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Q9TGE6

- COX1_LOLFO

UniProt

Q9TGE6 - COX1_LOLFO

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Protein

Cytochrome c oxidase subunit 1

Gene
COI
Organism
Loligo forbesi (Northern European squid)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi41 – 411Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiLoligo forbesi (Northern European squid)
Taxonomic identifieri6618 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaDecapodiformesTeuthidaMyopsinaLoliginidaeLoligo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini22 – 4221Mitochondrial intermembrane Reviewed predictionAdd
BLAST
Transmembranei43 – 6321Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini64 – 8118Mitochondrial matrix Reviewed predictionAdd
BLAST
Transmembranei82 – 10221Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini103 – 12422Mitochondrial intermembrane Reviewed predictionAdd
BLAST
Transmembranei125 – 14521Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini146 – 16217Mitochondrial matrix Reviewed predictionAdd
BLAST
Transmembranei163 – 18321Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini184 – 21330Mitochondrial intermembrane Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›213›213Cytochrome c oxidase subunit 1PRO_0000183355Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9TGE6.
SMRiQ9TGE6. Positions 1-213.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9TGE6-1 [UniParc]FASTAAdd to Basket

« Hide

IFGIWAGLVG TSLSLMIRTE LGKPGSLLND DQLYNVVVTA HGFIMIFFMV    50
MPIMIGGFGN WLVPLMLGAP DMAFPRMNNM SFWLLPPSLT LLLASSAVES 100
GAGTGWTVYP PLSSNLSHAG PSVDLAIFSL HLAGISSILG AINFITTIMN 150
MRWEGLLMER MSLFVWSVFI TAILLLLSLP VLAGAITMLL TDRNFNTTFF 200
DPSGGGDPIL YQH 213
Length:213
Mass (Da):23,084
Last modified:May 1, 2000 - v1
Checksum:iFEB1ECFDE5EC1997
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei213 – 2131

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF075402 Genomic DNA. Translation: AAD46709.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF075402 Genomic DNA. Translation: AAD46709.1 .

3D structure databases

ProteinModelPortali Q9TGE6.
SMRi Q9TGE6. Positions 1-213.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phylogeny and historical biogeography of the loliginid squids (Mollusca: Cephalopoda) based on mitochondrial DNA sequence data."
    Anderson F.E.
    Mol. Phylogenet. Evol. 15:191-214(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_LOLFO
AccessioniPrimary (citable) accession number: Q9TGE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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