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Protein

Probable choline kinase 3

Gene

At4g09760

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in phospholipid biosynthesis. Catalyzes the first step in phosphatidylcholine biosynthesis (By similarity).By similarity

Catalytic activityi

ATP + choline = ADP + phosphocholine.

Pathwayi: phosphatidylcholine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphocholine from choline.
Proteins known to be involved in this subpathway in this organism are:
  1. Probable choline kinase 2 (At1g74320), Probable choline kinase 3 (At4g09760), Probable choline kinase 1 (CK1)
This subpathway is part of the pathway phosphatidylcholine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphocholine from choline, the pathway phosphatidylcholine biosynthesis and in Phospholipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei71ATPBy similarity1
Binding sitei207ATPBy similarity1
Binding sitei224ATPBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:GQT-1965-MONOMER.
ReactomeiR-ATH-1483191. Synthesis of PC.
R-ATH-1483213. Synthesis of PE.
UniPathwayiUPA00753; UER00737.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable choline kinase 3 (EC:2.7.1.32)
Gene namesi
Ordered Locus Names:At4g09760
ORF Names:F17A8.110
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G09760.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004233481 – 346Probable choline kinase 3Add BLAST346

Proteomic databases

PaxDbiQ9SZ92.
PRIDEiQ9SZ92.

Expressioni

Inductioni

By wounding, and salt and osmotic stresses.1 Publication

Gene expression databases

ExpressionAtlasiQ9SZ92. baseline and differential.
GenevisibleiQ9SZ92. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G09760.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SZ92.
SMRiQ9SZ92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the choline/ethanolamine kinase family.Curated

Phylogenomic databases

eggNOGiKOG2686. Eukaryota.
COG0510. LUCA.
HOGENOMiHOG000041274.
InParanoidiQ9SZ92.
KOiK14156.
OMAiERRRFIC.
OrthoDBiEOG09360D8L.
PhylomeDBiQ9SZ92.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q9SZ92-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVGIFGLIP SSSPDELRKI LQALSTKWGD VVEDFESLEV KPMKGAMTNE
60 70 80 90 100
VFMVSWPRKE TNLRCRKLLV RVYGEGVELF FNRDDEIRTF EYVARHGHGP
110 120 130 140 150
TLLGRFAGGR VEEFIHARTL SATDLRDPNI SALVASKLRR FHSIHIPGDR
160 170 180 190 200
IMLIWDRMRT WVGQAKNLCS NEHSTEFGLD DIEDEINLLE QEVNNEQEIG
210 220 230 240 250
FCHNDLQYGN IMIDEETNAI TIIDYEYASY NPIAYDIANH FCEMAADYHS
260 270 280 290 300
NTPHILDYTL YPGEEERRRF ICNYLTSSGE EAREEDIEQL LDDIEKYTLA
310 320 330 340
SHLFWGLWGI ISGYVNKIEF DYIEYSRQRF KQYWLRKPKL LSFFPS
Length:346
Mass (Da):40,351
Last modified:May 1, 2000 - v1
Checksum:iCF5CCA7CF80F5FF7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64 – 67RCRK → QCRN in AAM66047 (Ref. 3) Curated4
Sequence conflicti151I → T in AAM61617 (Ref. 3) Curated1
Sequence conflicti175T → S in AAM61617 (Ref. 3) Curated1
Sequence conflicti181 – 183DIE → CID in AAM61617 (Ref. 3) Curated3
Sequence conflicti219A → T in AAM66047 (Ref. 3) Curated1
Sequence conflicti288E → D in AAM61617 (Ref. 3) Curated1
Sequence conflicti344F → Y in AAM61617 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049482 Genomic DNA. Translation: CAB39643.1.
AL161515 Genomic DNA. Translation: CAB78099.1.
CP002687 Genomic DNA. Translation: AEE82792.1.
CP002687 Genomic DNA. Translation: AEE82793.1.
AY085061 mRNA. Translation: AAM61617.1.
AY088512 mRNA. Translation: AAM66047.1.
PIRiT04023.
RefSeqiNP_192714.1. NM_117044.3. [Q9SZ92-1]
NP_849350.1. NM_179019.1. [Q9SZ92-1]
UniGeneiAt.27989.
At.33676.

Genome annotation databases

EnsemblPlantsiAT4G09760.1; AT4G09760.1; AT4G09760. [Q9SZ92-1]
AT4G09760.2; AT4G09760.2; AT4G09760. [Q9SZ92-1]
GeneIDi826564.
GrameneiAT4G09760.1; AT4G09760.1; AT4G09760.
AT4G09760.2; AT4G09760.2; AT4G09760.
KEGGiath:AT4G09760.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049482 Genomic DNA. Translation: CAB39643.1.
AL161515 Genomic DNA. Translation: CAB78099.1.
CP002687 Genomic DNA. Translation: AEE82792.1.
CP002687 Genomic DNA. Translation: AEE82793.1.
AY085061 mRNA. Translation: AAM61617.1.
AY088512 mRNA. Translation: AAM66047.1.
PIRiT04023.
RefSeqiNP_192714.1. NM_117044.3. [Q9SZ92-1]
NP_849350.1. NM_179019.1. [Q9SZ92-1]
UniGeneiAt.27989.
At.33676.

3D structure databases

ProteinModelPortaliQ9SZ92.
SMRiQ9SZ92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G09760.1.

Proteomic databases

PaxDbiQ9SZ92.
PRIDEiQ9SZ92.

Protocols and materials databases

DNASUi826564.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G09760.1; AT4G09760.1; AT4G09760. [Q9SZ92-1]
AT4G09760.2; AT4G09760.2; AT4G09760. [Q9SZ92-1]
GeneIDi826564.
GrameneiAT4G09760.1; AT4G09760.1; AT4G09760.
AT4G09760.2; AT4G09760.2; AT4G09760.
KEGGiath:AT4G09760.

Organism-specific databases

TAIRiAT4G09760.

Phylogenomic databases

eggNOGiKOG2686. Eukaryota.
COG0510. LUCA.
HOGENOMiHOG000041274.
InParanoidiQ9SZ92.
KOiK14156.
OMAiERRRFIC.
OrthoDBiEOG09360D8L.
PhylomeDBiQ9SZ92.

Enzyme and pathway databases

UniPathwayiUPA00753; UER00737.
BioCyciARA:GQT-1965-MONOMER.
ReactomeiR-ATH-1483191. Synthesis of PC.
R-ATH-1483213. Synthesis of PE.

Miscellaneous databases

PROiQ9SZ92.

Gene expression databases

ExpressionAtlasiQ9SZ92. baseline and differential.
GenevisibleiQ9SZ92. AT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCK3_ARATH
AccessioniPrimary (citable) accession number: Q9SZ92
Secondary accession number(s): Q8L9C6, Q8LF42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.