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Q9SZ53

- P2C60_ARATH

UniProt

Q9SZ53 - P2C60_ARATH

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Protein

Probable protein phosphatase 2C 60

Gene

At4g31860

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571Manganese 1By similarity
Metal bindingi57 – 571Manganese 2By similarity
Metal bindingi58 – 581Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi272 – 2721Manganese 2By similarity
Metal bindingi320 – 3201Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT4G31860-MONOMER.
ARA:GQT-1483-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 60 (EC:3.1.3.16)
Short name:
AtPP2C60
Gene namesi
Ordered Locus Names:At4g31860
ORF Names:F11C18.60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 4

Organism-specific databases

TAIRiAT4G31860.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Probable protein phosphatase 2C 60PRO_0000367982Add
BLAST

Proteomic databases

PaxDbiQ9SZ53.
PRIDEiQ9SZ53.

Expressioni

Gene expression databases

ExpressionAtlasiQ9SZ53. baseline and differential.
GenevestigatoriQ9SZ53.

Interactioni

Protein-protein interaction databases

BioGridi14601. 2 interactions.
IntActiQ9SZ53. 2 interactions.
MINTiMINT-8390698.

Structurei

3D structure databases

ProteinModelPortaliQ9SZ53.
SMRiQ9SZ53. Positions 1-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 322301PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
InParanoidiQ9SZ53.
KOiK17499.
OMAiHEQLNSE.
PhylomeDBiQ9SZ53.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9SZ53-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGIYLSTPKT DKFSEDGENH KLRYGLSSMQ GWRASMEDAH AAILDLDDNT
60 70 80 90 100
SFLGVYDGHG GKVVSKFCAK YLHQQVLSDE AYAAGDVGTS LQKAFFRMDE
110 120 130 140 150
MMQGQRGWRE LAVLGDKINK FSGMIEGLIW SPRSGDSANK PDAWAFEEGP
160 170 180 190 200
HSDFAGPNSG STACVAVVRD KQLFVANAGD SRCVISRKNQ AYNLSRDHKP
210 220 230 240 250
DLEAEKERIL KAGGFIHAGR VNGSLNLSRA IGDMEFKQNK FLPSEKQIVT
260 270 280 290 300
ASPDVNTVEL CDDDDFLVLA CDGIWDCMTS QQLVDFIHEQ LNSETKLSVV
310 320 330 340 350
CEKVLDRCLA PNTSGGEGCD NMTMILVRFK NPTPSETELK PEASQAEGNH

DEPSSSN
Length:357
Mass (Da):39,203
Last modified:May 1, 2000 - v1
Checksum:i98EE1A09818CA0D3
GO
Isoform 2 (identifier: Q9SZ53-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-357: Missing.

Note: No experimental confirmation available.

Show »
Length:275
Mass (Da):30,237
Checksum:i1A50814E124AC2FE
GO

Sequence cautioni

The sequence BX827528 differs from that shown. Reason: Sequencing errors.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei276 – 35782Missing in isoform 2. 1 PublicationVSP_036775Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL049607 Genomic DNA. Translation: CAB40756.1.
AL161579 Genomic DNA. Translation: CAB79904.1.
CP002687 Genomic DNA. Translation: AEE85968.1.
CP002687 Genomic DNA. Translation: AEE85969.1.
AY057611 mRNA. Translation: AAL14406.1.
AY113024 mRNA. Translation: AAM47332.1.
BX827528 mRNA. No translation available.
PIRiT06308.
RefSeqiNP_194914.1. NM_119336.3. [Q9SZ53-1]
NP_974656.1. NM_202927.2. [Q9SZ53-2]
UniGeneiAt.24222.
At.66570.

Genome annotation databases

EnsemblPlantsiAT4G31860.1; AT4G31860.1; AT4G31860. [Q9SZ53-1]
GeneIDi829315.
KEGGiath:AT4G31860.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL049607 Genomic DNA. Translation: CAB40756.1 .
AL161579 Genomic DNA. Translation: CAB79904.1 .
CP002687 Genomic DNA. Translation: AEE85968.1 .
CP002687 Genomic DNA. Translation: AEE85969.1 .
AY057611 mRNA. Translation: AAL14406.1 .
AY113024 mRNA. Translation: AAM47332.1 .
BX827528 mRNA. No translation available.
PIRi T06308.
RefSeqi NP_194914.1. NM_119336.3. [Q9SZ53-1 ]
NP_974656.1. NM_202927.2. [Q9SZ53-2 ]
UniGenei At.24222.
At.66570.

3D structure databases

ProteinModelPortali Q9SZ53.
SMRi Q9SZ53. Positions 1-330.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 14601. 2 interactions.
IntActi Q9SZ53. 2 interactions.
MINTi MINT-8390698.

Proteomic databases

PaxDbi Q9SZ53.
PRIDEi Q9SZ53.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT4G31860.1 ; AT4G31860.1 ; AT4G31860 . [Q9SZ53-1 ]
GeneIDi 829315.
KEGGi ath:AT4G31860.

Organism-specific databases

TAIRi AT4G31860.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000233896.
InParanoidi Q9SZ53.
KOi K17499.
OMAi HEQLNSE.
PhylomeDBi Q9SZ53.

Enzyme and pathway databases

BioCyci ARA:AT4G31860-MONOMER.
ARA:GQT-1483-MONOMER.

Gene expression databases

ExpressionAtlasi Q9SZ53. baseline and differential.
Genevestigatori Q9SZ53.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 2 hits.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 2 hits.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  4. "Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
    Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
    Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: cv. Columbia.
  5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C60_ARATH
AccessioniPrimary (citable) accession number: Q9SZ53
Secondary accession number(s): Q3E9T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3