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Q9T0M8 (PROF2_PARJU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Profilin-2
Alternative name(s):
Pollen allergen Par j 3.0102
Allergen=Par j 3.0102
Gene names
Name:PRO2
OrganismParietaria judaica (Pellitory-of-the-wall) (Parietaria diffusa)
Taxonomic identifier33127 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesUrticaceaeParietaria

Protein attributes

Sequence length131 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.

Subunit structure

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Subcellular location

Cytoplasmcytoskeleton By similarity.

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Belongs to the profilin family.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   DiseaseAllergen
   LigandActin-binding
Gene Ontology (GO)
   Biological_processactin cytoskeleton organization

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 131130Profilin-2
PRO_0000199662

Sequences

Sequence LengthMass (Da)Tools
Q9T0M8 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 8A4FCC0BAC1565AB

FASTA13113,784
        10         20         30         40         50         60 
MSWQAYVDDH LMCDVGDGNT LASAAIIGHD GSVWAQSANF PQLKPEEVTG IMNDFNEGGF 

        70         80         90        100        110        120 
LAPTGLFLGG TKYMVIQGES GAVIGKKGSG GATLKKTGQA IVIGIYDEPM TPGQCNLVVE 

       130 
RLGDYLLEQG M 

« Hide

References

[1]"Analysis of recombinant allergen Par j 3 (profilin) from Parietaria judaica."
Asturias J.A., Arilla M.C., Gomez-Bayon N., Martinez A., Martinez J., Palacios R.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pollen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y15209 mRNA. Translation: CAB44257.1.

3D structure databases

ProteinModelPortalQ9T0M8.
SMRQ9T0M8. Positions 2-131.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome510. Par j 3.
512. Par j 3.0102.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR027310. Profilin_CS.
IPR005455. Profilin_eukaryotes/bac.
[Graphical view]
PANTHERPTHR11604. PTHR11604. 1 hit.
PfamPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMSSF55770. SSF55770. 1 hit.
PROSITEPS00414. PROFILIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePROF2_PARJU
AccessionPrimary (citable) accession number: Q9T0M8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries