Q9T071 (HXKL2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable hexokinase-like 2 protein
EC=2.7.1.1

Gene names

Ordered Locus Names:	At4g37840
ORF Names:	T28I19.120

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + D-hexose = ADP + D-hexose 6-phosphate.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the hexokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW response to DNA damage stimulus Inferred from expression pattern. Source: TAIR response to UV-B Inferred from expression pattern. Source: TAIR response to cold Inferred from expression pattern. Source: TAIR response to heat Inferred from expression pattern. Source: TAIR response to oxidative stress Inferred from expression pattern. Source: TAIR response to salt stress Inferred from expression pattern. Source: TAIR response to water deprivation Inferred from expression pattern. Source: TAIR
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrion Inferred from direct assay. Source: TAIR
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hexokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Probable hexokinase-like 2 protein		PRO_0000197614
Regions
	Transmembrane	5 – 25	21	Helical; Potential
	Nucleotide binding	102 – 107	6	ATP Potential
	Region	169 – 195	27	Glucose-binding Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9T071 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: D8AC1DEE716996C8	FASTA	493	54,241
	10 20 30 40 50 60 MTRKEVVLAV TAATITAVAA GVLMGRWIRR KERRLKHTQR ILRKFARECA TPVSKLWAVA 70 80 90 100 110 120 DALVADMTAS LTAECCGSLN MLVSFTGSLP SGDEKGVHYG VNLRGKELLL LRGTLGGNEE 130 140 150 160 170 180 PISDVQKHEI PIPDDVLNGS FKELCDFISL ELVKFLAMNP GGEAEEVKNL GFTLTRSVEQ 190 200 210 220 230 240 IGSHSISSIH RKSLANDDDE KVLKDLVNDM NESLETHGLK IRMNTALVDN TIGELAGGRY 250 260 270 280 290 300 YHKDTVAAVS LGMGTNAAYI EQAQEISRWK SAIREPQEIV VSTEWGDFRS CHLPITEFDA 310 320 330 340 350 360 SLDAESLNPG HRIFEKMVSG RYLGEIVRRV LLKMSEESAL FGDTLPPKLT IPYILWSPDM 370 380 390 400 410 420 AAMHQDISEE RETVNKKLKE VFGIMDSTLA AREVVVEVCD VVAERAARLA GAGIVGMIKK 430 440 450 460 470 480 LGRLEKKMSI VIVEGGLYDH YRVFRNYLHS SVWEMLGDEL SDHVVIEHSH GGSAAGALFL 490 AACGDGHQDS ESK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana." Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B. , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R. Nature 402:769-777(1999) [PubMed: 10617198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL035709 Genomic DNA. Translation: CAB38932.1. AL161592 Genomic DNA. Translation: CAB80449.1. CP002687 Genomic DNA. Translation: AEE86844.1.
IPI	IPI00525088.
PIR	T06031.
RefSeq	NP_195497.1. NM_119945.1.
UniGene	At.54644.
3D structure databases
ProteinModelPortal	Q9T071.
SMR	Q9T071. Positions 8-489.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9T071.
Proteomic databases
PRIDE	Q9T071.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT4G37840.1; AT4G37840.1; AT4G37840.
GeneID	829940.
GenomeReviews	Gene locus AT4G37840 in contig CT486007_GR.
KEGG	ath:AT4G37840.
NMPDR	fig|3702.1.peg.21896.
Organism-specific databases
TAIR	At4g37840.
Phylogenomic databases
eggNOG	KOG1369.
GeneTree	EPGT00050000013968.
HOGENOM	HBG522186.
InParanoid	Q9T071.
OMA	VIEHSHG.
PhylomeDB	Q9T071.
ProtClustDB	PLN02596.
Gene expression databases
ArrayExpress	Q9T071.
Genevestigator	Q9T071.
GermOnline	AT4G37840. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR022673. Hexokinase_C. IPR022672. Hexokinase_N. [Graphical view]
KO	K00844.
PANTHER	PTHR19443. Hexokinase. 1 hit.
Pfam	PF00349. Hexokinase_1. 1 hit. PF03727. Hexokinase_2. 1 hit. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
ProtoNet	Search...

Entry information

Entry name

HXKL2_ARATH

Accession

Primary (citable) accession number: Q9T071

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	November 16, 2011
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program