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Protein
Submitted name:

Class II MHC RT1.D(N) beta chain

Gene

RT1-Db1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-RNO-202424. Downstream TCR signaling.
R-RNO-202427. Phosphorylation of CD3 and TCR zeta chains.
R-RNO-202430. Translocation of ZAP-70 to Immunological synapse.
R-RNO-202433. Generation of second messenger molecules.
R-RNO-2132295. MHC class II antigen presentation.
R-RNO-389948. PD-1 signaling.
R-RNO-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Class II MHC RT1.D(N) beta chainImported
Submitted name:
MHC class II antigenImported
Submitted name:
RCG60985, isoform CRA_aImported
Submitted name:
RT1 class II, D beta 1Imported
Submitted name:
RT1-Db1Imported
Submitted name:
Rano class II histocompatibility antigen, D-1 beta chainImported
Gene namesi
Name:RT1-Db1Imported
Synonyms:Arrb2-psImported, Db1Imported, Hla-dmaImported, Hla-dmbImported, Psmb9Imported, RT1-BaImported, RT1-BbImported, RT1-DaImported, RT1-DbImported, RT1-Db2Imported, RT1-DObImported, RT1.D(n)Imported, Tap1Imported, Tap2Imported, TesbImported
ORF Names:rCG_60985Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1593282. RT1-Db1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei227 – 248HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500818051627 – 264Sequence analysisAdd BLAST238

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000033215.
ExpressionAtlasiQ9TQA6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000522.

Structurei

3D structure databases

ProteinModelPortaliQ9TQA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 228Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST105

Sequence similaritiesi

Belongs to the MHC class II family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IWG3. Eukaryota.
ENOG410YI0S. LUCA.
GeneTreeiENSGT00760000118970.
HOVERGENiHBG012730.
KOiK06752.
OMAiTMEMANG.
OrthoDBiEOG091G15IU.
TreeFamiTF336626.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TQA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWLARDSCV AAVILLLTVL SPPVALVRDP TPRFLEQYKS ECYFYNGTQR
60 70 80 90 100
VRLLVRYIYN REEYTRFDSD VGEFRAVTEL GRRDTEYYNK QKEYIERERA
110 120 130 140 150
AVDTICRHNY EISDRFLVPR TVEPKVTVYP SKTQPLKHHN LLVCSVSDFY
160 170 180 190 200
PGSVEVRWFR NGEEEKDGLV STGLIPNGDW TFQLLVMLEM VPQGGEVYTC
210 220 230 240 250
QVEHPSLTSP VRVEWKAQST SAQNKKMSGV GGIVLGLLFL GAGLFVYFRN
260
QKGQSGLQPT GLLN
Length:264
Mass (Da):30,202
Last modified:May 1, 2000 - v1
Checksum:iC57FCD5C5CBF0FB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072809 Genomic DNA. No translation available.
AF084933 mRNA. Translation: AAD39083.1.
AY626207 mRNA. Translation: AAV40636.1.
KC222950 mRNA. Translation: AGV39047.1.
BX883043 Genomic DNA. Translation: CAE83947.1.
CH473988 Genomic DNA. Translation: EDL96798.1.
RefSeqiNP_001008884.1. NM_001008884.2.
UniGeneiRn.33311.

Genome annotation databases

EnsembliENSRNOT00000000522; ENSRNOP00000000522; ENSRNOG00000033215.
GeneIDi294270.
KEGGirno:294270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072809 Genomic DNA. No translation available.
AF084933 mRNA. Translation: AAD39083.1.
AY626207 mRNA. Translation: AAV40636.1.
KC222950 mRNA. Translation: AGV39047.1.
BX883043 Genomic DNA. Translation: CAE83947.1.
CH473988 Genomic DNA. Translation: EDL96798.1.
RefSeqiNP_001008884.1. NM_001008884.2.
UniGeneiRn.33311.

3D structure databases

ProteinModelPortaliQ9TQA6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000522.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000522; ENSRNOP00000000522; ENSRNOG00000033215.
GeneIDi294270.
KEGGirno:294270.

Organism-specific databases

CTDi294270.
RGDi1593282. RT1-Db1.

Phylogenomic databases

eggNOGiENOG410IWG3. Eukaryota.
ENOG410YI0S. LUCA.
GeneTreeiENSGT00760000118970.
HOVERGENiHBG012730.
KOiK06752.
OMAiTMEMANG.
OrthoDBiEOG091G15IU.
TreeFamiTF336626.

Enzyme and pathway databases

ReactomeiR-RNO-202424. Downstream TCR signaling.
R-RNO-202427. Phosphorylation of CD3 and TCR zeta chains.
R-RNO-202430. Translocation of ZAP-70 to Immunological synapse.
R-RNO-202433. Generation of second messenger molecules.
R-RNO-2132295. MHC class II antigen presentation.
R-RNO-389948. PD-1 signaling.
R-RNO-877300. Interferon gamma signaling.

Gene expression databases

BgeeiENSRNOG00000033215.
ExpressionAtlasiQ9TQA6. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9TQA6_RAT
AccessioniPrimary (citable) accession number: Q9TQA6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.