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Protein

Receptor protein kinase CLAVATA1

Gene

CLV1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the detection of CLV3 and CLV3-like peptides, that act as extracellular signals regulating meristem maintenance. Acts with CLV3 as a ligand-receptor pair in a signal transduction pathway coordinating growth between adjacent meristematic regions and controlling the balance between meristem cell proliferation and differentiation.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei720ATPPROSITE-ProRule annotation1
Active sitei817Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi698 – 706ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein self-association Source: UniProtKB
  • receptor serine/threonine kinase binding Source: UniProtKB
  • signal transducer, downstream of receptor, with serine/threonine kinase activity Source: TAIR

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 399.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein kinase CLAVATA1 (EC:2.7.11.1)
Gene namesi
Name:CLV1
Ordered Locus Names:At1g75820
ORF Names:T4O12.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRilocus:2204350. AT1G75820.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 638ExtracellularSequence analysisAdd BLAST614
Transmembranei639 – 659HelicalSequence analysisAdd BLAST21
Topological domaini660 – 980CytoplasmicSequence analysisAdd BLAST321

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: TAIR
  • plant-type vacuole Source: CACAO
  • plasma membrane Source: UniProtKB-SubCell
  • plasmodesma Source: CACAO

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000002431725 – 980Receptor protein kinase CLAVATA1Add BLAST956

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi276N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi314N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi348N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi422N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi510N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi558N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi574N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi602N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi631N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei766PhosphotyrosineBy similarity1
Modified residuei804PhosphotyrosineBy similarity1
Modified residuei852PhosphoserineBy similarity1
Modified residuei860PhosphotyrosineBy similarity1
Modified residuei867PhosphotyrosineBy similarity1
Modified residuei868PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9SYQ8.
PRIDEiQ9SYQ8.

Expressioni

Tissue specificityi

In a central region of the shoot and in early flower meristems.

Gene expression databases

ExpressionAtlasiQ9SYQ8. baseline and differential.
GenevisibleiQ9SYQ8. AT.

Interactioni

Subunit structurei

Self-interacts. Interacts with CRN; this interaction is direct. Interacts with CLV3 and CLE2 mature peptides (MCLV3 and CLE2p, respectively) via its extracellular leucine-rich repeat region.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KAPPP460146EBI-1646111,EBI-1646157

GO - Molecular functioni

  • protein self-association Source: UniProtKB
  • receptor serine/threonine kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi29134. 16 interactors.
IntActiQ9SYQ8. 2 interactors.
MINTiMINT-98628.
STRINGi3702.AT1G75820.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SYQ8.
SMRiQ9SYQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati93 – 119LRR 1Add BLAST27
Repeati143 – 167LRR 2Add BLAST25
Repeati168 – 193LRR 3Add BLAST26
Repeati240 – 264LRR 4Add BLAST25
Repeati265 – 288LRR 5Add BLAST24
Repeati289 – 312LRR 6Add BLAST24
Repeati314 – 336LRR 7Add BLAST23
Repeati337 – 360LRR 8Add BLAST24
Repeati361 – 384LRR 9Add BLAST24
Repeati386 – 408LRR 10Add BLAST23
Repeati409 – 432LRR 11Add BLAST24
Repeati455 – 479LRR 12Add BLAST25
Repeati480 – 503LRR 13Add BLAST24
Repeati505 – 527LRR 14Add BLAST23
Repeati528 – 551LRR 15Add BLAST24
Repeati552 – 575LRR 16Add BLAST24
Repeati577 – 600LRR 17Add BLAST24
Repeati675 – 691LRR 18Add BLAST17
Domaini692 – 968Protein kinasePROSITE-ProRule annotationAdd BLAST277

