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Q9TGE6

- COX1_LOLFO

UniProt

Q9TGE6 - COX1_LOLFO

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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Loligo forbesi (Northern European squid)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi41 – 411Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiLoligo forbesi (Northern European squid)
Taxonomic identifieri6618 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaDecapodiformesTeuthidaMyopsinaLoliginidaeLoligo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›213›213Cytochrome c oxidase subunit 1PRO_0000183355Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9TGE6.
SMRiQ9TGE6. Positions 1-213.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 4221Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini64 – 8118Mitochondrial matrixSequence AnalysisAdd
BLAST
Topological domaini103 – 12422Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini146 – 16217Mitochondrial matrixSequence AnalysisAdd
BLAST
Topological domaini184 – 21330Mitochondrial intermembraneSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei43 – 6321Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei82 – 10221Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei125 – 14521Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei163 – 18321Helical; Name=5Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9TGE6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
IFGIWAGLVG TSLSLMIRTE LGKPGSLLND DQLYNVVVTA HGFIMIFFMV
60 70 80 90 100
MPIMIGGFGN WLVPLMLGAP DMAFPRMNNM SFWLLPPSLT LLLASSAVES
110 120 130 140 150
GAGTGWTVYP PLSSNLSHAG PSVDLAIFSL HLAGISSILG AINFITTIMN
160 170 180 190 200
MRWEGLLMER MSLFVWSVFI TAILLLLSLP VLAGAITMLL TDRNFNTTFF
210
DPSGGGDPIL YQH
Length:213
Mass (Da):23,084
Last modified:May 1, 2000 - v1
Checksum:iFEB1ECFDE5EC1997
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei213 – 2131

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF075402 Genomic DNA. Translation: AAD46709.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF075402 Genomic DNA. Translation: AAD46709.1 .

3D structure databases

ProteinModelPortali Q9TGE6.
SMRi Q9TGE6. Positions 1-213.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phylogeny and historical biogeography of the loliginid squids (Mollusca: Cephalopoda) based on mitochondrial DNA sequence data."
    Anderson F.E.
    Mol. Phylogenet. Evol. 15:191-214(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_LOLFO
AccessioniPrimary (citable) accession number: Q9TGE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3