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Protein

Formate dehydrogenase 1, mitochondrial

Gene

Os06g0486800

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the NAD+-dependent oxidation of formate to carbon dioxide. Involved in the cell stress response.UniRule annotation

Catalytic activityi

Formate + NAD+ = CO2 + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201Substrate; via amide nitrogenUniRule annotation
Binding sitei144 – 1441SubstrateUniRule annotation
Binding sitei145 – 1451NADUniRule annotation
Binding sitei219 – 2191NADUniRule annotation
Binding sitei280 – 2801NAD; via carbonyl oxygenUniRule annotation
Sitei282 – 2821Important for catalytic activityUniRule annotation
Binding sitei306 – 3061NADUniRule annotation
Sitei330 – 3301Important for catalytic activityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi199 – 2002NADUniRule annotation
Nucleotide bindingi254 – 2585NADUniRule annotation
Nucleotide bindingi330 – 3334NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase 1, mitochondrialUniRule annotation (EC:1.2.1.2UniRule annotation)
Short name:
FDH 1UniRule annotation
Alternative name(s):
NAD-dependent formate dehydrogenase 11 PublicationUniRule annotation
Gene namesi
Ordered Locus Names:Os06g0486800, LOC_Os06g29180
ORF Names:P0008F02.23, P0404G03.8
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 6

Subcellular locationi

  • Mitochondrion UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2020Mitochondrion1 PublicationAdd
BLAST
Chaini21 – 376356Formate dehydrogenase 1, mitochondrialPRO_0000007195Add
BLAST

Proteomic databases

PaxDbiQ9SXP2.
PRIDEiQ9SXP2.

Expressioni

Gene expression databases

ExpressionAtlasiQ9SXP2. baseline and differential.
GenevisibleiQ9SXP2. OS.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi39947.LOC_Os06g29180.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SXP2.
SMRiQ9SXP2. Positions 42-372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – 144116CatalyticUniRule annotationAdd
BLAST
Regioni145 – 331187Coenzyme-bindingUniRule annotationAdd
BLAST
Regioni332 – 37544CatalyticUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0069. Eukaryota.
COG1052. LUCA.
HOGENOMiHOG000136703.
InParanoidiQ9SXP2.
OMAiEVTYCNS.
OrthoDBiEOG09360BWJ.

Family and domain databases

CDDicd05302. FDH. 1 hit.
Gene3Di3.40.50.720. 2 hits.
HAMAPiMF_03210. Formate_dehydrogenase. 1 hit.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR033689. FDH_NAD-dep.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SXP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMWRAAAGH LLGRALGSRA AHTSAGSKKI VGVFYKGGEY ADKNPNFVGC
60 70 80 90 100
VEGALGIREW LESKGHHYIV TDDKEGLNSE LEKHIEDMHV LITTPFHPAY
110 120 130 140 150
VSAERIKKAK NLELLLTAGI GSDHIDLPAA AAAGLTVAEV TGSNTVSVAE
160 170 180 190 200
DELMRILILL RNFLPGYQQV VHGEWNVAGI AYRAYDLEGK TVGTVGAGRI
210 220 230 240 250
GRLLLQRLKP FNCNLLYHDR LKIDPELEKE IGAKYEEDLD AMLPKCDVIV
260 270 280 290 300
INTPLTEKTR GMFNKERIAK MKKGVIIVNN ARGAIMDTQA VADACSSGQV
310 320 330 340 350
AGYGGDVWFP QPAPKDHPWR YMPNHAMTPH ISGTTIDAQL RYAAGVKDML
360 370
DRYFKGEDFP VQNYIVKEGQ LASQYQ
Length:376
Mass (Da):41,341
Last modified:March 7, 2006 - v2
Checksum:i9FE964AE572C585B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti316 – 3172DH → GP in BAA77337 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019533 mRNA. Translation: BAA77337.1.
AP003518 Genomic DNA. Translation: BAD37348.1.
AP005656 Genomic DNA. Translation: BAD38299.1.
AP014962 Genomic DNA. Translation: BAS97836.1.
RefSeqiXP_015643973.1. XM_015788487.1.
UniGeneiOs.4156.

Genome annotation databases

EnsemblPlantsiOS06T0486800-01; OS06T0486800-01; OS06G0486800.
GeneIDi4341069.
GrameneiOS06T0486800-01; OS06T0486800-01; OS06G0486800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019533 mRNA. Translation: BAA77337.1.
AP003518 Genomic DNA. Translation: BAD37348.1.
AP005656 Genomic DNA. Translation: BAD38299.1.
AP014962 Genomic DNA. Translation: BAS97836.1.
RefSeqiXP_015643973.1. XM_015788487.1.
UniGeneiOs.4156.

3D structure databases

ProteinModelPortaliQ9SXP2.
SMRiQ9SXP2. Positions 42-372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os06g29180.1.

Proteomic databases

PaxDbiQ9SXP2.
PRIDEiQ9SXP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS06T0486800-01; OS06T0486800-01; OS06G0486800.
GeneIDi4341069.
GrameneiOS06T0486800-01; OS06T0486800-01; OS06G0486800.

Phylogenomic databases

eggNOGiKOG0069. Eukaryota.
COG1052. LUCA.
HOGENOMiHOG000136703.
InParanoidiQ9SXP2.
OMAiEVTYCNS.
OrthoDBiEOG09360BWJ.

Gene expression databases

ExpressionAtlasiQ9SXP2. baseline and differential.
GenevisibleiQ9SXP2. OS.

Family and domain databases

CDDicd05302. FDH. 1 hit.
Gene3Di3.40.50.720. 2 hits.
HAMAPiMF_03210. Formate_dehydrogenase. 1 hit.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR033689. FDH_NAD-dep.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFDH1_ORYSJ
AccessioniPrimary (citable) accession number: Q9SXP2
Secondary accession number(s): Q67U72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.