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Q9T0M8

- PROF2_PARJU

UniProt

Q9T0M8 - PROF2_PARJU

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Protein

Profilin-2

Gene

PRO2

Organism
Parietaria judaica (Pellitory-of-the-wall) (Parietaria diffusa)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.By similarity

GO - Biological processi

  1. actin cytoskeleton organization Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-2
Alternative name(s):
Pollen allergen Par j 3.0102
Allergen: Par j 3.0102
Gene namesi
Name:PRO2
OrganismiParietaria judaica (Pellitory-of-the-wall) (Parietaria diffusa)
Taxonomic identifieri33127 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesUrticaceaeParietaria

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei510. Par j 3.
512. Par j 3.0102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 131130Profilin-2PRO_0000199662Add
BLAST

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Structurei

3D structure databases

ProteinModelPortaliQ9T0M8.
SMRiQ9T0M8. Positions 2-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Family and domain databases

InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9T0M8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWQAYVDDH LMCDVGDGNT LASAAIIGHD GSVWAQSANF PQLKPEEVTG
60 70 80 90 100
IMNDFNEGGF LAPTGLFLGG TKYMVIQGES GAVIGKKGSG GATLKKTGQA
110 120 130
IVIGIYDEPM TPGQCNLVVE RLGDYLLEQG M
Length:131
Mass (Da):13,784
Last modified:May 1, 2000 - v1
Checksum:i8A4FCC0BAC1565AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y15209 mRNA. Translation: CAB44257.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y15209 mRNA. Translation: CAB44257.1 .

3D structure databases

ProteinModelPortali Q9T0M8.
SMRi Q9T0M8. Positions 2-131.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 510. Par j 3.
512. Par j 3.0102.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view ]
PANTHERi PTHR11604. PTHR11604. 1 hit.
Pfami PF00235. Profilin. 1 hit.
[Graphical view ]
PRINTSi PR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTi SM00392. PROF. 1 hit.
[Graphical view ]
SUPFAMi SSF55770. SSF55770. 1 hit.
PROSITEi PS00414. PROFILIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of recombinant allergen Par j 3 (profilin) from Parietaria judaica."
    Asturias J.A., Arilla M.C., Gomez-Bayon N., Martinez A., Martinez J., Palacios R.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pollen.

Entry informationi

Entry nameiPROF2_PARJU
AccessioniPrimary (citable) accession number: Q9T0M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3