Q9T0G7 (SUVH9_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH9
EC=2.1.1.43

Alternative name(s):
Histone H3-K9 methyltransferase 9
Short name=H3-K9-HMTase 9
Protein SET DOMAIN GROUP 22
Suppressor of variegation 3-9 homolog protein 9
Short name=Su(var)3-9 homolog protein 9

Gene names

Name:	SUVH9
Synonyms:	SDG22, SET22
Ordered Locus Names:	At4g13460
ORF Names:	T6G15.10

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	650 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subcellular location	Nucleus By similarity. Chromosome › centromere By similarity. Note: Associates with centromeric constitutive heterochromatin By similarity.
Domain	Although both SET and pre-SET domains are present, the absence of the post-SET domain may alter the methyltransferase activity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. Contains 1 pre-SET domain. Contains 1 SET domain. Contains 1 YDG domain.

Ontologies

Keywords
Cellular component	Centromere Chromosome Nucleus
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA mediated transformation Inferred from mutant phenotype PubMed 17827277. Source: TAIR
Cellular_component	chromosome, centromeric region Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 650	650	Probable histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH9		PRO_0000186080
Regions
	Domain	205 – 352	148	YDG
	Domain	432 – 490	59	Pre-SET
	Domain	492 – 641	150	SET

Sequences

	Sequence		Length	Mass (Da)
	Q9T0G7 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: B2F291C5FA18A6E9	FASTA	650	72,174
	10 20 30 40 50 60 MGSSHIPLDP SLNPSPSLIP KLEPVTESTQ NLAFQLPNTN PQALISSAVS DFNEATDFSS 70 80 90 100 110 120 DYNTVAESAR SAFAQRLQRH DDVAVLDSLT GAIVPVEENP EPEPNPYSTS DSSPSVATQR 130 140 150 160 170 180 PRPQPRSSEL VRITDVGPES ERQFREHVRK TRMIYDSLRM FLMMEEAKRN GVGGRRARAD 190 200 210 220 230 240 GKAGKAGSMM RDCMLWMNRD KRIVGSIPGV QVGDIFFFRF ELCVMGLHGH PQSGIDFLTG 250 260 270 280 290 300 SLSSNGEPIA TSVIVSGGYE DDDDQGDVIM YTGQGGQDRL GRQAEHQRLE GGNLAMERSM 310 320 330 340 350 360 YYGIEVRVIR GLKYENEVSS RVYVYDGLFR IVDSWFDVGK SGFGVFKYRL ERIEGQAEMG 370 380 390 400 410 420 SSVLKFARTL KTNPLSVRPR GYINFDISNG KENVPVYLFN DIDSDQEPLY YEYLAQTSFP 430 440 450 460 470 480 PGLFVQQSGN ASGCDCVNGC GSGCLCEAKN SGEIAYDYNG TLIRQKPLIH ECGSACQCPP 490 500 510 520 530 540 SCRNRVTQKG LRNRLEVFRS LETGWGVRSL DVLHAGAFIC EYAGVALTRE QANILTMNGD 550 560 570 580 590 600 TLVYPARFSS ARWEDWGDLS QVLADFERPS YPDIPPVDFA MDVSKMRNVA CYISHSTDPN 610 620 630 640 650 VIVQFVLHDH NSLMFPRVML FAAENIPPMT ELSLDYGVVD DWNAKLAICN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes." Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B. Nucleic Acids Res. 29:4319-4333(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], NOMENCLATURE.
[2]	"Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana." Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B. , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R. Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[4]	"Heterochromatin proteins and the control of heterochromatic gene silencing in Arabidopsis." Fischer A., Hofmann I., Naumann K., Reuter G. J. Plant Physiol. 163:358-368(2006) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF344452 mRNA. Translation: AAK28974.1. AL049656 Genomic DNA. Translation: CAB41104.1. AL161536 Genomic DNA. Translation: CAB78388.1. CP002687 Genomic DNA. Translation: AEE83282.1. CP002687 Genomic DNA. Translation: AEE83283.1.
IPI	IPI00529277.
PIR	T06648.
RefSeq	NP_001031625.1. NM_001036548.1. NP_193082.1. NM_117420.2.
UniGene	At.3118.
3D structure databases
ProteinModelPortal	Q9T0G7.
SMR	Q9T0G7. Positions 202-359, 383-637.
ModBase	Search...
Proteomic databases
PaxDb	Q9T0G7.
PRIDE	Q9T0G7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT4G13460.1; AT4G13460.1; AT4G13460. AT4G13460.2; AT4G13460.2; AT4G13460.
GeneID	826978.
KEGG	ath:AT4G13460.
Organism-specific databases
TAIR	At4g13460.
Phylogenomic databases
eggNOG	COG3440.
HOGENOM	HOG000238382.
InParanoid	Q9T0G7.
KO	K11420.
OMA	EGQAEMG.
PhylomeDB	Q9T0G7.
ProtClustDB	CLSN2685938.
Gene expression databases
ArrayExpress	Q9T0G7.
Genevestigator	Q9T0G7.
GermOnline	AT4G13460. Arabidopsis thaliana.
Family and domain databases
Gene3D	2.30.280.10. 1 hit.
InterPro	IPR025794. Hist-Lys_N-MeTrfase_plant. IPR007728. Pre-SET_dom. IPR003606. Pre-SET_Zn-bd_sub. IPR001214. SET_dom. IPR003105. SRA_YDG. [Graphical view]
Pfam	PF05033. Pre-SET. 1 hit. PF00856. SET. 1 hit. PF02182. YDG_SRA. 1 hit. [Graphical view]
SMART	SM00468. PreSET. 1 hit. SM00317. SET. 1 hit. SM00466. SRA. 1 hit. [Graphical view]
PROSITE	PS50867. PRE_SET. 1 hit. PS50280. SET. 1 hit. PS51015. YDG. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUVH9_ARATH

Accession

Primary (citable) accession number: Q9T0G7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 9, 2003
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program