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Q9TA27

- COX1_LOXAF

UniProt

Q9TA27 - COX1_LOXAF

Protein

Cytochrome c oxidase subunit 1

Gene

MT-CO1

Organism
Loxodonta africana (African elephant)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi61 – 611Iron (heme A axial ligand)Curated
    Metal bindingi240 – 2401Copper BCurated
    Metal bindingi244 – 2441Copper BCurated
    Metal bindingi290 – 2901Copper BCurated
    Metal bindingi291 – 2911Copper BCurated
    Metal bindingi376 – 3761Iron (heme A3 axial ligand)Curated
    Metal bindingi378 – 3781Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. hydrogen ion transmembrane transport Source: GOC
    3. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:MT-CO1
    Synonyms:COI, COXI, MTCO1
    Encoded oniMitochondrion
    OrganismiLoxodonta africana (African elephant)
    Taxonomic identifieri9785 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaProboscideaElephantidaeLoxodonta
    ProteomesiUP000007646: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 515515Cytochrome c oxidase subunit 1PRO_0000232859Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9TA27.
    SMRiQ9TA27. Positions 1-511.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei183 – 20321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei310 – 33021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei338 – 35821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei380 – 40021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei414 – 43421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei456 – 47621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00390000001518.
    HOVERGENiHBG003841.
    OMAiHFGVMFT.
    OrthoDBiEOG7Q8CMW.
    TreeFamiTF353096.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9TA27-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFANRWLYST NHKDIGTLYL LFGAWAGMVG TAFSILIRAE LGQPGSLLGD    50
    DQIYNVIVTA HAFVMIFFMV MPIMIGGFGN WLIPLMIGAP DMAFPRMNNM 100
    SFWLLPPSFL LLLASSMVEA GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL 150
    HLAGVSSILS AINFITTIIN MKPPAMSQYH MPLFVWSILI TAVLLLLSLP 200
    VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG 250
    FGMVSHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD 300
    TRAYFTSATM IIAIPTGVKV FSWLATLHGG NIKWSPAMMW ALGFIFLFTI 350
    GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFIHWFPLF 400
    SGYTLNYTWA KIQFLVMFIG VNLTFFPQHF LGLSGMPRRY SDYPDAYTAW 450
    NTASSMGSFI SLVAVILMVF MIWEAFASKR EVSVMELTTT NVEWLNGCPP 500
    PHHTFEEPAY VKSNS 515
    Length:515
    Mass (Da):57,101
    Last modified:May 1, 2000 - v1
    Checksum:i938E71C66B3BC43C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ224821 Genomic DNA. Translation: CAA12140.1.
    DQ316069 Genomic DNA. Translation: ABC17906.1.
    PIRiT45552.
    RefSeqiNP_009281.1. NC_000934.1.

    Genome annotation databases

    EnsembliENSLAFT00000038050; ENSLAFP00000029493; ENSLAFG00000033284.
    GeneIDi808791.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ224821 Genomic DNA. Translation: CAA12140.1 .
    DQ316069 Genomic DNA. Translation: ABC17906.1 .
    PIRi T45552.
    RefSeqi NP_009281.1. NC_000934.1.

    3D structure databases

    ProteinModelPortali Q9TA27.
    SMRi Q9TA27. Positions 1-511.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSLAFT00000038050 ; ENSLAFP00000029493 ; ENSLAFG00000033284 .
    GeneIDi 808791.

    Organism-specific databases

    CTDi 4512.

    Phylogenomic databases

    GeneTreei ENSGT00390000001518.
    HOVERGENi HBG003841.
    OMAi HFGVMFT.
    OrthoDBi EOG7Q8CMW.
    TreeFami TF353096.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete mitochondrial genome sequence of the African elephant (Loxodonta africana), phylogenetic relationships of Proboscidea to other mammals and D-loop heteroplasmy."
      Hauf J., Waddell P.J., Chalwatzis N., Joger U., Zimmermann F.K.
      Zoology 102:184-195(2000)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Blood.
    2. "Complete mitochondrial genome and phylogeny of Pleistocene mammoth Mammuthus primigenius."
      Rogaev E.I., Moliaka Y.K., Malyarchuk B.A., Kondrashov F.A., Derenko M.V., Chumakov I., Grigorenko A.P.
      PLoS Biol. 4:403-410(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Blood.

    Entry informationi

    Entry nameiCOX1_LOXAF
    AccessioniPrimary (citable) accession number: Q9TA27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3