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Protein

Calcium-transporting ATPase 10, plasma membrane-type

Gene

ACA10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the endoplasmic reticulum.By similarity

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Enzyme regulationi

Activated by calmodulin.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4824-aspartylphosphate intermediateBy similarity1
Metal bindingi789MagnesiumBy similarity1
Metal bindingi793MagnesiumBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calcium-transporting ATPase activity Source: TAIR
  • metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT4G29900-MONOMER.
ReactomeiR-ATH-418359. Reduction of cytosolic Ca++ levels.
R-ATH-5578775. Ion homeostasis.
R-ATH-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase 10, plasma membrane-type (EC:3.6.3.8)
Alternative name(s):
Ca(2+)-ATPase isoform 10
Gene namesi
Name:ACA10
Ordered Locus Names:At4g29900
ORF Names:F27B13.140
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G29900.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 180CytoplasmicSequence analysisAdd BLAST179
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 219LumenalSequence analysisAdd BLAST18
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Topological domaini241 – 369CytoplasmicSequence analysisAdd BLAST129
Transmembranei370 – 389HelicalSequence analysisAdd BLAST20
Topological domaini390 – 426LumenalSequence analysisAdd BLAST37
Transmembranei427 – 444HelicalSequence analysisAdd BLAST18
Topological domaini445 – 844CytoplasmicSequence analysisAdd BLAST400
Transmembranei845 – 863HelicalSequence analysisAdd BLAST19
Topological domaini864 – 874LumenalSequence analysisAdd BLAST11
Transmembranei875 – 895HelicalSequence analysisAdd BLAST21
Topological domaini896 – 915CytoplasmicSequence analysisAdd BLAST20
Transmembranei916 – 938HelicalSequence analysisAdd BLAST23
Topological domaini939 – 951LumenalSequence analysisAdd BLAST13
Transmembranei952 – 973HelicalSequence analysisAdd BLAST22
Topological domaini974 – 991CytoplasmicSequence analysisAdd BLAST18
Transmembranei992 – 1013HelicalSequence analysisAdd BLAST22
Topological domaini1014 – 1023LumenalSequence analysis10
Transmembranei1024 – 1045HelicalSequence analysisAdd BLAST22
Topological domaini1046 – 1069CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • intracellular membrane-bounded organelle Source: GO_Central
  • plasma membrane Source: TAIR
  • plasmodesma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000464162 – 1069Calcium-transporting ATPase 10, plasma membrane-typeAdd BLAST1068

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9SZR1.
PRIDEiQ9SZR1.

PTM databases

iPTMnetiQ9SZR1.
SwissPalmiQ9SZR1.

Expressioni

Gene expression databases

GenevisibleiQ9SZR1. AT.

Interactioni

Protein-protein interaction databases

BioGridi14399. 1 interactor.
STRINGi3702.AT4G29900.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SZR1.
SMRiQ9SZR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni42 – 53Interaction with calmodulinBy similarityAdd BLAST12

