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Q9T1X2

- ENLYS_BPMU

UniProt

Q9T1X2 - ENLYS_BPMU

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Protein

Endolysin

Gene

lys

Organism
Enterobacteria phage Mu (Bacteriophage Mu)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity.By similarity

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton donorBy similarity
Active sitei46 – 461NucleophileBy similarity
Active sitei52 – 521By similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH24. Glycoside Hydrolase Family 24.

Names & Taxonomyi

Protein namesi
Recommended name:
Endolysin (EC:3.2.1.17)
Alternative name(s):
Gene product 22
Short name:
gp22
Lysis protein
Lysozyme
Muramidase
Gene namesi
Name:lys
Ordered Locus Names:Mup22
OrganismiEnterobacteria phage Mu (Bacteriophage Mu)
Taxonomic identifieri10677 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeMulikevirus
Virus hostiEnterobacteriaceae [TaxID: 543]
ProteomesiUP000002611: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 171171EndolysinPRO_0000218096Add
BLAST

Expressioni

Inductioni

Expressed in the intermediate phase of the viral replicative cycle.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9T1X2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 24 family.Curated

Family and domain databases

Gene3Di1.10.530.40. 1 hit.
InterProiIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamiPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9T1X2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGIPKKLKA ALLAVTIAGG GVGGYQEMTR QSLIHLENIA YMPYRDIAGV
60 70 80 90 100
LTVCVGHTGP DIEMRRYSHA ECMALLDSDL KPVYAAIDRL VRVPLTPYQK
110 120 130 140 150
TALATFIFNT GVTAFSKSTL LKKLNAGDYA GARDQMARWV FAAGHKWKGL
160 170
MNRREVEMAI WNIRGADDLR Q
Length:171
Mass (Da):18,884
Last modified:May 1, 2000 - v1
Checksum:i9F53C6ADF47D4789
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF083977 Genomic DNA. Translation: AAF01099.1.
RefSeqiNP_050626.1. NC_000929.1.

Genome annotation databases

GeneIDi2636261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF083977 Genomic DNA. Translation: AAF01099.1 .
RefSeqi NP_050626.1. NC_000929.1.

3D structure databases

ProteinModelPortali Q9T1X2.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH24. Glycoside Hydrolase Family 24.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2636261.

Family and domain databases

Gene3Di 1.10.530.40. 1 hit.
InterProi IPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view ]
Pfami PF00959. Phage_lysozyme. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Bacteriophage Mu genome sequence: analysis and comparison with Mu-like prophages in Haemophilus, Neisseria and Deinococcus."
    Morgan G.J., Hatfull G.F., Casjens S., Hendrix R.W.
    J. Mol. Biol. 317:337-359(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Localization and regulation of bacteriophage Mu promoters."
    Stoddard S.F., Howe M.M.
    J. Bacteriol. 171:3440-3448(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiENLYS_BPMU
AccessioniPrimary (citable) accession number: Q9T1X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: October 1, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3