQ12971.1 .
    BC102456 mRNA. Translation: AAI02457.1 .
    PIRi A42576.
    B42576.
    RefSeqi NP_001029494.1. NM_001034322.2.
    UniGenei Bt.4797.

    3D structure databases

    ProteinModelPortali Q9TRY0.
    SMRi Q9TRY0. Positions 16-425.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9TRY0. 1 interaction.

    Proteomic databases

    PaxDbi Q9TRY0.
    PRIDEi Q9TRY0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 508535.
    KEGGi bta:508535.

    Organism-specific databases

    CTDi 2288.

    Phylogenomic databases

    eggNOGi COG0545.
    HOGENOMi HOG000256916.
    HOVERGENi HBG051624.
    InParanoidi Q9TRY0.
    KOi K09571.

    Miscellaneous databases

    NextBioi 20868562.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00254. FKBP_C. 2 hits.
    PF00515. TPR_1. 1 hit.
    [Graphical view ]
    SMARTi SM00028. TPR. 3 hits.
    [Graphical view ]
    PROSITEi PS50059. FKBP_PPIASE. 2 hits.
    PS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.
    3. "Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes."
      Peattie D.A., Harding M.W., Fleming M.A., Decenzo M.T., Lippke J.A., Livingston D.J., Benasutti M.
      Proc. Natl. Acad. Sci. U.S.A. 89:10974-10978(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-28; 75-83; 89-98; 122-137; 164-175; 214-222; 245-250; 277-282; 345-354; 410-424 AND 427-440.
      Tissue: Thymus.
    4. "The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13."
      Yem A.W., Tomasselli A.G., Heinrikson R.L., Zurcher-Neely H., Ruff V.A., Johnson R.A., Deibel M.R. Jr.
      J. Biol. Chem. 267:2868-2871(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-18 AND 121-137.
      Tissue: Thymus.

    Entry informationi

    Entry nameiFKBP4_BOVIN
    AccessioniPrimary (citable) accession number: Q9TRY0
    Secondary accession number(s): A5D9B2, Q3T0C4, Q9TRX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 103 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3