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Q9T1T5

- LYS_BPAPS

UniProt

Q9T1T5 - LYS_BPAPS

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Protein

Probable lysozyme

Gene

13

Organism
Acyrthosiphon pisum secondary endosymbiont phage 1 (Bacteriophage APSE-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity.By similarity

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei15 – 151Proton donorBy similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH24. Glycoside Hydrolase Family 24.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lysozyme (EC:3.2.1.17)
Alternative name(s):
Endolysin
Lysis protein
Muramidase
P13
Gene namesi
Name:13
OrganismiAcyrthosiphon pisum secondary endosymbiont phage 1 (Bacteriophage APSE-1)
Taxonomic identifieri67571 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridae
Virus hostiEscherichia coli [TaxID: 562]
ProteomesiUP000000853: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 146146Probable lysozymePRO_0000218091Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9T1T5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 24 family.Curated

Family and domain databases

Gene3Di1.10.530.40. 1 hit.
InterProiIPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view]
PfamiPF00959. Phage_lysozyme. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9T1T5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHISEKGLVL IKRYEGLRLK AYQCRAGRWT LGYGHTHNLN IGDVITQEQA
60 70 80 90 100
EAFLREDIAQ VTALLNTQIK VPLTQNQYDA ICSLVFNIGM TAFTTSTLLK
110 120 130 140
KLNVGDYSGA SAEFMKWSKA KVNGKRTPLP GLIKRRQAEK ALFESA
Length:146
Mass (Da):16,330
Last modified:May 1, 2000 - v1
Checksum:iAF9689BC02218086
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF157835 Genomic DNA. Translation: AAF03956.1.
RefSeqiNP_050974.1. NC_000935.1.

Genome annotation databases

GeneIDi1262307.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF157835 Genomic DNA. Translation: AAF03956.1 .
RefSeqi NP_050974.1. NC_000935.1.

3D structure databases

ProteinModelPortali Q9T1T5.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH24. Glycoside Hydrolase Family 24.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1262307.

Family and domain databases

Gene3Di 1.10.530.40. 1 hit.
InterProi IPR002196. Glyco_hydro_24.
IPR023346. Lysozyme-like_dom.
IPR023347. Lysozyme_dom.
[Graphical view ]
Pfami PF00959. Phage_lysozyme. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of APSE-1, a bacteriophage infecting the secondary endosymbiont of acyrthosiphon pisum."
    van der Wilk F., Dullemans A.M., Verbeek M., van den Heuvel J.F.J.M.
    Virology 262:104-113(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiLYS_BPAPS
AccessioniPrimary (citable) accession number: Q9T1T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: October 1, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3