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Protein

Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

Gene

DHDH

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH.
D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei71May play an important role in coenzyme bindingBy similarity1
Sitei79May play an important role in coenzyme bindingBy similarity1
Sitei97May play an important role in coenzyme bindingBy similarity1
Sitei176May play an important role for the adaptation of the alcohol substrate into the binding siteBy similarity1
Sitei180May play an important role in catalytic activityBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BRENDAi1.1.1.179. 1793.
1.3.1.20. 1793.

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC:1.3.1.20)
Alternative name(s):
Cmo2DD
D-xylose 1-dehydrogenase
D-xylose-NADP dehydrogenase (EC:1.1.1.179)
Dimeric dihydrodiol dehydrogenase
Gene namesi
Name:DHDH
Synonyms:2DD
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi148R → A: No effect on activity. Reduced activity and exhibits significant temperature sensitivity; when associated with A-202. 1 Publication1
Mutagenesisi202R → A: No effect on activity. Reduced activity and exhibits significant temperature sensitivity; when associated with A-148. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003153621 – 334Trans-1,2-dihydrobenzene-1,2-diol dehydrogenaseAdd BLAST334

Expressioni

Tissue specificityi

Kidney.1 Publication

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

Secondary structure

1334
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Helixi12 – 21Combined sources10
Turni26 – 28Combined sources3
Beta strandi29 – 35Combined sources7
Helixi39 – 49Combined sources11
Beta strandi54 – 57Combined sources4
Helixi58 – 63Combined sources6
Beta strandi69 – 72Combined sources4
Helixi76 – 78Combined sources3
Helixi79 – 88Combined sources10
Beta strandi92 – 102Combined sources11
Helixi103 – 115Combined sources13
Beta strandi120 – 123Combined sources4
Helixi125 – 128Combined sources4
Helixi130 – 141Combined sources12
Turni142 – 144Combined sources3
Beta strandi146 – 155Combined sources10
Helixi162 – 165Combined sources4
Turni167 – 170Combined sources4
Helixi173 – 176Combined sources4
Helixi178 – 188Combined sources11
Turni189 – 191Combined sources3
Beta strandi195 – 203Combined sources9
Beta strandi207 – 218Combined sources12
Turni219 – 221Combined sources3
Beta strandi222 – 232Combined sources11
Beta strandi238 – 242Combined sources5
Beta strandi245 – 249Combined sources5
Beta strandi258 – 261Combined sources4
Beta strandi264 – 267Combined sources4
Helixi282 – 285Combined sources4
Helixi286 – 297Combined sources12
Beta strandi304 – 306Combined sources3
Helixi308 – 324Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O48X-ray2.59X1-334[»]
2O4UX-ray2.00X1-334[»]
2POQX-ray2.59X1-334[»]
3OHSX-ray1.90X1-334[»]
ProteinModelPortaliQ9TQS6.
SMRiQ9TQS6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9TQS6.

Family & Domainsi

Sequence similaritiesi

Belongs to the Gfo/Idh/MocA family.Curated

Phylogenomic databases

HOVERGENiHBG105348.
KOiK00078.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9TQS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRWGIVSV GLISSDFTAV LQTLPRSEHQ VVAVAARDLS RAKEFAQKHD
60 70 80 90 100
IPKAYGSYEE LAKDPNVEVA YVGTQHPQHK AAVMLCLAAG KAVLCEKPMG
110 120 130 140 150
VNAAEVREMV TEARSRGLFL MEAIWTRFFP ASEALRSVLA QGTLGDLRVA
160 170 180 190 200
RAEFGKNLTH VPRAVDWAQA GGALLDLGIY CVQFISMVFG GQKPEKISVM
210 220 230 240 250
GRRHETGVDD TVTVLLQYPG EVHGSFTCSI TAQLSNTASV SGTKGMAQLL
260 270 280 290 300
NPCWCPTELV VKGEHKEFLL PPVPKNCNFD NGAGMSYEAK HVRECLRKGL
310 320 330
KESPVIPLVE SELLADILEE VRRAIGVTFP QDKH
Length:334
Mass (Da):36,435
Last modified:May 1, 2000 - v1
Checksum:iD319AF45660667C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021932 mRNA. Translation: BAA83489.1.
RefSeqiNP_001271017.1. NM_001284088.1.
UniGeneiMfa.5414.

Genome annotation databases

GeneIDi102133381.
KEGGimcf:102133381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021932 mRNA. Translation: BAA83489.1.
RefSeqiNP_001271017.1. NM_001284088.1.
UniGeneiMfa.5414.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O48X-ray2.59X1-334[»]
2O4UX-ray2.00X1-334[»]
2POQX-ray2.59X1-334[»]
3OHSX-ray1.90X1-334[»]
ProteinModelPortaliQ9TQS6.
SMRiQ9TQS6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102133381.
KEGGimcf:102133381.

Organism-specific databases

CTDi27294.

Phylogenomic databases

HOVERGENiHBG105348.
KOiK00078.

Enzyme and pathway databases

BRENDAi1.1.1.179. 1793.
1.3.1.20. 1793.

Miscellaneous databases

EvolutionaryTraceiQ9TQS6.
PROiQ9TQS6.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDHDH_MACFA
AccessioniPrimary (citable) accession number: Q9TQS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.