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Protein

Peripheral myelin protein 22

Gene

PMP22

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Might be involved in growth regulation, and in myelinization in the peripheral nervous system.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Growth arrest

Names & Taxonomyi

Protein namesi
Recommended name:
Peripheral myelin protein 22
Short name:
PMP-22
Alternative name(s):
PAS positive glycoprotein
Short name:
PASII
Gene namesi
Name:PMP22
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 11CytoplasmicSequence analysis
Transmembranei2 – 3130HelicalBy similarityAdd
BLAST
Topological domaini32 – 6433ExtracellularSequence analysisAdd
BLAST
Transmembranei65 – 9127HelicalBy similarityAdd
BLAST
Topological domaini92 – 954CytoplasmicSequence analysis
Transmembranei96 – 11924HelicalBy similarityAdd
BLAST
Topological domaini120 – 13314ExtracellularSequence analysisAdd
BLAST
Transmembranei134 – 15623HelicalBy similarityAdd
BLAST
Topological domaini157 – 1604CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160Peripheral myelin protein 22PRO_0000164648Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...) (complex)1 PublicationCAR_000191

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9TQZ3.

PTM databases

UniCarbKBiQ9TQZ3.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025389.

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWVJ. Eukaryota.
ENOG4111SX3. LUCA.
GeneTreeiENSGT00510000046328.
HOGENOMiHOG000059542.
HOVERGENiHBG001690.
InParanoidiQ9TQZ3.
KOiK19289.
OMAiAIFTVRH.
OrthoDBiEOG7034KD.
TreeFamiTF330414.

Family and domain databases

InterProiIPR003936. PMP22.
IPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PANTHERiPTHR10671:SF7. PTHR10671:SF7. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01453. EPMEMFAMILY.
PR01458. PMYELIN22.
PROSITEiPS01221. PMP22_1. 1 hit.
PS01222. PMP22_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TQZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLLGIIV LHVAVLVLLF VSTIVSQWMV GNGHATDLWQ NCSTSLMGSV
60 70 80 90 100
QHCFSSSANE WLQSVQATMI LSIIFSVLSL FLFFCQLFTL TKGGRFYITG
110 120 130 140 150
VFQILAGLCV MSAASIYTVR HPEWHFNSDG SYGFAYILAW VAFPLALLSG
160
VIYVILRKRE
Length:160
Mass (Da):17,803
Last modified:February 10, 2009 - v2
Checksum:i428B538661AD4AC3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221P → L AA sequence (PubMed:7568893).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC148075 mRNA. Translation: AAI48076.1.
RefSeqiNP_001094626.1. NM_001101156.1.
XP_005220437.1. XM_005220380.3.
XP_010814341.1. XM_010816039.2.
UniGeneiBt.22534.

Genome annotation databases

EnsembliENSBTAT00000025389; ENSBTAP00000025389; ENSBTAG00000019070.
GeneIDi534497.
KEGGibta:534497.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC148075 mRNA. Translation: AAI48076.1.
RefSeqiNP_001094626.1. NM_001101156.1.
XP_005220437.1. XM_005220380.3.
XP_010814341.1. XM_010816039.2.
UniGeneiBt.22534.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025389.

PTM databases

UniCarbKBiQ9TQZ3.

Proteomic databases

PaxDbiQ9TQZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000025389; ENSBTAP00000025389; ENSBTAG00000019070.
GeneIDi534497.
KEGGibta:534497.

Organism-specific databases

CTDi5376.

Phylogenomic databases

eggNOGiENOG410IWVJ. Eukaryota.
ENOG4111SX3. LUCA.
GeneTreeiENSGT00510000046328.
HOGENOMiHOG000059542.
HOVERGENiHBG001690.
InParanoidiQ9TQZ3.
KOiK19289.
OMAiAIFTVRH.
OrthoDBiEOG7034KD.
TreeFamiTF330414.

Miscellaneous databases

NextBioi20876422.

Family and domain databases

InterProiIPR003936. PMP22.
IPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PANTHERiPTHR10671:SF7. PTHR10671:SF7. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01453. EPMEMFAMILY.
PR01458. PMYELIN22.
PROSITEiPS01221. PMP22_1. 1 hit.
PS01222. PMP22_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal muscle.
  2. "Structure and function of peripheral nerve myelin proteins."
    Uyemura K., Asou H., Takeda Y.
    Prog. Brain Res. 105:311-318(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-44 AND 93-123.
    Tissue: Peripheral nerve.
  3. "Structure of a major oligosaccharide of PASII/PMP22 glycoprotein in bovine peripheral nerve myelin."
    Kitamura K., Uyemura K., Shibuya K., Sakamoto Y., Yoshimura K., Nomura M.
    J. Neurochem. 75:853-860(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-41, STRUCTURE OF CARBOHYDRATES.

Entry informationi

Entry nameiPMP22_BOVIN
AccessioniPrimary (citable) accession number: Q9TQZ3
Secondary accession number(s): A6QLT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 10, 2009
Last modified: May 11, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.