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Protein

Elongation factor Tu, apicoplast

Gene

tufA

Organism
Toxoplasma gondii
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTPBy similarity
Nucleotide bindingi81 – 855GTPBy similarity
Nucleotide bindingi136 – 1394GTPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor Tu, apicoplast
Short name:
EF-Tu
Gene namesi
Name:tufA
Encoded oniPlastid; Apicoplast
OrganismiToxoplasma gondii
Taxonomic identifieri5811 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma

Organism-specific databases

EuPathDBiToxoDB:TogoCp15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Apicoplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Elongation factor Tu, apicoplastPRO_0000337597Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi5811.TGME49_102050.

Structurei

3D structure databases

ProteinModelPortaliQ9TMM9.
SMRiQ9TMM9. Positions 2-400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 206197tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 268G1By similarity
Regioni60 – 645G2By similarity
Regioni81 – 844G3By similarity
Regioni136 – 1394G4By similarity
Regioni173 – 1753G5By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0460. Eukaryota.
COG0050. LUCA.
HOGENOMiHOG000229290.

Family and domain databases

CDDicd03697. EFTU_II. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR033720. EFTU_2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TMM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEIFKKQK PHINIGTIGH VDHGKTTLTA AITYVLAKNN QAKLKTYKEI
60 70 80 90 100
DCAPEEIARG ITIKTSHIEY ETAVRHYAHI DCPGHADYIK NMITGAAQMD
110 120 130 140 150
GAILVVSAVD GPMPQTKEHL LLAKQIGISN IIVFLNKIDL IDDNEILELV
160 170 180 190 200
ELETRELLDK YNFSSDTPII TGSALKALDN NLTSNIWVDK IYELLTALDS
210 220 230 240 250
YIPLPKRDLD KPFLLAIEDI FSITGRGTVV TGKIERGSIK LGDTVTMLGF
260 270 280 290 300
NISKNVVVIG LEMFQKTLEI GEAGDNVGIL LRGIQKTEVK RGMILSKPLT
310 320 330 340 350
MTLHSIFQAD VYILTVAEGG REKPIFEGYC PQFYLYTINI TGSIKFSSET
360 370 380 390 400
KETGTKMILP GDRVKLNVTL IYSIAMEKGM RFAIREGGRT IGAGIITDII

K
Length:401
Mass (Da):44,313
Last modified:May 1, 2000 - v1
Checksum:iC7CCF9B7ACF7530F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti376 – 3761M → I in CAA72239 (Ref. 2) Curated
Sequence conflicti376 – 3761M → I in CAA61254 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X88775 Genomic DNA. Translation: CAA61254.1.
Y11431 Genomic DNA. Translation: CAA72239.1.
U87145 Genomic DNA. Translation: AAD41145.1.
RefSeqiNP_044559.1. NC_001799.1.

Genome annotation databases

GeneIDi1466608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X88775 Genomic DNA. Translation: CAA61254.1.
Y11431 Genomic DNA. Translation: CAA72239.1.
U87145 Genomic DNA. Translation: AAD41145.1.
RefSeqiNP_044559.1. NC_001799.1.

3D structure databases

ProteinModelPortaliQ9TMM9.
SMRiQ9TMM9. Positions 2-400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5811.TGME49_102050.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1466608.

Organism-specific databases

EuPathDBiToxoDB:TogoCp15.

Phylogenomic databases

eggNOGiKOG0460. Eukaryota.
COG0050. LUCA.
HOGENOMiHOG000229290.

Family and domain databases

CDDicd03697. EFTU_II. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR033720. EFTU_2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEFTU_TOXGO
AccessioniPrimary (citable) accession number: Q9TMM9
Secondary accession number(s): O78325, Q26114
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.