Reviewed, UniProtKB/Swiss-Prot Q9SYG7 (AL7B4_ARATH)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase family 7 member B4
    EC=1.2.1.3
Alternative name(s):
    Antiquitin-1
    Turgor-responsive ALDH

Gene names

Name:	ALDH7B4
Ordered Locus Names:	At1g54100
ORF Names:	F15I1.19

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD+ + H2O = an acid + NADH. UniProtKB P83402
Subunit structure	Homotetramer By similarity. UniProtKB P83402
Induction	By abscisic acid (ABA) and dehydration in roots and plantlets, and by salt stress in plantlets. Ref.1
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Stress response
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular aldehyde metabolic process Inferred from sequence or structural similarity. Source: UniProtKB oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to abscisic acid stimulus Ref.1 Inferred from expression pattern. Source: TAIR response to desiccation Ref.1 Inferred from expression pattern. Source: TAIR response to salt stress Ref.1 Inferred from expression pattern. Source: TAIR
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 508	508	Aldehyde dehydrogenase family 7 member B4		PRO_0000056495
Regions
	Nucleotide binding	244 – 249	6	NAD By similarity
Sites
	Active site	266	1	Proton acceptor By similarity
	Active site	300	1	Nucleophile By similarity
	Site	165	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9SYG7-1 [UniParc]. Last modified November 15, 2002. Version 3. Checksum: 7690BB8D906B263A	FASTA	508	54,208
	10 20 30 40 50 60 MGSANNEYEF LSEIGLTSHN LGSYVAGKWQ ANGPLVSTLN PANNQPIAQV VEASLEDYEQ 70 80 90 100 110 120 GLKACEEAAK IWMQVTAPKR GDIVRQIGDA LRSKLDYLGR LLSLEMGKIL AEGIGEVQEV 130 140 150 160 170 180 IDMCDFAVGL SRQLNGSVIP SERPNHMMLE MWNPLGIVGV ITAFNFPCAV LGWNACIALV 190 200 210 220 230 240 CGNCVVWKGA PTTPLITIAM TKLVAEVLEK NNLPGAIFTA MCGGAEIGEA IAKDTRIPLV 250 260 270 280 290 300 SFTGSSRVGS MVQQTVNARS GKTLLELSGN NAIIVMDDAD IQLAARSVLF AAVGTAGQRC 310 320 330 340 350 360 TTCRRLLLHE SVYDKVLEQL LTSYKQVKIG NPLEKGTLLG PLHTPESKKN FEKGIEVIKS 370 380 390 400 410 420 QGGKILTGGK AVEGEGNFVE PTIIEISADA AVVKEELFAP VLYVLKFKSF GEAVAINNSV 430 440 450 460 470 480 PQGLSSSIFT RNPENIFRWI GPLGSDCGIV NVNIPTNGAE IGGAFGGEKA TGGGREAGSD 490 500 SWKQYMRRST CTINYGNELP LAQGINFG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Detailed expression analysis of selected genes of the aldehyde dehydrogenase(ALDH) gene superfamily in Arabidopsis thaliana." Kirch H.-H., Schlingensiepen S., Kotchoni S., Sunkar R., Bartels D. Plant Mol. Biol. 57:315-332(2005) [PubMed: 15830124] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
[2]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[5]	"The ALDH gene superfamily of Arabidopsis." Kirch H.-H., Bartels D., Wei Y., Schnable P.S., Wood A.J. Trends Plant Sci. 9:371-377(2004) [PubMed: 15358267] [Abstract] Cited for: NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ584645 mRNA. Translation: CAE48164.1. AC006577 Genomic DNA. Translation: AAD25783.1. AY048242 mRNA. Translation: AAK82504.1. AF378873 mRNA. Translation: AAK55676.1. AY091032 mRNA. Translation: AAM13853.1. AY102145 mRNA. Translation: AAM26712.1. AY117345 mRNA. Translation: AAM51420.1. AK230363 mRNA. Translation: BAF02162.1.
IPI	IPI00521527.
PIR	H96581.
RefSeq	NP_175812.1. NP_849807.1.
UniGene	At.20851 Rra.7836 Rsa.22152 Rsa.5331
3D structure databases
SMR	Q9SYG7. Positions 7-507.
ModBase	Search...
Proteomic databases
PRIDE	Q9SYG7.
Genome annotation databases
GeneID	841849.
GenomeReviews	Gene locus AT1G54100 in contig CT485782_GR.
KEGG	ath:AT1G54100.
NMPDR	fig|3702.1.peg.4920.
Organism-specific databases
TAIR	At1g54100.
Phylogenomic databases
eggNOG	KOG2453.
HOGENOM	HBG752218.
InParanoid	Q9SYG7.
OMA	TQIGRVV.
PhylomeDB	Q9SYG7.
Enzyme and pathway databases
BRENDA	1.2.1.3. 302.
Gene expression databases
ArrayExpress	Q9SYG7.
Genevestigator	Q9SYG7.
GermOnline	AT1G54100. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL7B4_ARATH

Accession

Primary (citable) accession number: Q9SYG7
Secondary accession number(s): Q546B7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	November 15, 2002
Last modified:	February 9, 2010
This is version 72 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)