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Q9TGE6 (COX1_LOLFO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COI
Encoded onMitochondrion
OrganismLoligo forbesi (Northern European squid)
Taxonomic identifier6618 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaDecapodiformesTeuthidaMyopsinaLoliginidaeLoligo

Protein attributes

Sequence length213 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›213›213Cytochrome c oxidase subunit 1
PRO_0000183355

Regions

Transmembrane1 – 2121Helical; Name=1; Potential
Topological domain22 – 4221Mitochondrial intermembrane Potential
Transmembrane43 – 6321Helical; Name=2; Potential
Topological domain64 – 8118Mitochondrial matrix Potential
Transmembrane82 – 10221Helical; Name=3; Potential
Topological domain103 – 12422Mitochondrial intermembrane Potential
Transmembrane125 – 14521Helical; Name=4; Potential
Topological domain146 – 16217Mitochondrial matrix Potential
Transmembrane163 – 18321Helical; Name=5; Potential
Topological domain184 – 21330Mitochondrial intermembrane Potential

Sites

Metal binding411Iron (heme A axial ligand) Probable

Experimental info

Non-terminal residue11
Non-terminal residue2131

Sequences

Sequence LengthMass (Da)Tools
Q9TGE6 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: FEB1ECFDE5EC1997

FASTA21323,084
        10         20         30         40         50         60 
IFGIWAGLVG TSLSLMIRTE LGKPGSLLND DQLYNVVVTA HGFIMIFFMV MPIMIGGFGN 

        70         80         90        100        110        120 
WLVPLMLGAP DMAFPRMNNM SFWLLPPSLT LLLASSAVES GAGTGWTVYP PLSSNLSHAG 

       130        140        150        160        170        180 
PSVDLAIFSL HLAGISSILG AINFITTIMN MRWEGLLMER MSLFVWSVFI TAILLLLSLP 

       190        200        210 
VLAGAITMLL TDRNFNTTFF DPSGGGDPIL YQH 

« Hide

References

[1]"Phylogeny and historical biogeography of the loliginid squids (Mollusca: Cephalopoda) based on mitochondrial DNA sequence data."
Anderson F.E.
Mol. Phylogenet. Evol. 15:191-214(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF075402 Genomic DNA. Translation: AAD46709.1.

3D structure databases

ProteinModelPortalQ9TGE6.
SMRQ9TGE6. Positions 1-213.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_LOLFO
AccessionPrimary (citable) accession number: Q9TGE6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways