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Q9SXP2 (FDH1_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate dehydrogenase 1, mitochondrial

EC=1.2.1.2
Alternative name(s):
NAD-dependent formate dehydrogenase 1
Short name=FDH 1
Gene names
Ordered Locus Names:Os06g0486800, LOC_Os06g29180
ORF Names:P0008F02.23, P0404G03.8
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Formate + NAD+ = CO2 + NADH.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2020Mitochondrion Ref.3
Chain21 – 376356Formate dehydrogenase 1, mitochondrial
PRO_0000007195

Regions

Nucleotide binding199 – 2002NAD By similarity
Nucleotide binding280 – 2823NAD By similarity
Nucleotide binding330 – 3334NAD By similarity

Sites

Active site2821 By similarity
Active site3301Proton donor By similarity
Binding site2531NAD; via carbonyl oxygen By similarity
Binding site3061NAD By similarity

Experimental info

Sequence conflict316 – 3172DH → GP in BAA77337. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9SXP2 [UniParc].

Last modified March 7, 2006. Version 2.
Checksum: 9FE964AE572C585B

FASTA37641,341
        10         20         30         40         50         60 
MAMWRAAAGH LLGRALGSRA AHTSAGSKKI VGVFYKGGEY ADKNPNFVGC VEGALGIREW 

        70         80         90        100        110        120 
LESKGHHYIV TDDKEGLNSE LEKHIEDMHV LITTPFHPAY VSAERIKKAK NLELLLTAGI 

       130        140        150        160        170        180 
GSDHIDLPAA AAAGLTVAEV TGSNTVSVAE DELMRILILL RNFLPGYQQV VHGEWNVAGI 

       190        200        210        220        230        240 
AYRAYDLEGK TVGTVGAGRI GRLLLQRLKP FNCNLLYHDR LKIDPELEKE IGAKYEEDLD 

       250        260        270        280        290        300 
AMLPKCDVIV INTPLTEKTR GMFNKERIAK MKKGVIIVNN ARGAIMDTQA VADACSSGQV 

       310        320        330        340        350        360 
AGYGGDVWFP QPAPKDHPWR YMPNHAMTPH ISGTTIDAQL RYAAGVKDML DRYFKGEDFP 

       370 
VQNYIVKEGQ LASQYQ 

« Hide

References

« Hide 'large scale' references
[1]"NAD-dependent formate dehydrogenase."
Shiraishi T., Fukusaki E., Kobayashi A.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[3]"Rice proteome database based on two-dimensional polyacrylamide gel electrophoresis: its status in 2003."
Komatsu S., Kojima K., Suzuki K., Ozaki K., Higo K.
Nucleic Acids Res. 32:D388-D392(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 21-30.
Strain: cv. Nipponbare.
Tissue: Callus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB019533 mRNA. Translation: BAA77337.1.
AP003518 Genomic DNA. Translation: BAD37348.1.
AP005656 Genomic DNA. Translation: BAD38299.1.
RefSeqNP_001057666.1. NM_001064201.1.
UniGeneOs.4156.

3D structure databases

ProteinModelPortalQ9SXP2.
SMRQ9SXP2. Positions 42-372.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING39947.LOC_Os06g29180.1.

Proteomic databases

PaxDbQ9SXP2.
PRIDEQ9SXP2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsOS06T0486800-01; OS06T0486800-01; OS06G0486800.
GeneID4341069.
KEGGosa:4341069.

Organism-specific databases

GrameneQ9SXP2.

Phylogenomic databases

eggNOGCOG1052.
HOGENOMHOG000136703.
KOK00122.
OMAEVTYCNS.
ProtClustDBPLN03139.

Family and domain databases

Gene3D3.40.50.720. 2 hits.
InterProIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_2_OHA_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFDH1_ORYSJ
AccessionPrimary (citable) accession number: Q9SXP2
Secondary accession number(s): Q67U72
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 7, 2006
Last modified: April 16, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations