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Protein

NADH-ubiquinone oxidoreductase 49 kDa subunit

Gene

NAD7

Organism
Cafeteria roenbergensis (Marine flagellate)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase 49 kDa subunit (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
NADH dehydrogenase subunit 7
Gene namesi
Name:NAD7
Encoded oniMitochondrion
OrganismiCafeteria roenbergensis (Marine flagellate)
Taxonomic identifieri33653 [NCBI]
Taxonomic lineageiEukaryotaStramenopilesBicosoecidaCafeteriaceaeCafeteria

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001185881 – 398NADH-ubiquinone oxidoreductase 49 kDa subunitAdd BLAST398

Structurei

3D structure databases

ProteinModelPortaliQ9TAJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.Curated

Family and domain databases

Gene3Di1.10.645.20, 1 hit
HAMAPiMF_01358 NDH1_NuoD, 1 hit
InterProiView protein in InterPro
IPR001135 NADH_Q_OxRdtase_suD
IPR038290 NADH_Q_OxRdtase_suD_sf
IPR014029 NADH_UbQ_OxRdtase_49kDa_CS
IPR022885 NDH1_su_D/H
IPR029014 NiFe-Hase_large
PfamiView protein in Pfam
PF00346 Complex1_49kDa, 1 hit
SUPFAMiSSF56762 SSF56762, 1 hit
TIGRFAMsiTIGR01962 NuoD, 1 hit
PROSITEiView protein in PROSITE
PS00535 COMPLEX1_49K, 1 hit

Sequencei

Sequence statusi: Complete.

Q9TAJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIKRKLKET EIKDFTLNFG PQHPAAHGVL RLILELNGET IKNADPHIGL
60 70 80 90 100
LHRGTEKLIE NRNYLQALPY FDRLDYVSMM VQEHAYSLAV ERLYGINIPQ
110 120 130 140 150
RAQWIRVLFS EITRILNHLL AIGCHSMDVG AMTPLLWGFE EREKLMEFYE
160 170 180 190 200
RVSGARMHAS YIRPGGVAQD LPSGFVEDVY SFILDFSVRL DEIEELLTNN
210 220 230 240 250
RIWKQRLVNV GIVTAKQAIQ NGFSGVLLRS TGIPWDLRRS QPYEIYDKVP
260 270 280 290 300
FRIPVGTRGD CYDRYLIRMQ EMRQSLRIMM ACLKYLPGGS IKSDDKKFVP
310 320 330 340 350
PLRWEMKNSM ESVIHHFKYF TEGFKVPAGQ TYAAVEAPKG EMGVFLISDG
360 370 380 390
SNQPFRCKIK APGFFHLQNL PEMTKHHMIA DVVTIIGTQD IVFGEVDR
Length:398
Mass (Da):45,813
Last modified:May 1, 2000 - v1
Checksum:i1BDDAF669C91404E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193903 Genomic DNA Translation: AAF05789.1
RefSeqiNP_051138.1, NC_000946.1

Genome annotation databases

GeneIDi800841

Similar proteinsi

Entry informationi

Entry nameiNDUS2_CAFRO
AccessioniPrimary (citable) accession number: Q9TAJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health