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Protein

Long chain acyl-CoA synthetase 5

Gene

LACS5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate and linoleate.

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.1 Publication

Cofactori

Mg2+By similarity

Pathwayi: fatty acid metabolism

This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi228 – 239ATPSequence analysisAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • fatty acid metabolic process Source: UniProtKB

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT4G11030-MONOMER
MetaCyc:AT4G11030-MONOMER
UniPathwayiUPA00199

Names & Taxonomyi

Protein namesi
Recommended name:
Long chain acyl-CoA synthetase 5 (EC:6.2.1.3)
Gene namesi
Name:LACS5
Ordered Locus Names:At4g11030
ORF Names:F8M12.15, T22B4.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G11030
TAIRilocus:2136148 AT4G11030

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004014131 – 666Long chain acyl-CoA synthetase 5Add BLAST666

Proteomic databases

PaxDbiQ9T009

Expressioni

Gene expression databases

ExpressionAtlasiQ9T009 baseline and differential
GenevisibleiQ9T009 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G11030.1

Structurei

3D structure databases

ProteinModelPortaliQ9T009
SMRiQ9T009
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni495 – 519Fatty acid-bindingSequence analysisAdd BLAST25

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1256 Eukaryota
COG1022 LUCA
HOGENOMiHOG000159459
InParanoidiQ9T009
KOiK01897
OMAiAFTVEND
OrthoDBiEOG093604GF
PhylomeDBiQ9T009

Family and domain databases

InterProiView protein in InterPro
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q9T009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSQKRFIFE VEAAKEATDG NPSVGPVYRS TFAQNGFPNP IDGIQSCWDI
60 70 80 90 100
FRTAVEKYPN NRMLGRREIS NGKAGKYVWK TYKEVYDIVI KLGNSLRSCG
110 120 130 140 150
IKEGEKCGIY GINCCEWIIS MEACNAHGLY CVPLYDTLGA GAVEFIISHA
160 170 180 190 200
EVSIAFVEEK KIPELFKTCP NSTKYMKTVV SFGGVKPEQK EEAEKLGLVI
210 220 230 240 250
HSWDEFLKLG EGKQYELPIK KPSDICTIMY TSGTTGDPKG VMISNESIVT
260 270 280 290 300
ITTGVMHFLG NVNASLSEKD VYISYLPLAH VFDRAIEECI IQVGGSIGFW
310 320 330 340 350
RGDVKLLIED LGELKPSIFC AVPRVLDRVY TGLQQKLSGG GFFKKKVFDV
360 370 380 390 400
AFSYKFGNMK KGQSHVAASP FCDKLVFNKV KQGLGGNVRI ILSGAAPLAS
410 420 430 440 450
HIESFLRVVA CCNVLQGYGL TESCAGTFAT FPDELDMLGT VGPPVPNVDI
460 470 480 490 500
RLESVPEMNY DALGSTPRGE ICIRGKTLFS GYYKREDLTK EVFIDGWLHT
510 520 530 540 550
GDVGEWQPNG SMKIIDRKKN IFKLAQGEYV AVENLENVYS QVEVIESIWV
560 570 580 590 600
YGNSFESFLV AIANPAQQTL ERWAVENGVN GDFNSICQNA KAKAFILGEL
610 620 630 640 650
VKTAKENKLK GFEIIKDVHL EPVAFDMERD LLTPTYKKKR PQLLKYYQNV
660
IHEMYKTTKE SLASGQ
Length:666
Mass (Da):74,064
Last modified:May 1, 2000 - v1
Checksum:i6928569968215C90
GO

Sequence cautioni

The sequence AAC33962 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti661S → T in AAM28872 (PubMed:12177484).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503755 mRNA Translation: AAM28872.1
AF080118 Genomic DNA Translation: AAC33962.1 Sequence problems.
AL049876 Genomic DNA Translation: CAB43038.1
AL161518 Genomic DNA Translation: CAB81204.1
CP002687 Genomic DNA Translation: AEE82963.1
BT046194 mRNA Translation: ACI49793.1
PIRiT01875
T04298
T08182
RefSeqiNP_192841.1, NM_117173.2
UniGeneiAt.33591

Genome annotation databases

EnsemblPlantsiAT4G11030.1; AT4G11030.1; AT4G11030
GeneIDi826704
GrameneiAT4G11030.1; AT4G11030.1; AT4G11030
KEGGiath:AT4G11030

Similar proteinsi

Entry informationi

Entry nameiLACS5_ARATH
AccessioniPrimary (citable) accession number: Q9T009
Secondary accession number(s): O81614, Q8LKS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health