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGYE. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000116551.
InParanoidiQ9SYQ8.
KOiK00924.
OMAiKGCEAWR.
OrthoDBiEOG093601AP.
PhylomeDBiQ9SYQ8.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 6 hits.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SYQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMRLLKTHL LFLHLYLFFS PCFAYTDMEV LLNLKSSMIG PKGHGLHDWI
60 70 80 90 100
HSSSPDAHCS FSGVSCDDDA RVISLNVSFT PLFGTISPEI GMLTHLVNLT
110 120 130 140 150
LAANNFTGEL PLEMKSLTSL KVLNISNNGN LTGTFPGEIL KAMVDLEVLD
160 170 180 190 200
TYNNNFNGKL PPEMSELKKL KYLSFGGNFF SGEIPESYGD IQSLEYLGLN
210 220 230 240 250
GAGLSGKSPA FLSRLKNLRE MYIGYYNSYT GGVPPEFGGL TKLEILDMAS
260 270 280 290 300
CTLTGEIPTS LSNLKHLHTL FLHINNLTGH IPPELSGLVS LKSLDLSINQ
310 320 330 340 350
LTGEIPQSFI NLGNITLINL FRNNLYGQIP EAIGELPKLE VFEVWENNFT
360 370 380 390 400
LQLPANLGRN GNLIKLDVSD NHLTGLIPKD LCRGEKLEML ILSNNFFFGP
410 420 430 440 450
IPEELGKCKS LTKIRIVKNL LNGTVPAGLF NLPLVTIIEL TDNFFSGELP
460 470 480 490 500
VTMSGDVLDQ IYLSNNWFSG EIPPAIGNFP NLQTLFLDRN RFRGNIPREI
510 520 530 540 550
FELKHLSRIN TSANNITGGI PDSISRCSTL ISVDLSRNRI NGEIPKGINN
560 570 580 590 600
VKNLGTLNIS GNQLTGSIPT GIGNMTSLTT LDLSFNDLSG RVPLGGQFLV
610 620 630 640 650
FNETSFAGNT YLCLPHRVSC PTRPGQTSDH NHTALFSPSR IVITVIAAIT
660 670 680 690 700
GLILISVAIR QMNKKKNQKS LAWKLTAFQK LDFKSEDVLE CLKEENIIGK
710 720 730 740 750
GGAGIVYRGS MPNNVDVAIK RLVGRGTGRS DHGFTAEIQT LGRIRHRHIV
760 770 780 790 800
RLLGYVANKD TNLLLYEYMP NGSLGELLHG SKGGHLQWET RHRVAVEAAK
810 820 830 840 850
GLCYLHHDCS PLILHRDVKS NNILLDSDFE AHVADFGLAK FLVDGAASEC
860 870 880 890 900
MSSIAGSYGY IAPEYAYTLK VDEKSDVYSF GVVLLELIAG KKPVGEFGEG
910 920 930 940 950
VDIVRWVRNT EEEITQPSDA AIVVAIVDPR LTGYPLTSVI HVFKIAMMCV
960 970 980
EEEAAARPTM REVVHMLTNP PKSVANLIAF
Length:980
Mass (Da):107,598
Last modified:August 16, 2004 - v3
Checksum:i2B2DC41AFF733B08
GO

Sequence cautioni

The sequence AAF26772 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD94816 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BX815769 differs from that shown. Sequencing errors.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti235P → R in AAB58929 (PubMed:9160749).Curated1
Sequence conflicti235P → R in AAD02501 (PubMed:10080719).Curated1
Sequence conflicti703A → S in AAD02501 (PubMed:10080719).Curated1
Sequence conflicti856G → D in AAD02501 (PubMed:10080719).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96879 Genomic DNA. Translation: AAB58929.1.
AF049870 Genomic DNA. Translation: AAD02501.1.
AC007396 Genomic DNA. Translation: AAF26772.1. Different initiation.
CP002684 Genomic DNA. Translation: AEE35762.1.
BX815769 mRNA. No translation available.
AK221523 mRNA. Translation: BAD94816.1. Sequence problems.
RefSeqiNP_177710.1. NM_106232.4.
UniGeneiAt.25465.

Genome annotation databases

EnsemblPlantsiAT1G75820.1; AT1G75820.1; AT1G75820.
GeneIDi843915.
GrameneiAT1G75820.1; AT1G75820.1; AT1G75820.
KEGGiath:AT1G75820.

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96879 Genomic DNA. Translation: AAB58929.1.
AF049870 Genomic DNA. Translation: AAD02501.1.
AC007396 Genomic DNA. Translation: AAF26772.1. Different initiation.
CP002684 Genomic DNA. Translation: AEE35762.1.
BX815769 mRNA. No translation available.
AK221523 mRNA. Translation: BAD94816.1. Sequence problems.
RefSeqiNP_177710.1. NM_106232.4.
UniGeneiAt.25465.

3D structure databases

ProteinModelPortaliQ9SYQ8.
SMRiQ9SYQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi29134. 16 interactors.
IntActiQ9SYQ8. 2 interactors.
MINTiMINT-98628.
STRINGi3702.AT1G75820.1.

Proteomic databases

PaxDbiQ9SYQ8.
PRIDEiQ9SYQ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G75820.1; AT1G75820.1; AT1G75820.
GeneIDi843915.
GrameneiAT1G75820.1; AT1G75820.1; AT1G75820.
KEGGiath:AT1G75820.

Organism-specific databases

AraportiAT1G75820.
TAIRilocus:2204350. AT1G75820.

Phylogenomic databases

eggNOGiENOG410IGYE. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000116551.
InParanoidiQ9SYQ8.
KOiK00924.
OMAiKGCEAWR.
OrthoDBiEOG093601AP.
PhylomeDBiQ9SYQ8.

Enzyme and pathway databases

BRENDAi2.7.10.2. 399.

Miscellaneous databases

PROiPR:Q9SYQ8.

Gene expression databases

ExpressionAtlasiQ9SYQ8. baseline and differential.
GenevisibleiQ9SYQ8. AT.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF13855. LRR_8. 1 hit.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 6 hits.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCLV1_ARATH
AccessioniPrimary (citable) accession number: Q9SYQ8
Secondary accession number(s): O04380, Q56Y00, Q9LQT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: August 16, 2004
Last modified: May 10, 2017
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.