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Q9TC96

- NDUS2_NEPOL

UniProt

Q9TC96 - NDUS2_NEPOL

Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2

Gene

NAD7

Organism
Nephroselmis olivacea (Green alga)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    Cofactori

    Binds 1 4Fe-4S cluster.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi261 – 2611Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi267 – 2671Iron-sulfur (4Fe-4S)Sequence Analysis
    Metal bindingi282 – 2821Iron-sulfur (4Fe-4S)Sequence Analysis

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. NAD binding Source: InterPro
    4. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    5. quinone binding Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    NADH dehydrogenase subunit 7
    Gene namesi
    Name:NAD7
    Encoded oniMitochondrion
    OrganismiNephroselmis olivacea (Green alga)
    Taxonomic identifieri31312 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeChlorophytaNephroselmidophyceaeNephroselmis

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398NADH dehydrogenase [ubiquinone] iron-sulfur protein 2PRO_0000118584Add
    BLAST

    Interactioni

    Subunit structurei

    Complex I is composed of about 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9TC96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 49 kDa subunit family.Curated

    Family and domain databases

    Gene3Di1.10.645.10. 2 hits.
    HAMAPiMF_01358. NDH1_NuoD.
    InterProiIPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view]
    PfamiPF00346. Complex1_49kDa. 1 hit.
    [Graphical view]
    SUPFAMiSSF56762. SSF56762. 1 hit.
    TIGRFAMsiTIGR01962. NuoD. 1 hit.
    PROSITEiPS00535. COMPLEX1_49K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9TC96-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIEHASSIK KVKNFTLNFG PQHPAAHGVL RLVLELNGEV VARADPHIGL    50
    LHRGTEKLIE YKTYTQALPY FDRLDYVSMM CQEHAYSLAV EKLLHCEVPE 100
    RAQYIRVLFS EITRILNHLL ALTTHAMDVG ALTPFLWAFE EREKLIEFYE 150
    RVSGSRMHAA YIRPGGVACD LPANLCEDIY LFCQQFASRI DEMEEMLTNN 200
    RIWKQRLVDI GIVTAENAFA WGFSGVLLRG SGVAWDLRKT QPYDVYNRMI 250
    FDVPVGTQGD CYDRYLCRVE EMRQSIHIIM QCLNQLPKGM IKADDKKITP 300
    PSRSQMKQSM ESLIHHFKLF TEGYTVPNSE TYTSVEAPKG EFGVYLVSNG 350
    TNRPYRCKIR APGFLHLQGL DMMSKNHMLA DVVTIIGTQD IVFGEVDR 398
    Length:398
    Mass (Da):45,476
    Last modified:May 1, 2000 - v1
    Checksum:iBCBD8FE4AACB08EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF110138 Genomic DNA. Translation: AAF03201.1.
    RefSeqiYP_665674.1. NC_008239.1.

    Genome annotation databases

    GeneIDi4178038.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF110138 Genomic DNA. Translation: AAF03201.1 .
    RefSeqi YP_665674.1. NC_008239.1.

    3D structure databases

    ProteinModelPortali Q9TC96.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4178038.

    Family and domain databases

    Gene3Di 1.10.645.10. 2 hits.
    HAMAPi MF_01358. NDH1_NuoD.
    InterProi IPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view ]
    Pfami PF00346. Complex1_49kDa. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56762. SSF56762. 1 hit.
    TIGRFAMsi TIGR01962. NuoD. 1 hit.
    PROSITEi PS00535. COMPLEX1_49K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete mitochondrial DNA sequences of Nephroselmis olivacea and Pedinomonas minor: two radically different evolutionary patterns within the green algae."
      Turmel M., Lemieux C., Burger G., Lang B.F., Otis C., Plante I., Gray M.W.
      Plant Cell 11:1717-1730(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: NIES-484.

    Entry informationi

    Entry nameiNDUS2_NEPOL
    AccessioniPrimary (citable) accession number: Q9TC96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3