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Protein

Protein FLOWERING LOCUS T

Gene

FT

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the mobile flower-promoting signal (floral stimulus or florigen). Promotes the transition from vegetative growth to flowering. Required for 'SEPALLATA3' (SEP3) and 'FRUITFULL' (FUL) accumulation in mature rosette leaves. Seems to acts in parallel with 'LEAFY' to induce flowering by regulating 'APETALA1'. Translated in leaves and then transported to the shoot apical meristem where it activates the transcription of several floral meristem identity genes. May play a role in both the autonomous and the long-day flowering pathways.3 Publications

Miscellaneous

Mutagenesis of Tyr-85 to His converts the activator of flowering "FLOWERING LOCUS T" into a "TERMINAL FLOWER 1"-like repressor of flowering.

GO - Molecular functioni

  • phosphatidylethanolamine binding Source: TAIR

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • flower development Source: UniProtKB-KW
  • photoperiodism, flowering Source: TAIR
  • positive regulation of flower development Source: TAIR
  • regulation of flower development Source: TAIR
  • regulation of stomatal movement Source: TAIR

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Flowering

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FLOWERING LOCUS T1 Publication
Gene namesi
Name:FT1 Publication
Ordered Locus Names:At1g65480Imported
ORF Names:F5I14.3Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G65480
TAIRilocus:2034168 AT1G65480

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi84E → K in ft-4; late-flowering. 1
Mutagenesisi85Y → H: Inhibition of terminal flower formation, but weak effect on flowering time. 1 Publication1
Mutagenesisi94P → L in ft-6; late-flowering. 1
Mutagenesisi110N → M: No effect on terminal flower formation. 1 Publication1
Mutagenesisi119R → H in ft-3; late-flowering. 1
Mutagenesisi120V → F: No effect on terminal flower formation. 1 Publication1
Mutagenesisi171G → E in ft-1; late-flowering. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047621 – 175Protein FLOWERING LOCUS TAdd BLAST175

Proteomic databases

PaxDbiQ9SXZ2

Expressioni

Tissue specificityi

Mostly localized in leaves vasculature. Transcripts can move in the phloem from leaves to shoot apex at a velocity between 1.2 and 3.5 mm/h.2 Publications

Developmental stagei

Expression gradually increases with time under both long-day (LD) and short-day (SD) photoperiods. Under LD conditions, expression is first detected on day 4 and plateaued around day 6, preceeding floral commitment around days 9 and 10.

Inductioni

Levels follow a circadian cycle with a progressive accumulation during the day time (PubMed:25343985). By light. Expression is delayed and reduced under SD conditions. Repressed by FLC. Up-Regulated by VOZ1 and/or VOZ2 (PubMed:22904146). Up-regulated by APL/FE (PubMed:26239308). Down-regulated by the H3K36me2 modification at the FT locus produced by the interaction between EFM and JMJ30 (PubMed:25132385). Repressed by MYB56 (PubMed:25343985).5 Publications

Gene expression databases

ExpressionAtlasiQ9SXZ2 baseline and differential
GenevisibleiQ9SXZ2 AT

Interactioni

Subunit structurei

Interacts with FD/BZIP14 and FDP/BZIP27 (PubMed:16099979, PubMed:16099980). Interacts with FTIP1 in phloem companion cells (PubMed:22529749). Interacts with NAKR1 (PubMed:27255839).4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi28080, 17 interactors
IntActiQ9SXZ2, 8 interactors
STRINGi3702.AT1G65480.1

Structurei

Secondary structure

1175
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 11Combined sources4
Helixi14 – 17Combined sources4
Beta strandi28 – 32Combined sources5
Helixi45 – 47Combined sources3
Beta strandi48 – 50Combined sources3
Beta strandi53 – 56Combined sources4
Beta strandi64 – 71Combined sources8
Beta strandi85 – 94Combined sources10
Helixi99 – 101Combined sources3
Beta strandi102 – 106Combined sources5
Beta strandi114 – 116Combined sources3
Beta strandi118 – 126Combined sources9
Beta strandi128 – 130Combined sources3
Beta strandi137 – 139Combined sources3
Helixi144 – 150Combined sources7
Beta strandi157 – 164Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WKPX-ray2.60A/B/C/D1-168[»]
ProteinModelPortaliQ9SXZ2
SMRiQ9SXZ2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9SXZ2

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3346 Eukaryota
COG1881 LUCA
HOGENOMiHOG000237656
InParanoidiQ9SXZ2
KOiK16223
OMAiQLLYPRR
OrthoDBiEOG09360OTL
PhylomeDBiQ9SXZ2

Family and domain databases

CDDicd00866 PEBP_euk, 1 hit
Gene3Di3.90.280.10, 1 hit
InterProiView protein in InterPro
IPR031095 FT
IPR008914 PEBP
IPR036610 PEBP-like_sf
IPR035810 PEBP_euk
IPR001858 Phosphotidylethanolamine-bd_CS
PANTHERiPTHR11362 PTHR11362, 1 hit
PTHR11362:SF21 PTHR11362:SF21, 1 hit
PfamiView protein in Pfam
PF01161 PBP, 1 hit
SUPFAMiSSF49777 SSF49777, 1 hit
PROSITEiView protein in PROSITE
PS01220 PBP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q9SXZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSINIRDPLI VSRVVGDVLD PFNRSITLKV TYGQREVTNG LDLRPSQVQN
60 70 80 90 100
KPRVEIGGED LRNFYTLVMV DPDVPSPSNP HLREYLHWLV TDIPATTGTT
110 120 130 140 150
FGNEIVCYEN PSPTAGIHRV VFILFRQLGR QTVYAPGWRQ NFNTREFAEI
160 170
YNLGLPVAAV FYNCQRESGC GGRRL
Length:175
Mass (Da):19,809
Last modified:December 5, 2001 - v2
Checksum:iE4051B22CE66D508
GO
Isoform Short (identifier: Q9SXZ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-122: GNEIVCYENPSPTAGIHRVVF → AWQANSVCTRVAPELQHSRVC
     123-175: Missing.

Show »
Length:122
Mass (Da):13,742
Checksum:i46AF69FE11997F89
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004543102 – 122GNEIV…HRVVF → AWQANSVCTRVAPELQHSRV C in isoform Short. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_004544123 – 175Missing in isoform Short. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027504 mRNA Translation: BAA77838.1
AB027505 mRNA Translation: BAA77839.1
AF152096 Genomic DNA Translation: AAF03936.1
AC001229 Genomic DNA Translation: AAB60904.1
CP002684 Genomic DNA Translation: AEE34381.1
AY065378 mRNA Translation: AAL38819.1
AY133813 mRNA Translation: AAM91747.1
PIRiT52447
T52448
RefSeqiNP_176726.1, NM_105222.3 [Q9SXZ2-1]
UniGeneiAt.469

Genome annotation databases

EnsemblPlantsiAT1G65480.1; AT1G65480.1; AT1G65480 [Q9SXZ2-1]
GeneIDi842859
GrameneiAT1G65480.1; AT1G65480.1; AT1G65480 [Q9SXZ2-1]
KEGGiath:AT1G65480

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFT_ARATH
AccessioniPrimary (citable) accession number: Q9SXZ2
Secondary accession number(s): O04467
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: December 5, 2001
Last modified: May 23, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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