Domaini

The N-terminus contains an autoinhibitory calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0204. Eukaryota.
ENOG410XNNC. LUCA.
HOGENOMiHOG000265623.
InParanoidiQ9SZR1.
KOiK01537.
OMAiFHITARI.
OrthoDBiEOG093601NF.
PhylomeDBiQ9SZR1.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR024750. Ca_ATPase_N_dom.
IPR023214. HAD-like_dom.
IPR006408. P-type_ATPase_IIB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF12515. CaATP_NAI. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SZR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGQFNNSPR GEDKDVEAGT SSFTEYEDSP FDIASTKNAP VERLRRWRQA
60 70 80 90 100
ALVLNASRRF RYTLDLKREE DKKQMLRKMR AHAQAIRAAH LFKAAASRVT
110 120 130 140 150
GIASPLPTPG GGDFGIGQEQ IVSISRDQNI GALQELGGVR GLSDLLKTNL
160 170 180 190 200
EKGIHGDDDD ILKRKSAFGS NTYPQKKGRS FWRFVWEASQ DLTLIILIVA
210 220 230 240 250
AVASLALGIK TEGIEKGWYD GISIAFAVLL VIVVTATSDY RQSLQFQNLN
260 270 280 290 300
EEKRNIRLEV TRDGRRVEIS IYDIVVGDVI PLNIGDQVPA DGVLVAGHSL
310 320 330 340 350
AVDESSMTGE SKIVQKNSTK HPFLMSGCKV ADGNGTMLVT GVGVNTEWGL
360 370 380 390 400
LMASVSEDNG GETPLQVRLN GVATFIGIVG LTVAGVVLFV LVVRYFTGHT
410 420 430 440 450
KNEQGGPQFI GGKTKFEHVL DDLVEIFTVA VTIVVVAVPE GLPLAVTLTL
460 470 480 490 500
AYSMRKMMAD KALVRRLSAC ETMGSATTIC SDKTGTLTLN EMTVVECYAG
510 520 530 540 550
LQKMDSPDSS SKLPSAFTSI LVEGIAHNTT GSVFRSESGE IQVSGSPTER
560 570 580 590 600
AILNWAIKLG MDFDALKSES SAVQFFPFNS EKKRGGVAVK SPDSSVHIHW
610 620 630 640 650
KGAAEIVLGS CTHYMDESES FVDMSEDKMG GLKDAIDDMA ARSLRCVAIA
660 670 680 690 700
FRTFEADKIP TDEEQLSRWE LPEDDLILLA IVGIKDPCRP GVKNSVLLCQ
710 720 730 740 750
QAGVKVRMVT GDNIQTAKAI ALECGILASD SDASEPNLIE GKVFRSYSEE
760 770 780 790 800
ERDRICEEIS VMGRSSPNDK LLLVQSLKRR GHVVAVTGDG TNDAPALHEA
810 820 830 840 850
DIGLAMGIQG TEVAKEKSDI IILDDNFESV VKVVRWGRSV YANIQKFIQF
860 870 880 890 900
QLTVNVAALV INVVAAISAG EVPLTAVQLL WVNLIMDTLG ALALATEPPT
910 920 930 940 950
DHLMDRAPVG RREPLITNIM WRNLFIQAMY QVTVLLILNF RGISILHLKS
960 970 980 990 1000
KPNAERVKNT VIFNAFVICQ VFNEFNARKP DEINIFRGVL RNHLFVGIIS
1010 1020 1030 1040 1050
ITIVLQVVIV EFLGTFASTT KLDWEMWLVC IGIGSISWPL AVIGKLIPVP
1060
ETPVSQYFRI NRWRRNSSG
Length:1,069
Mass (Da):116,858
Last modified:January 11, 2001 - v2
Checksum:i48CE4A4B218E2656
GO

Sequence cautioni

The sequence CAB43665 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050352 Genomic DNA. Translation: CAB43665.1. Sequence problems.
AL161575 Genomic DNA. Translation: CAB79748.1.
CP002687 Genomic DNA. Translation: AEE85690.1.
PIRiC85349.
T08551.
RefSeqiNP_194719.1. NM_119136.4.
UniGeneiAt.31882.
At.48920.

Genome annotation databases

EnsemblPlantsiAT4G29900.1; AT4G29900.1; AT4G29900.
GeneIDi829112.
GrameneiAT4G29900.1; AT4G29900.1; AT4G29900.
KEGGiath:AT4G29900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050352 Genomic DNA. Translation: CAB43665.1. Sequence problems.
AL161575 Genomic DNA. Translation: CAB79748.1.
CP002687 Genomic DNA. Translation: AEE85690.1.
PIRiC85349.
T08551.
RefSeqiNP_194719.1. NM_119136.4.
UniGeneiAt.31882.
At.48920.

3D structure databases

ProteinModelPortaliQ9SZR1.
SMRiQ9SZR1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi14399. 1 interactor.
STRINGi3702.AT4G29900.1.

PTM databases

iPTMnetiQ9SZR1.
SwissPalmiQ9SZR1.

Proteomic databases

PaxDbiQ9SZR1.
PRIDEiQ9SZR1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G29900.1; AT4G29900.1; AT4G29900.
GeneIDi829112.
GrameneiAT4G29900.1; AT4G29900.1; AT4G29900.
KEGGiath:AT4G29900.

Organism-specific databases

TAIRiAT4G29900.

Phylogenomic databases

eggNOGiKOG0204. Eukaryota.
ENOG410XNNC. LUCA.
HOGENOMiHOG000265623.
InParanoidiQ9SZR1.
KOiK01537.
OMAiFHITARI.
OrthoDBiEOG093601NF.
PhylomeDBiQ9SZR1.

Enzyme and pathway databases

BioCyciARA:AT4G29900-MONOMER.
ReactomeiR-ATH-418359. Reduction of cytosolic Ca++ levels.
R-ATH-5578775. Ion homeostasis.
R-ATH-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiQ9SZR1.

Gene expression databases

GenevisibleiQ9SZR1. AT.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR024750. Ca_ATPase_N_dom.
IPR023214. HAD-like_dom.
IPR006408. P-type_ATPase_IIB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF12515. CaATP_NAI. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACA10_ARATH
AccessioniPrimary (citable) accession number: Q9SZR1
Secondary accession number(s): Q9M0D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: November 30, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.