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Q9TC96

- NDUS2_NEPOL

UniProt

Q9TC96 - NDUS2_NEPOL

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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2

Gene

NAD7

Organism
Nephroselmis olivacea (Green alga)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

Binds 1 4Fe-4S cluster.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi261 – 2611Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi267 – 2671Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi282 – 2821Iron-sulfur (4Fe-4S)Sequence Analysis

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. NAD binding Source: InterPro
  4. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  5. quinone binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
NADH dehydrogenase subunit 7
Gene namesi
Name:NAD7
Encoded oniMitochondrion
OrganismiNephroselmis olivacea (Green alga)
Taxonomic identifieri31312 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaprasinophytesNephroselmidophyceaeNephroselmis

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398NADH dehydrogenase [ubiquinone] iron-sulfur protein 2PRO_0000118584Add
BLAST

Interactioni

Subunit structurei

Complex I is composed of about 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9TC96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.Curated

Family and domain databases

Gene3Di1.10.645.10. 2 hits.
HAMAPiMF_01358. NDH1_NuoD.
InterProiIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
SUPFAMiSSF56762. SSF56762. 1 hit.
TIGRFAMsiTIGR01962. NuoD. 1 hit.
PROSITEiPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9TC96-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIEHASSIK KVKNFTLNFG PQHPAAHGVL RLVLELNGEV VARADPHIGL
60 70 80 90 100
LHRGTEKLIE YKTYTQALPY FDRLDYVSMM CQEHAYSLAV EKLLHCEVPE
110 120 130 140 150
RAQYIRVLFS EITRILNHLL ALTTHAMDVG ALTPFLWAFE EREKLIEFYE
160 170 180 190 200
RVSGSRMHAA YIRPGGVACD LPANLCEDIY LFCQQFASRI DEMEEMLTNN
210 220 230 240 250
RIWKQRLVDI GIVTAENAFA WGFSGVLLRG SGVAWDLRKT QPYDVYNRMI
260 270 280 290 300
FDVPVGTQGD CYDRYLCRVE EMRQSIHIIM QCLNQLPKGM IKADDKKITP
310 320 330 340 350
PSRSQMKQSM ESLIHHFKLF TEGYTVPNSE TYTSVEAPKG EFGVYLVSNG
360 370 380 390
TNRPYRCKIR APGFLHLQGL DMMSKNHMLA DVVTIIGTQD IVFGEVDR
Length:398
Mass (Da):45,476
Last modified:May 1, 2000 - v1
Checksum:iBCBD8FE4AACB08EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF110138 Genomic DNA. Translation: AAF03201.1.
RefSeqiYP_665674.1. NC_008239.1.

Genome annotation databases

GeneIDi4178038.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF110138 Genomic DNA. Translation: AAF03201.1 .
RefSeqi YP_665674.1. NC_008239.1.

3D structure databases

ProteinModelPortali Q9TC96.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4178038.

Family and domain databases

Gene3Di 1.10.645.10. 2 hits.
HAMAPi MF_01358. NDH1_NuoD.
InterProi IPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view ]
Pfami PF00346. Complex1_49kDa. 1 hit.
[Graphical view ]
SUPFAMi SSF56762. SSF56762. 1 hit.
TIGRFAMsi TIGR01962. NuoD. 1 hit.
PROSITEi PS00535. COMPLEX1_49K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete mitochondrial DNA sequences of Nephroselmis olivacea and Pedinomonas minor: two radically different evolutionary patterns within the green algae."
    Turmel M., Lemieux C., Burger G., Lang B.F., Otis C., Plante I., Gray M.W.
    Plant Cell 11:1717-1730(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NIES-484.

Entry informationi

Entry nameiNDUS2_NEPOL
AccessioniPrimary (citable) accession number: Q9TC96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3