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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Loligo forbesi (Northern European squid)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi41Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiLoligo forbesi (Northern European squid)
Taxonomic identifieri6618 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaDecapodiformesTeuthidaMyopsinaLoliginidaeLoligo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini22 – 42Mitochondrial intermembraneSequence analysisAdd BLAST21
Transmembranei43 – 63Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini64 – 81Mitochondrial matrixSequence analysisAdd BLAST18
Transmembranei82 – 102Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini103 – 124Mitochondrial intermembraneSequence analysisAdd BLAST22
Transmembranei125 – 145Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini146 – 162Mitochondrial matrixSequence analysisAdd BLAST17
Transmembranei163 – 183Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini184 – 213Mitochondrial intermembraneSequence analysisAdd BLAST30

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000183355‹1 – ›213Cytochrome c oxidase subunit 1Add BLAST›213

Structurei

3D structure databases

ProteinModelPortaliQ9TGE6
SMRiQ9TGE6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit

Sequencei

Sequence statusi: Fragment.

Q9TGE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IFGIWAGLVG TSLSLMIRTE LGKPGSLLND DQLYNVVVTA HGFIMIFFMV
60 70 80 90 100
MPIMIGGFGN WLVPLMLGAP DMAFPRMNNM SFWLLPPSLT LLLASSAVES
110 120 130 140 150
GAGTGWTVYP PLSSNLSHAG PSVDLAIFSL HLAGISSILG AINFITTIMN
160 170 180 190 200
MRWEGLLMER MSLFVWSVFI TAILLLLSLP VLAGAITMLL TDRNFNTTFF
210
DPSGGGDPIL YQH
Length:213
Mass (Da):23,084
Last modified:May 1, 2000 - v1
Checksum:iFEB1ECFDE5EC1997
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei2131

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075402 Genomic DNA Translation: AAD46709.1

Similar proteinsi

Entry informationi

Entry nameiCOX1_LOLFO
AccessioniPrimary (citable) accession number: Q9TGE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

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