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Protein

Ferredoxin-thioredoxin reductase, catalytic chain

Gene

ftrB

Organism
Cyanidium caldarium (Red alga)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.By similarity

Catalytic activityi

2 reduced ferredoxin + thioredoxin disulfide = 2 oxidized ferredoxin + thioredoxin + 2 H+.

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52Iron-sulfur (4Fe-4S)By similarity1
Active sitei54NucleophileBy similarity1
Metal bindingi71Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi73Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi82Iron-sulfur (4Fe-4S)By similarity1
Sitei83Increases the nucleophilicity of the active site CysBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferredoxin-thioredoxin reductase, catalytic chain (EC:1.8.7.2)
Short name:
FTR-C
Alternative name(s):
Ferredoxin-thioredoxin reductase subunit B
Short name:
FTR-B
Gene namesi
Name:ftrB
Encoded oniPlastid; Chloroplast
OrganismiCyanidium caldarium (Red alga)
Taxonomic identifieri2771 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaBangiophyceaeCyanidialesCyanidiaceaeCyanidium

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001676711 – 111Ferredoxin-thioredoxin reductase, catalytic chainAdd BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 84Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9TM25

Interactioni

Subunit structurei

Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9TM25
SMRiQ9TM25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Family and domain databases

Gene3Di3.90.460.10, 1 hit
InterProiView protein in InterPro
IPR024707 FTR_bsu
IPR004209 FTR_bsu_dom
IPR036644 FTR_bsu_sf
PfamiView protein in Pfam
PF02943 FeThRed_B, 1 hit
PIRSFiPIRSF000260 FTRc, 1 hit
SUPFAMiSSF57662 SSF57662, 1 hit

Sequencei

Sequence statusi: Complete.

Q9TM25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKTPKNLES LHKFAEAYAK LSRTYFCIDQ SITALVIEGL ARHKDDYGAP
60 70 80 90 100
LCPCRHYENK KTEVLAAYWN CPCVPMRERK ECHCMLFLQP SNEFSGESQL
110
ISKDDLQKHL S
Length:111
Mass (Da):12,867
Last modified:May 1, 2000 - v1
Checksum:i34F9E68E92C8E407
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022186 Genomic DNA Translation: AAF13004.1
RefSeqiNP_045042.1, NC_001840.1

Genome annotation databases

GeneIDi800142

Similar proteinsi

Entry informationi

Entry nameiFTRC_CYACA
AccessioniPrimary (citable) accession number: Q9TM25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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