ID   NDUS2_CAFRO             Reviewed;         398 AA.
AC   Q9TAJ7;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   16-JUN-2009, entry version 51.
DE   RecName: Full=NADH-ubiquinone oxidoreductase 49 kDa subunit;
DE            EC=1.6.5.3;
DE            EC=1.6.99.3;
DE   AltName: Full=NADH dehydrogenase subunit 7;
GN   Name=NAD7;
OS   Cafeteria roenbergensis.
OG   Mitochondrion.
OC   Eukaryota; stramenopiles; Bicosoecida; Cafeteriaceae; Cafeteria.
OX   NCBI_TaxID=33653;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Burger G.;
RT   "The mitochondrial genome of Cafeteria roenbergensis.";
RL   Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I) that is believed to belong to
CC       the minimal assembly required for catalysis. Complex I functions
CC       in the transfer of electrons from NADH to the respiratory chain.
CC       The immediate electron acceptor for the enzyme is believed to be
CC       ubiquinone (By similarity). Component of the iron-sulfur (IP)
CC       fragment of the enzyme. Component of the iron-sulfur (IP) fragment
CC       of the enzyme (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADH + ubiquinone = NAD(+) + ubiquinol.
CC   -!- CATALYTIC ACTIVITY: NADH + acceptor = NAD(+) + reduced acceptor.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- SIMILARITY: Belongs to the complex I 49 kDa subunit family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AF193903; AAF05789.1; -; Genomic_DNA.
DR   RefSeq; NP_051138.1; -.
DR   GeneID; 800841; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD or NADH binding; IEA:InterPro.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:EC.
DR   GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR   GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010219; NADH_DH_1_dsu.
DR   InterPro; IPR001135; NADH_Q_OxRdtase_suD.
DR   InterPro; IPR014029; NADH_UbQ_OxRdtase_su-49kDa_CS.
DR   Pfam; PF00346; Complex1_49kDa; 1.
DR   TIGRFAMs; TIGR01962; NuoD; 1.
DR   PROSITE; PS00535; COMPLEX1_49K; 1.
PE   3: Inferred from homology;
KW   Electron transport; Mitochondrion; NAD; Oxidoreductase;
KW   Respiratory chain; Transport; Ubiquinone.
FT   CHAIN         1    398       NADH-ubiquinone oxidoreductase 49 kDa
FT                                subunit.
FT                                /FTId=PRO_0000118588.
SQ   SEQUENCE   398 AA;  45813 MW;  1BDDAF669C91404E CRC64;
     MFIKRKLKET EIKDFTLNFG PQHPAAHGVL RLILELNGET IKNADPHIGL LHRGTEKLIE
     NRNYLQALPY FDRLDYVSMM VQEHAYSLAV ERLYGINIPQ RAQWIRVLFS EITRILNHLL
     AIGCHSMDVG AMTPLLWGFE EREKLMEFYE RVSGARMHAS YIRPGGVAQD LPSGFVEDVY
     SFILDFSVRL DEIEELLTNN RIWKQRLVNV GIVTAKQAIQ NGFSGVLLRS TGIPWDLRRS
     QPYEIYDKVP FRIPVGTRGD CYDRYLIRMQ EMRQSLRIMM ACLKYLPGGS IKSDDKKFVP
     PLRWEMKNSM ESVIHHFKYF TEGFKVPAGQ TYAAVEAPKG EMGVFLISDG SNQPFRCKIK
     APGFFHLQNL PEMTKHHMIA DVVTIIGTQD IVFGEVDR
//