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Q9TAJ7 (NDUS2_CAFRO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase 49 kDa subunit

EC=1.6.5.3
EC=1.6.99.3
Alternative name(s):
NADH dehydrogenase subunit 7
Gene names
Name:NAD7
Encoded onMitochondrion
OrganismCafeteria roenbergensis
Taxonomic identifier33653 [NCBI]
Taxonomic lineageEukaryotaStramenopilesBicosoecidaCafeteriaceaeCafeteria

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme By similarity. HAMAP-Rule MF_01358

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out). HAMAP-Rule MF_01358

NADH + acceptor = NAD+ + reduced acceptor. HAMAP-Rule MF_01358

Subcellular location

Mitochondrion HAMAP-Rule MF_01358.

Sequence similarities

Belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
   Biological processElectron transport
Respiratory chain
Transport
   Cellular componentMitochondrion
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

respiratory chain

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

NADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: UniProtKB-EC

quinone binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398NADH-ubiquinone oxidoreductase 49 kDa subunit HAMAP-Rule MF_01358
PRO_0000118588

Sequences

Sequence LengthMass (Da)Tools
Q9TAJ7 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 1BDDAF669C91404E

FASTA39845,813
        10         20         30         40         50         60 
MFIKRKLKET EIKDFTLNFG PQHPAAHGVL RLILELNGET IKNADPHIGL LHRGTEKLIE 

        70         80         90        100        110        120 
NRNYLQALPY FDRLDYVSMM VQEHAYSLAV ERLYGINIPQ RAQWIRVLFS EITRILNHLL 

       130        140        150        160        170        180 
AIGCHSMDVG AMTPLLWGFE EREKLMEFYE RVSGARMHAS YIRPGGVAQD LPSGFVEDVY 

       190        200        210        220        230        240 
SFILDFSVRL DEIEELLTNN RIWKQRLVNV GIVTAKQAIQ NGFSGVLLRS TGIPWDLRRS 

       250        260        270        280        290        300 
QPYEIYDKVP FRIPVGTRGD CYDRYLIRMQ EMRQSLRIMM ACLKYLPGGS IKSDDKKFVP 

       310        320        330        340        350        360 
PLRWEMKNSM ESVIHHFKYF TEGFKVPAGQ TYAAVEAPKG EMGVFLISDG SNQPFRCKIK 

       370        380        390 
APGFFHLQNL PEMTKHHMIA DVVTIIGTQD IVFGEVDR 

« Hide

References

[1]"The mitochondrial genome of Cafeteria roenbergensis."
Burger G.
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF193903 Genomic DNA. Translation: AAF05789.1.
RefSeqNP_051138.1. NC_000946.1.

3D structure databases

ProteinModelPortalQ9TAJ7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID800841.

Family and domain databases

HAMAPMF_01358. NDH1_NuoD.
InterProIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
[Graphical view]
PfamPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
TIGRFAMsTIGR01962. NuoD. 1 hit.
PROSITEPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDUS2_CAFRO
AccessionPrimary (citable) accession number: Q9TAJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families