Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Long chain acyl-CoA synthetase 4

Gene

LACS4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate and linoleate.

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.1 Publication

Cofactori

Mg2+By similarity

Pathwayi: fatty acid metabolism

This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi228 – 239ATPSequence analysisAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • fatty acid metabolic process Source: UniProtKB

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT4G23850-MONOMER
MetaCyc:AT4G23850-MONOMER
SABIO-RKiQ9T0A0
UniPathwayiUPA00199

Names & Taxonomyi

Protein namesi
Recommended name:
Long chain acyl-CoA synthetase 4 (EC:6.2.1.3)
Gene namesi
Name:LACS4
Ordered Locus Names:At4g23850
ORF Names:T32A16_20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G23850
TAIRilocus:2138141 AT4G23850

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004014121 – 666Long chain acyl-CoA synthetase 4Add BLAST666

Proteomic databases

PaxDbiQ9T0A0
PRIDEiQ9T0A0

PTM databases

iPTMnetiQ9T0A0

Expressioni

Gene expression databases

ExpressionAtlasiQ9T0A0 baseline and differential
GenevisibleiQ9T0A0 AT

Interactioni

Protein-protein interaction databases

BioGridi13773, 2 interactors
STRINGi3702.AT4G23850.1

Structurei

3D structure databases

ProteinModelPortaliQ9T0A0
SMRiQ9T0A0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni495 – 519Fatty acid-bindingSequence analysisAdd BLAST25

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1256 Eukaryota
COG1022 LUCA
HOGENOMiHOG000159459
InParanoidiQ9T0A0
KOiK01897
OMAiGHSHTGD
OrthoDBiEOG093604GF
PhylomeDBiQ9T0A0

Family and domain databases

InterProiView protein in InterPro
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q9T0A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQQKKYIFQ VEEGKEGSDG RPSVGPVYRS IFAKDGFPDP IEGMDSCWDV
60 70 80 90 100
FRMSVEKYPN NPMLGRREIV DGKPGKYVWQ TYQEVYDIVM KLGNSLRSVG
110 120 130 140 150
VKDEAKCGIY GANSPEWIIS MEACNAHGLY CVPLYDTLGA DAVEFIISHS
160 170 180 190 200
EVSIVFVEEK KISELFKTCP NSTEYMKTVV SFGGVSREQK EEAETFGLVI
210 220 230 240 250
YAWDEFLKLG EGKQYDLPIK KKSDICTIMY TSGTTGDPKG VMISNESIVT
260 270 280 290 300
LIAGVIRLLK SANEALTVKD VYLSYLPLAH IFDRVIEECF IQHGAAIGFW
310 320 330 340 350
RGDVKLLIED LAELKPTIFC AVPRVLDRVY SGLQKKLSDG GFLKKFIFDS
360 370 380 390 400
AFSYKFGYMK KGQSHVEASP LFDKLVFSKV KQGLGGNVRI ILSGAAPLAS
410 420 430 440 450
HVESFLRVVA CCHVLQGYGL TESCAGTFVS LPDELGMLGT VGPPVPNVDI
460 470 480 490 500
RLESVPEMEY DALASTARGE ICIRGKTLFS GYYKREDLTK EVLIDGWLHT
510 520 530 540 550
GDVGEWQPDG SMKIIDRKKN IFKLSQGEYV AVENIENIYG EVQAVDSVWV
560 570 580 590 600
YGNSFESFLI AIANPNQHIL ERWAAENGVS GDYDALCQNE KAKEFILGEL
610 620 630 640 650
VKMAKEKKMK GFEIIKAIHL DPVPFDMERD LLTPTFKKKR PQLLKYYQSV
660
IDEMYKTINA KFASRG
Length:666
Mass (Da):74,508
Last modified:May 1, 2000 - v1
Checksum:i8E663756D60B0E57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503754 mRNA Translation: AAM28871.1
AL078468 Genomic DNA Translation: CAB43885.1
AL161560 Genomic DNA Translation: CAB81303.1
CP002687 Genomic DNA Translation: AEE84812.1
AY049239 mRNA Translation: AAK83581.1
PIRiT08904
RefSeqiNP_194116.1, NM_118516.5
UniGeneiAt.3384

Genome annotation databases

EnsemblPlantsiAT4G23850.1; AT4G23850.1; AT4G23850
GeneIDi828484
GrameneiAT4G23850.1; AT4G23850.1; AT4G23850
KEGGiath:AT4G23850

Similar proteinsi

Entry informationi

Entry nameiLACS4_ARATH
AccessioniPrimary (citable) accession number: Q9T0A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health