Q9T1T5 (LYS_BPAPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable lysozyme
EC=3.2.1.17

Alternative name(s):
Endolysin
Lysis protein
Muramidase
P13

Gene names

Name:

13

Organism

Acyrthosiphon pisum secondary endosymbiont phage 1 (Bacteriophage APSE-1) [Complete proteome]

Taxonomic identifier

67571 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Caudovirales › Podoviridae › unassigned Podoviridae

Virus host

Escherichia coli [TaxID: 562]

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity By similarity.
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Sequence similarities	Belongs to the glycosyl hydrolase 24 family.

Ontologies

Keywords
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 146	146	Probable lysozyme		PRO_0000218091
Sites
	Active site	15	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9T1T5 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: AF9689BC02218086	FASTA	146	16,330
	10 20 30 40 50 60 MHISEKGLVL IKRYEGLRLK AYQCRAGRWT LGYGHTHNLN IGDVITQEQA EAFLREDIAQ 70 80 90 100 110 120 VTALLNTQIK VPLTQNQYDA ICSLVFNIGM TAFTTSTLLK KLNVGDYSGA SAEFMKWSKA 130 140 KVNGKRTPLP GLIKRRQAEK ALFESA

References

[1]

"Isolation and characterization of APSE-1, a bacteriophage infecting the secondary endosymbiont of acyrthosiphon pisum." van der Wilk F., Dullemans A.M., Verbeek M., van den Heuvel J.F.J.M. Virology 262:104-113(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF157835 Genomic DNA. Translation: AAF03956.1.
RefSeq	NP_050974.1. NC_000935.1.
3D structure databases
ProteinModelPortal	Q9T1T5.
ModBase	Search...
Protein family/group databases
CAZy	GH24. Glycoside Hydrolase Family 24.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1262307.
Phylogenomic databases
ProtClustDB	CLSP2743404.
Family and domain databases
Gene3D	1.10.530.40. 1 hit.
InterPro	IPR002196. Glyco_hydro_24. IPR023346. Lysozyme-like_dom. IPR023347. Lysozyme_dom. [Graphical view]
Pfam	PF00959. Phage_lysozyme. 1 hit. [Graphical view]
SUPFAM	SSF53955. SSF53955. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LYS_BPAPS

Accession

Primary (citable) accession number: Q9T1T5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program