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Q9SZ92

- CK3_ARATH

UniProt

Q9SZ92 - CK3_ARATH

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Protein

Probable choline kinase 3

Gene

At4g09760

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in phospholipid biosynthesis. Catalyzes the first step in phosphatidylcholine biosynthesis (By similarity).By similarity

Catalytic activityi

ATP + choline = ADP + phosphocholine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei71 – 711ATPBy similarity
Binding sitei207 – 2071ATPBy similarity
Binding sitei224 – 2241ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. choline kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT4G09760-MONOMER.
ARA:GQT-1965-MONOMER.
ReactomeiREACT_187678. Synthesis of PE.
REACT_190860. Synthesis of PC.
UniPathwayiUPA00753; UER00737.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable choline kinase 3 (EC:2.7.1.32)
Gene namesi
Ordered Locus Names:At4g09760
ORF Names:F17A8.110
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 4

Organism-specific databases

TAIRiAT4G09760.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Probable choline kinase 3PRO_0000423348Add
BLAST

Proteomic databases

PRIDEiQ9SZ92.

Expressioni

Inductioni

By wounding, and salt and osmotic stresses.1 Publication

Gene expression databases

ExpressionAtlasiQ9SZ92. baseline and differential.
GenevestigatoriQ9SZ92.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G09760.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9SZ92.
SMRiQ9SZ92. Positions 36-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the choline/ethanolamine kinase family.Curated

Phylogenomic databases

InParanoidiQ9SZ92.
KOiK14156.
OMAiVSHESID.
PhylomeDBiQ9SZ92.

Family and domain databases

InterProiIPR026712. Cho/Etha_kinase.
IPR011009. Kinase-like_dom.
[Graphical view]
PANTHERiPTHR22603:SF32. PTHR22603:SF32. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q9SZ92-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVGIFGLIP SSSPDELRKI LQALSTKWGD VVEDFESLEV KPMKGAMTNE
60 70 80 90 100
VFMVSWPRKE TNLRCRKLLV RVYGEGVELF FNRDDEIRTF EYVARHGHGP
110 120 130 140 150
TLLGRFAGGR VEEFIHARTL SATDLRDPNI SALVASKLRR FHSIHIPGDR
160 170 180 190 200
IMLIWDRMRT WVGQAKNLCS NEHSTEFGLD DIEDEINLLE QEVNNEQEIG
210 220 230 240 250
FCHNDLQYGN IMIDEETNAI TIIDYEYASY NPIAYDIANH FCEMAADYHS
260 270 280 290 300
NTPHILDYTL YPGEEERRRF ICNYLTSSGE EAREEDIEQL LDDIEKYTLA
310 320 330 340
SHLFWGLWGI ISGYVNKIEF DYIEYSRQRF KQYWLRKPKL LSFFPS
Length:346
Mass (Da):40,351
Last modified:May 1, 2000 - v1
Checksum:iCF5CCA7CF80F5FF7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 674RCRK → QCRN in AAM66047. 1 PublicationCurated
Sequence conflicti151 – 1511I → T in AAM61617. 1 PublicationCurated
Sequence conflicti175 – 1751T → S in AAM61617. 1 PublicationCurated
Sequence conflicti181 – 1833DIE → CID in AAM61617. 1 PublicationCurated
Sequence conflicti219 – 2191A → T in AAM66047. 1 PublicationCurated
Sequence conflicti288 – 2881E → D in AAM61617. 1 PublicationCurated
Sequence conflicti344 – 3441F → Y in AAM61617. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049482 Genomic DNA. Translation: CAB39643.1.
AL161515 Genomic DNA. Translation: CAB78099.1.
CP002687 Genomic DNA. Translation: AEE82792.1.
CP002687 Genomic DNA. Translation: AEE82793.1.
AY085061 mRNA. Translation: AAM61617.1.
AY088512 mRNA. Translation: AAM66047.1.
PIRiT04023.
RefSeqiNP_192714.1. NM_117044.3. [Q9SZ92-1]
NP_849350.1. NM_179019.1. [Q9SZ92-1]
UniGeneiAt.27989.
At.33676.

Genome annotation databases

EnsemblPlantsiAT4G09760.1; AT4G09760.1; AT4G09760. [Q9SZ92-1]
AT4G09760.2; AT4G09760.2; AT4G09760. [Q9SZ92-1]
GeneIDi826564.
KEGGiath:AT4G09760.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049482 Genomic DNA. Translation: CAB39643.1 .
AL161515 Genomic DNA. Translation: CAB78099.1 .
CP002687 Genomic DNA. Translation: AEE82792.1 .
CP002687 Genomic DNA. Translation: AEE82793.1 .
AY085061 mRNA. Translation: AAM61617.1 .
AY088512 mRNA. Translation: AAM66047.1 .
PIRi T04023.
RefSeqi NP_192714.1. NM_117044.3. [Q9SZ92-1 ]
NP_849350.1. NM_179019.1. [Q9SZ92-1 ]
UniGenei At.27989.
At.33676.

3D structure databases

ProteinModelPortali Q9SZ92.
SMRi Q9SZ92. Positions 36-342.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT4G09760.1-P.

Proteomic databases

PRIDEi Q9SZ92.

Protocols and materials databases

DNASUi 826564.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT4G09760.1 ; AT4G09760.1 ; AT4G09760 . [Q9SZ92-1 ]
AT4G09760.2 ; AT4G09760.2 ; AT4G09760 . [Q9SZ92-1 ]
GeneIDi 826564.
KEGGi ath:AT4G09760.

Organism-specific databases

TAIRi AT4G09760.

Phylogenomic databases

InParanoidi Q9SZ92.
KOi K14156.
OMAi VSHESID.
PhylomeDBi Q9SZ92.

Enzyme and pathway databases

UniPathwayi UPA00753 ; UER00737 .
BioCyci ARA:AT4G09760-MONOMER.
ARA:GQT-1965-MONOMER.
Reactomei REACT_187678. Synthesis of PE.
REACT_190860. Synthesis of PC.

Gene expression databases

ExpressionAtlasi Q9SZ92. baseline and differential.
Genevestigatori Q9SZ92.

Family and domain databases

InterProi IPR026712. Cho/Etha_kinase.
IPR011009. Kinase-like_dom.
[Graphical view ]
PANTHERi PTHR22603:SF32. PTHR22603:SF32. 1 hit.
SUPFAMi SSF56112. SSF56112. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Regulation of phosphatidylcholine biosynthesis under salt stress involves choline kinases in Arabidopsis thaliana."
    Tasseva G., Richard L., Zachowski A.
    FEBS Lett. 566:115-120(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiCK3_ARATH
AccessioniPrimary (citable) accession number: Q9SZ92
Secondary accession number(s): Q8L9C6, Q8LF42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3