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Q9T0M8

- PROF2_PARJU

UniProt

Q9T0M8 - PROF2_PARJU

Protein

Profilin-2

Gene

PRO2

Organism
Parietaria judaica (Pellitory-of-the-wall) (Parietaria diffusa)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.By similarity

    GO - Biological processi

    1. actin cytoskeleton organization Source: InterPro

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Profilin-2
    Alternative name(s):
    Pollen allergen Par j 3.0102
    Allergen: Par j 3.0102
    Gene namesi
    Name:PRO2
    OrganismiParietaria judaica (Pellitory-of-the-wall) (Parietaria diffusa)
    Taxonomic identifieri33127 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesUrticaceaeParietaria

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei510. Par j 3.
    512. Par j 3.0102.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 131130Profilin-2PRO_0000199662Add
    BLAST

    Interactioni

    Subunit structurei

    Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9T0M8.
    SMRiQ9T0M8. Positions 2-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the profilin family.Curated

    Family and domain databases

    InterProiIPR027310. Profilin_CS.
    IPR005455. Profilin_eukaryotes/bac.
    [Graphical view]
    PANTHERiPTHR11604. PTHR11604. 1 hit.
    PfamiPF00235. Profilin. 1 hit.
    [Graphical view]
    PRINTSiPR00392. PROFILIN.
    PR01640. PROFILINPLNT.
    SMARTiSM00392. PROF. 1 hit.
    [Graphical view]
    SUPFAMiSSF55770. SSF55770. 1 hit.
    PROSITEiPS00414. PROFILIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9T0M8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWQAYVDDH LMCDVGDGNT LASAAIIGHD GSVWAQSANF PQLKPEEVTG    50
    IMNDFNEGGF LAPTGLFLGG TKYMVIQGES GAVIGKKGSG GATLKKTGQA 100
    IVIGIYDEPM TPGQCNLVVE RLGDYLLEQG M 131
    Length:131
    Mass (Da):13,784
    Last modified:May 1, 2000 - v1
    Checksum:i8A4FCC0BAC1565AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y15209 mRNA. Translation: CAB44257.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y15209 mRNA. Translation: CAB44257.1 .

    3D structure databases

    ProteinModelPortali Q9T0M8.
    SMRi Q9T0M8. Positions 2-131.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 510. Par j 3.
    512. Par j 3.0102.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR027310. Profilin_CS.
    IPR005455. Profilin_eukaryotes/bac.
    [Graphical view ]
    PANTHERi PTHR11604. PTHR11604. 1 hit.
    Pfami PF00235. Profilin. 1 hit.
    [Graphical view ]
    PRINTSi PR00392. PROFILIN.
    PR01640. PROFILINPLNT.
    SMARTi SM00392. PROF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55770. SSF55770. 1 hit.
    PROSITEi PS00414. PROFILIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of recombinant allergen Par j 3 (profilin) from Parietaria judaica."
      Asturias J.A., Arilla M.C., Gomez-Bayon N., Martinez A., Martinez J., Palacios R.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pollen.

    Entry informationi

    Entry nameiPROF2_PARJU
    AccessioniPrimary (citable) accession number: Q9T0M8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3