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Q9TAJ7

- NDUS2_CAFRO

UniProt

Q9TAJ7 - NDUS2_CAFRO

Protein

NADH-ubiquinone oxidoreductase 49 kDa subunit

Gene

NAD7

Organism
Cafeteria roenbergensis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    GO - Molecular functioni

    1. NAD binding Source: InterPro
    2. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    3. quinone binding Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase 49 kDa subunit (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    NADH dehydrogenase subunit 7
    Gene namesi
    Name:NAD7
    Encoded oniMitochondrion
    OrganismiCafeteria roenbergensis
    Taxonomic identifieri33653 [NCBI]
    Taxonomic lineageiEukaryotaStramenopilesBicosoecidaCafeteriaceaeCafeteria

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398NADH-ubiquinone oxidoreductase 49 kDa subunitPRO_0000118588Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9TAJ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 49 kDa subunit family.Curated

    Family and domain databases

    Gene3Di1.10.645.10. 2 hits.
    HAMAPiMF_01358. NDH1_NuoD.
    InterProiIPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view]
    PfamiPF00346. Complex1_49kDa. 1 hit.
    [Graphical view]
    SUPFAMiSSF56762. SSF56762. 1 hit.
    TIGRFAMsiTIGR01962. NuoD. 1 hit.
    PROSITEiPS00535. COMPLEX1_49K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9TAJ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFIKRKLKET EIKDFTLNFG PQHPAAHGVL RLILELNGET IKNADPHIGL    50
    LHRGTEKLIE NRNYLQALPY FDRLDYVSMM VQEHAYSLAV ERLYGINIPQ 100
    RAQWIRVLFS EITRILNHLL AIGCHSMDVG AMTPLLWGFE EREKLMEFYE 150
    RVSGARMHAS YIRPGGVAQD LPSGFVEDVY SFILDFSVRL DEIEELLTNN 200
    RIWKQRLVNV GIVTAKQAIQ NGFSGVLLRS TGIPWDLRRS QPYEIYDKVP 250
    FRIPVGTRGD CYDRYLIRMQ EMRQSLRIMM ACLKYLPGGS IKSDDKKFVP 300
    PLRWEMKNSM ESVIHHFKYF TEGFKVPAGQ TYAAVEAPKG EMGVFLISDG 350
    SNQPFRCKIK APGFFHLQNL PEMTKHHMIA DVVTIIGTQD IVFGEVDR 398
    Length:398
    Mass (Da):45,813
    Last modified:May 1, 2000 - v1
    Checksum:i1BDDAF669C91404E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193903 Genomic DNA. Translation: AAF05789.1.
    RefSeqiNP_051138.1. NC_000946.1.

    Genome annotation databases

    GeneIDi800841.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193903 Genomic DNA. Translation: AAF05789.1 .
    RefSeqi NP_051138.1. NC_000946.1.

    3D structure databases

    ProteinModelPortali Q9TAJ7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 800841.

    Family and domain databases

    Gene3Di 1.10.645.10. 2 hits.
    HAMAPi MF_01358. NDH1_NuoD.
    InterProi IPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR022885. NDH1_su_D/H.
    IPR029014. NiFe_Hase-like.
    [Graphical view ]
    Pfami PF00346. Complex1_49kDa. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56762. SSF56762. 1 hit.
    TIGRFAMsi TIGR01962. NuoD. 1 hit.
    PROSITEi PS00535. COMPLEX1_49K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mitochondrial genome of Cafeteria roenbergensis."
      Burger G.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiNDUS2_CAFRO
    AccessioniPrimary (citable) accession number: Q9TAJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3