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Q9T1T5

- LYS_BPAPS

UniProt

Q9T1T5 - LYS_BPAPS

Protein

Probable lysozyme

Gene

13

Organism
Acyrthosiphon pisum secondary endosymbiont phage 1 (Bacteriophage APSE-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity.By similarity

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei15 – 151Proton donorBy similarity

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro
    2. cytolysis Source: UniProtKB-KW
    3. defense response to bacterium Source: UniProtKB-KW
    4. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH24. Glycoside Hydrolase Family 24.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable lysozyme (EC:3.2.1.17)
    Alternative name(s):
    Endolysin
    Lysis protein
    Muramidase
    P13
    Gene namesi
    Name:13
    OrganismiAcyrthosiphon pisum secondary endosymbiont phage 1 (Bacteriophage APSE-1)
    Taxonomic identifieri67571 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridae
    Virus hostiEscherichia coli [TaxID: 562]
    ProteomesiUP000000853: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 146146Probable lysozymePRO_0000218091Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9T1T5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 24 family.Curated

    Family and domain databases

    Gene3Di1.10.530.40. 1 hit.
    InterProiIPR002196. Glyco_hydro_24.
    IPR023346. Lysozyme-like_dom.
    IPR023347. Lysozyme_dom.
    [Graphical view]
    PfamiPF00959. Phage_lysozyme. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9T1T5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHISEKGLVL IKRYEGLRLK AYQCRAGRWT LGYGHTHNLN IGDVITQEQA    50
    EAFLREDIAQ VTALLNTQIK VPLTQNQYDA ICSLVFNIGM TAFTTSTLLK 100
    KLNVGDYSGA SAEFMKWSKA KVNGKRTPLP GLIKRRQAEK ALFESA 146
    Length:146
    Mass (Da):16,330
    Last modified:May 1, 2000 - v1
    Checksum:iAF9689BC02218086
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF157835 Genomic DNA. Translation: AAF03956.1.
    RefSeqiNP_050974.1. NC_000935.1.

    Genome annotation databases

    GeneIDi1262307.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF157835 Genomic DNA. Translation: AAF03956.1 .
    RefSeqi NP_050974.1. NC_000935.1.

    3D structure databases

    ProteinModelPortali Q9T1T5.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH24. Glycoside Hydrolase Family 24.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1262307.

    Family and domain databases

    Gene3Di 1.10.530.40. 1 hit.
    InterProi IPR002196. Glyco_hydro_24.
    IPR023346. Lysozyme-like_dom.
    IPR023347. Lysozyme_dom.
    [Graphical view ]
    Pfami PF00959. Phage_lysozyme. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of APSE-1, a bacteriophage infecting the secondary endosymbiont of acyrthosiphon pisum."
      van der Wilk F., Dullemans A.M., Verbeek M., van den Heuvel J.F.J.M.
      Virology 262:104-113(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiLYS_BPAPS
    AccessioniPrimary (citable) accession number: Q9T1T5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3