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Q9TLX4 (LPXA_CYACA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Short name=UDP-N-acetylglucosamine acyltransferase
EC=2.3.1.129
Gene names
Name:lpxA
Encoded onPlastid; Chloroplast
OrganismCyanidium caldarium
Taxonomic identifier2771 [NCBI]
Taxonomic lineageEukaryotaRhodophytaBangiophyceaeCyanidialesCyanidiaceaeCyanidium

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. The target for the lipopolysaccharides produced in the chloroplast could either be the cell envelope of the eukaryote or the plastid membrane Potential. HAMAP-Rule MF_00387

Catalytic activity

(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine. HAMAP-Rule MF_00387

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. HAMAP-Rule MF_00387

Subunit structure

Homotrimer By similarity. HAMAP-Rule MF_00387

Subcellular location

Plastidchloroplast HAMAP-Rule MF_00387.

Sequence similarities

Belongs to the transferase hexapeptide repeat family. LpxA subfamily.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Cellular componentChloroplast
Plastid
   DomainRepeat
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentchloroplast

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionacyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase HAMAP-Rule MF_00387
PRO_0000188082

Sequences

Sequence LengthMass (Da)Tools
Q9TLX4 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 7DC42DD00AD0DF7B

FASTA26929,377
        10         20         30         40         50         60 
MTNIHSTAIV HPAASLGRNV VVGPYSIIGS DVSIGDYTRI GPHVVITGKT VIGCNNQILS 

        70         80         90        100        110        120 
GCILGSVPQD LRYIDSELTG LYIGNNNLIR ENVTVHRASG NGVTYIGNNN LIMVNCHVAH 

       130        140        150        160        170        180 
DCQIRNNIII SNSVSLAGHV IIDSCVIIGG HAGLHQFVHV GALSMIAAMS KIEKNVLPFV 

       190        200        210        220        230        240 
VVSGMPAITR TINLVGLKRY GISKTDINYI RLMLENLKVQ PLAFDTYSIF KKFKSDNLLK 

       250        260 
RNVAVQYFSD FLFNSFRARG FIPFKVPKK 

« Hide

References

[1]"The structure and gene repertoire of an ancient red algal plastid genome."
Gloeckner G., Rosenthal A., Valentin K.-U.
J. Mol. Evol. 51:382-390(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RK-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF022186 Genomic DNA. Translation: AAF12950.1.
RefSeqNP_045144.1. NC_001840.1.

3D structure databases

ProteinModelPortalQ9TLX4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID800145.

Enzyme and pathway databases

UniPathwayUPA00359; UER00477.

Family and domain databases

HAMAPMF_00387. LpxA.
InterProIPR029098. Acetyltransf_C.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR010137. Lipid_A_LpxA.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamPF13720. Acetyltransf_11. 1 hit.
PF00132. Hexapep. 2 hits.
[Graphical view]
PIRSFPIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAMSSF51161. SSF51161. 1 hit.
TIGRFAMsTIGR01852. lipid_A_lpxA. 1 hit.
PROSITEPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLPXA_CYACA
AccessionPrimary (citable) accession number: Q9TLX4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways