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Protein

V-type proton ATPase subunit B2

Gene

VHA-B2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciARA:AT4G38510-MONOMER
ReactomeiR-ATH-1222556 ROS, RNS production in phagocytes
R-ATH-77387 Insulin receptor recycling
R-ATH-917977 Transferrin endocytosis and recycling

Protein family/group databases

TCDBi3.A.2.2.5 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit B2
Short name:
V-ATPase subunit B2
Alternative name(s):
Vacuolar H(+)-ATPase subunit B isoform 2
Vacuolar proton pump subunit B2
Gene namesi
Name:VHA-B2
Ordered Locus Names:At4g38510
ORF Names:F20M13.70
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G38510

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003738162 – 487V-type proton ATPase subunit B2Add BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9SZN1
PRIDEiQ9SZN1

PTM databases

iPTMnetiQ9SZN1

Expressioni

Gene expression databases

ExpressionAtlasiQ9SZN1 differential
GenevisibleiQ9SZN1 AT

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c'', d and e).

Protein-protein interaction databases

BioGridi15288, 3 interactors
IntActiQ9SZN1, 1 interactor
STRINGi3702.AT4G38510.5

Structurei

3D structure databases

ProteinModelPortaliQ9SZN1
SMRiQ9SZN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

eggNOGiKOG1351 Eukaryota
COG1156 LUCA
HOGENOMiHOG000165320
InParanoidiQ9SZN1
KOiK02147
PhylomeDBiQ9SZN1

Family and domain databases

HAMAPiMF_00310 ATP_synth_B_arch, 1 hit
InterProiView protein in InterPro
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR005723 ATPase_V1-cplx_bsu
IPR027417 P-loop_NTPase
IPR022879 V-ATPase_su_B/beta
PANTHERiPTHR43389 PTHR43389, 1 hit
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
PIRSFiPIRSF039114 V-ATPsynth_beta/V-ATPase_B, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01040 V-ATPase_V1_B, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q9SZN1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAAENNLEM EGTLEIGMEY RTVSGVAGPL VILEKVKGPK YQEIVNIRLG
60 70 80 90 100
DGTTRRGQVL EVDGEKAVVQ VFEGTSGIDN KYTTVQFTGE VLKTPVSLDM
110 120 130 140 150
LGRIFNGSGK PIDNGPPILP EAYLDISGSS INPSERTYPE EMIQTGISTI
160 170 180 190 200
DVMNSIARGQ KIPLFSAAGL PHNEIAAQIC RQAGLVKRLE KSDNLLEHQE
210 220 230 240 250
DDNFAIVFAA MGVNMETAQF FKRDFEENGS MERVTLFLNL ANDPTIERII
260 270 280 290 300
TPRIALTTAE YLAYECGKHV LVILTDMSSY ADALREVSAA REEVPGRRGY
310 320 330 340 350
PGYMYTDLAT IYERAGRIEG RKGSITQIPI LTMPNDDITH PTPDLTGYIT
360 370 380 390 400
EGQIYIDRQL HNRQIYPPIN VLPSLSRLMK SAIGEGMTRR DHSDVSNQLY
410 420 430 440 450
ANYAIGKDVQ AMKAVVGEEA LSSEDLLYLE FLDKFERKFV AQGAYDTRNI
460 470 480
FQSLDLAWTL LRIFPRELLH RIPAKTLDQF YSRDTTN
Length:487
Mass (Da):54,305
Last modified:May 1, 2000 - v1
Checksum:i170224B66A22F1F1
GO

Sequence cautioni

The sequence AAK73967 differs from that shown. Reason: Frameshift at position 43.Curated
The sequence BAD95251 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37K → R in BAH19957 (PubMed:19423640).Curated1
Sequence conflicti330I → F in BAH19957 (PubMed:19423640).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035540 Genomic DNA Translation: CAB37507.1
AL161593 Genomic DNA Translation: CAB80515.1
CP002687 Genomic DNA Translation: AEE86936.1
CP002687 Genomic DNA Translation: AEE86937.1
CP002687 Genomic DNA Translation: AEE86938.1
CP002687 Genomic DNA Translation: AEE86939.1
AY039518 mRNA Translation: AAK62575.1
AY045609 mRNA Translation: AAK73967.1 Frameshift.
AY059167 mRNA Translation: AAL15392.1
AY090334 mRNA Translation: AAL90995.1
AK317281 mRNA Translation: BAH19957.1
AK317596 mRNA Translation: BAH20260.1
AK222158 mRNA Translation: BAD95251.1 Different initiation.
PIRiT05679
RefSeqiNP_001031807.1, NM_001036730.2 [Q9SZN1-1]
NP_001031808.1, NM_001036731.2 [Q9SZN1-1]
NP_195563.1, NM_120012.4 [Q9SZN1-1]
NP_974707.1, NM_202978.2 [Q9SZN1-1]
UniGeneiAt.48961
At.71095

Genome annotation databases

EnsemblPlantsiAT4G38510.1; AT4G38510.1; AT4G38510 [Q9SZN1-1]
AT4G38510.2; AT4G38510.2; AT4G38510 [Q9SZN1-1]
AT4G38510.3; AT4G38510.3; AT4G38510 [Q9SZN1-1]
AT4G38510.4; AT4G38510.4; AT4G38510 [Q9SZN1-1]
AT4G38510.5; AT4G38510.5; AT4G38510
GeneIDi830008
GrameneiAT4G38510.1; AT4G38510.1; AT4G38510 [Q9SZN1-1]
AT4G38510.2; AT4G38510.2; AT4G38510 [Q9SZN1-1]
AT4G38510.3; AT4G38510.3; AT4G38510 [Q9SZN1-1]
AT4G38510.4; AT4G38510.4; AT4G38510 [Q9SZN1-1]
AT4G38510.5; AT4G38510.5; AT4G38510
KEGGiath:AT4G38510

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVATB2_ARATH
AccessioniPrimary (citable) accession number: Q9SZN1
Secondary accession number(s): B9DGU0
, B9DHP3, Q56W88, Q94AY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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