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Q9TQA6

- Q9TQA6_RAT

UniProt

Q9TQA6 - Q9TQA6_RAT

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Protein
Submitted name:

Class II MHC RT1.D(N) beta chain

Gene
RT1-Db1, Arrb2-ps, Db1, Hla-dma, Hla-dmb, Psmb9, RT1-Ba, RT1-Bb, RT1-Da, RT1-Db, RT1-Db2, RT1-DOb, RT1.D(n), Tap1, Tap2, Tesb, rCG_60985
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Ensembl
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
Class II MHC RT1.D(N) beta chainImported
Submitted name:
MHC class II antigenImported
Submitted name:
RCG60985, isoform CRA_aImported
Submitted name:
RT1 class II, D beta 1Imported
Submitted name:
RT1-Db1Imported
Submitted name:
Rano class II histocompatibility antigen, D-1 beta chainImported
Gene namesi
Name:RT1-Db1Imported
Synonyms:Arrb2-psImported, Db1Imported, Hla-dmaImported, Hla-dmbImported, Psmb9Imported, RT1-BaImported, RT1-BbImported, RT1-DaImported, RT1-DbImported, RT1-Db2Imported, RT1-DObImported, RT1.D(n)Imported, Tap1Imported, Tap2Imported, TesbImported
ORF Names:rCG_60985Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 20

Organism-specific databases

RGDi1593282. RT1-Db1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. MHC class II protein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IIUniRule annotationSAAS annotations

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 PredictedImportedAdd
BLAST
Chaini27 – 264238Class II MHC RT1.D(n) beta chainImportedPRO_5000055051Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotations

Expressioni

Gene expression databases

GenevestigatoriQ9TQA6.

Family & Domainsi

Sequence similaritiesi

Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotations

Keywords - Domaini

SignalImported, Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00560000076676.
HOVERGENiHBG012730.
InParanoidiQ9TQA6.
KOiK06752.
OMAiNGMERVR.
OrthoDBiEOG7PS1GV.
TreeFamiTF336626.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9TQA6-1 [UniParc]FASTAAdd to Basket

« Hide

MVWLARDSCV AAVILLLTVL SPPVALVRDP TPRFLEQYKS ECYFYNGTQR    50
VRLLVRYIYN REEYTRFDSD VGEFRAVTEL GRRDTEYYNK QKEYIERERA 100
AVDTICRHNY EISDRFLVPR TVEPKVTVYP SKTQPLKHHN LLVCSVSDFY 150
PGSVEVRWFR NGEEEKDGLV STGLIPNGDW TFQLLVMLEM VPQGGEVYTC 200
QVEHPSLTSP VRVEWKAQST SAQNKKMSGV GGIVLGLLFL GAGLFVYFRN 250
QKGQSGLQPT GLLN 264
Length:264
Mass (Da):30,202
Last modified:May 1, 2000 - v1
Checksum:iC57FCD5C5CBF0FB3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06099861 Genomic DNA. No translation available.
AF084933 mRNA. Translation: AAD39083.1.
AY626207 mRNA. Translation: AAV40636.1.
KC222950 mRNA. Translation: AGV39047.1.
BX883043 Genomic DNA. Translation: CAE83947.1.
CH473988 Genomic DNA. Translation: EDL96798.1.
RefSeqiNP_001008884.1. NM_001008884.2.
UniGeneiRn.33311.

Genome annotation databases

EnsembliENSRNOT00000000522; ENSRNOP00000000522; ENSRNOG00000033215.
GeneIDi294270.
KEGGirno:294270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06099861 Genomic DNA. No translation available.
AF084933 mRNA. Translation: AAD39083.1 .
AY626207 mRNA. Translation: AAV40636.1 .
KC222950 mRNA. Translation: AGV39047.1 .
BX883043 Genomic DNA. Translation: CAE83947.1 .
CH473988 Genomic DNA. Translation: EDL96798.1 .
RefSeqi NP_001008884.1. NM_001008884.2.
UniGenei Rn.33311.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000000522 ; ENSRNOP00000000522 ; ENSRNOG00000033215 .
GeneIDi 294270.
KEGGi rno:294270.

Organism-specific databases

CTDi 294270.
RGDi 1593282. RT1-Db1.

Phylogenomic databases

GeneTreei ENSGT00560000076676.
HOVERGENi HBG012730.
InParanoidi Q9TQA6.
KOi K06752.
OMAi NGMERVR.
OrthoDBi EOG7PS1GV.
TreeFami TF336626.

Miscellaneous databases

NextBioi 637862.

Gene expression databases

Genevestigatori Q9TQA6.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view ]
ProDomi PD000328. MHC_II_b_N. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequences of three distinct complementary DNA clones encoding rat class II major histocompatibility complex RT1.D beta-chain proteins."
    Tian L., Wang M., Yu J., Kahan B.D., Stepkowski S.M.
    Immunogenetics 49:735-737(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Brown NorwayImported.
  3. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
    Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
    Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Brown NorwayImported.
  4. "Open reading frame sequencing and structure-based alignment of polypeptides encoded by RT1-Bb, RT1-Ba, RT1-Db, and RT1-Da alleles."
    Ettinger R.A., Moustakas A.K., Lobaton S.D.
    Immunogenetics 56:585-596(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BN/CrlBRImported.
    Tissue: ThymusImported.
  5. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  8. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DA.1HImported.

Entry informationi

Entry nameiQ9TQA6_RAT
AccessioniPrimary (citable) accession number: Q9TQA6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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