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Protein

Peripheral myelin protein 22

Gene

PMP22

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Might be involved in growth regulation, and in myelinization in the peripheral nervous system.

GO - Biological processi

Keywordsi

Biological processCell cycle, Growth arrest

Names & Taxonomyi

Protein namesi
Recommended name:
Peripheral myelin protein 22
Short name:
PMP-22
Alternative name(s):
PAS positive glycoprotein
Short name:
PASII
Gene namesi
Name:PMP22
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:33074. PMP22.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1CytoplasmicSequence analysis1
Transmembranei2 – 31HelicalBy similarityAdd BLAST30
Topological domaini32 – 64ExtracellularSequence analysisAdd BLAST33
Transmembranei65 – 91HelicalBy similarityAdd BLAST27
Topological domaini92 – 95CytoplasmicSequence analysis4
Transmembranei96 – 119HelicalBy similarityAdd BLAST24
Topological domaini120 – 133ExtracellularSequence analysisAdd BLAST14
Transmembranei134 – 156HelicalBy similarityAdd BLAST23
Topological domaini157 – 160CytoplasmicSequence analysis4

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646481 – 160Peripheral myelin protein 22Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
GlycosylationiCAR_00019141N-linked (GlcNAc...) (complex) asparagine1 Publication1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9TQZ3.
PRIDEiQ9TQZ3.

PTM databases

UniCarbKBiQ9TQZ3.

Expressioni

Gene expression databases

BgeeiENSBTAG00000019070.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025389.

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWVJ. Eukaryota.
ENOG4111SX3. LUCA.
GeneTreeiENSGT00510000046328.
HOGENOMiHOG000059542.
HOVERGENiHBG001690.
InParanoidiQ9TQZ3.
KOiK19289.
OMAiRFYITGV.
OrthoDBiEOG091G0RF4.
TreeFamiTF330414.

Family and domain databases

InterProiView protein in InterPro
IPR003936. PMP22.
IPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
PANTHERiPTHR10671:SF7. PTHR10671:SF7. 1 hit.
PfamiView protein in Pfam
PF00822. PMP22_Claudin. 1 hit.
PRINTSiPR01453. EPMEMFAMILY.
PR01458. PMYELIN22.
PROSITEiView protein in PROSITE
PS01221. PMP22_1. 1 hit.
PS01222. PMP22_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9TQZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLLGIIV LHVAVLVLLF VSTIVSQWMV GNGHATDLWQ NCSTSLMGSV
60 70 80 90 100
QHCFSSSANE WLQSVQATMI LSIIFSVLSL FLFFCQLFTL TKGGRFYITG
110 120 130 140 150
VFQILAGLCV MSAASIYTVR HPEWHFNSDG SYGFAYILAW VAFPLALLSG
160
VIYVILRKRE
Length:160
Mass (Da):17,803
Last modified:February 10, 2009 - v2
Checksum:i428B538661AD4AC3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122P → L AA sequence (PubMed:7568893).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC148075 mRNA. Translation: AAI48076.1.
RefSeqiNP_001094626.1. NM_001101156.1.
XP_005220437.1. XM_005220380.3.
XP_010814341.1. XM_010816039.2.
UniGeneiBt.22534.

Genome annotation databases

EnsembliENSBTAT00000025389; ENSBTAP00000025389; ENSBTAG00000019070.
GeneIDi534497.
KEGGibta:534497.

Similar proteinsi

Entry informationi

Entry nameiPMP22_BOVIN
AccessioniPrimary (citable) accession number: Q9TQZ3
Secondary accession number(s): A6QLT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 10, 2009
Last modified: March 28, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome