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Q9T1X2

- ENLYS_BPMU

UniProt

Q9T1X2 - ENLYS_BPMU

Protein

Endolysin

Gene

lys

Organism
Enterobacteria phage Mu (Bacteriophage Mu)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity.By similarity

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei37 – 371Proton donorBy similarity
    Active sitei46 – 461NucleophileBy similarity
    Active sitei52 – 521By similarity

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW
    4. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH24. Glycoside Hydrolase Family 24.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endolysin (EC:3.2.1.17)
    Alternative name(s):
    Gene product 22
    Short name:
    gp22
    Lysis protein
    Lysozyme
    Muramidase
    Gene namesi
    Name:lys
    Ordered Locus Names:Mup22
    OrganismiEnterobacteria phage Mu (Bacteriophage Mu)
    Taxonomic identifieri10677 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeMulikevirus
    Virus hostiEnterobacteriaceae [TaxID: 543]
    ProteomesiUP000002611: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 171171EndolysinPRO_0000218096Add
    BLAST

    Expressioni

    Inductioni

    Expressed in the intermediate phase of the viral replicative cycle.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9T1X2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 24 family.Curated

    Family and domain databases

    Gene3Di1.10.530.40. 1 hit.
    InterProiIPR002196. Glyco_hydro_24.
    IPR023346. Lysozyme-like_dom.
    IPR023347. Lysozyme_dom.
    [Graphical view]
    PfamiPF00959. Phage_lysozyme. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9T1X2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGIPKKLKA ALLAVTIAGG GVGGYQEMTR QSLIHLENIA YMPYRDIAGV    50
    LTVCVGHTGP DIEMRRYSHA ECMALLDSDL KPVYAAIDRL VRVPLTPYQK 100
    TALATFIFNT GVTAFSKSTL LKKLNAGDYA GARDQMARWV FAAGHKWKGL 150
    MNRREVEMAI WNIRGADDLR Q 171
    Length:171
    Mass (Da):18,884
    Last modified:May 1, 2000 - v1
    Checksum:i9F53C6ADF47D4789
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083977 Genomic DNA. Translation: AAF01099.1.
    RefSeqiNP_050626.1. NC_000929.1.

    Genome annotation databases

    GeneIDi2636261.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083977 Genomic DNA. Translation: AAF01099.1 .
    RefSeqi NP_050626.1. NC_000929.1.

    3D structure databases

    ProteinModelPortali Q9T1X2.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH24. Glycoside Hydrolase Family 24.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2636261.

    Family and domain databases

    Gene3Di 1.10.530.40. 1 hit.
    InterProi IPR002196. Glyco_hydro_24.
    IPR023346. Lysozyme-like_dom.
    IPR023347. Lysozyme_dom.
    [Graphical view ]
    Pfami PF00959. Phage_lysozyme. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Bacteriophage Mu genome sequence: analysis and comparison with Mu-like prophages in Haemophilus, Neisseria and Deinococcus."
      Morgan G.J., Hatfull G.F., Casjens S., Hendrix R.W.
      J. Mol. Biol. 317:337-359(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Localization and regulation of bacteriophage Mu promoters."
      Stoddard S.F., Howe M.M.
      J. Bacteriol. 171:3440-3448(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiENLYS_BPMU
    AccessioniPrimary (citable) accession number: Q9T1X2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3