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Protein

Formate dehydrogenase 1, mitochondrial

Gene

Os06g0486800

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei253 – 2531NAD; via carbonyl oxygenBy similarity
Active sitei282 – 2821By similarity
Binding sitei306 – 3061NADBy similarity
Active sitei330 – 3301Proton donorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi199 – 2002NADBy similarity
Nucleotide bindingi280 – 2823NADBy similarity
Nucleotide bindingi330 – 3334NADBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Formate dehydrogenase 1, mitochondrial (EC:1.2.1.2)
Alternative name(s):
NAD-dependent formate dehydrogenase 1
Short name:
FDH 1
Gene namesi
Ordered Locus Names:Os06g0486800, LOC_Os06g29180
ORF Names:P0008F02.23, P0404G03.8
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763 Componenti: Chromosome 6

Organism-specific databases

GrameneiQ9SXP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2020Mitochondrion1 PublicationAdd
BLAST
Chaini21 – 376356Formate dehydrogenase 1, mitochondrialPRO_0000007195Add
BLAST

Proteomic databases

PaxDbiQ9SXP2.
PRIDEiQ9SXP2.

Expressioni

Gene expression databases

ExpressionAtlasiQ9SXP2. baseline.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os06g29180.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SXP2.
SMRiQ9SXP2. Positions 42-372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1052.
HOGENOMiHOG000136703.
InParanoidiQ9SXP2.
KOiK00122.
OMAiGCRRVEN.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SXP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMWRAAAGH LLGRALGSRA AHTSAGSKKI VGVFYKGGEY ADKNPNFVGC
60 70 80 90 100
VEGALGIREW LESKGHHYIV TDDKEGLNSE LEKHIEDMHV LITTPFHPAY
110 120 130 140 150
VSAERIKKAK NLELLLTAGI GSDHIDLPAA AAAGLTVAEV TGSNTVSVAE
160 170 180 190 200
DELMRILILL RNFLPGYQQV VHGEWNVAGI AYRAYDLEGK TVGTVGAGRI
210 220 230 240 250
GRLLLQRLKP FNCNLLYHDR LKIDPELEKE IGAKYEEDLD AMLPKCDVIV
260 270 280 290 300
INTPLTEKTR GMFNKERIAK MKKGVIIVNN ARGAIMDTQA VADACSSGQV
310 320 330 340 350
AGYGGDVWFP QPAPKDHPWR YMPNHAMTPH ISGTTIDAQL RYAAGVKDML
360 370
DRYFKGEDFP VQNYIVKEGQ LASQYQ
Length:376
Mass (Da):41,341
Last modified:March 7, 2006 - v2
Checksum:i9FE964AE572C585B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti316 – 3172DH → GP in BAA77337 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019533 mRNA. Translation: BAA77337.1.
AP003518 Genomic DNA. Translation: BAD37348.1.
AP005656 Genomic DNA. Translation: BAD38299.1.
RefSeqiNP_001057666.1. NM_001064201.1.
UniGeneiOs.4156.

Genome annotation databases

EnsemblPlantsiOS06T0486800-01; OS06T0486800-01; OS06G0486800.
GeneIDi4341069.
KEGGiosa:4341069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019533 mRNA. Translation: BAA77337.1.
AP003518 Genomic DNA. Translation: BAD37348.1.
AP005656 Genomic DNA. Translation: BAD38299.1.
RefSeqiNP_001057666.1. NM_001064201.1.
UniGeneiOs.4156.

3D structure databases

ProteinModelPortaliQ9SXP2.
SMRiQ9SXP2. Positions 42-372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os06g29180.1.

Proteomic databases

PaxDbiQ9SXP2.
PRIDEiQ9SXP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS06T0486800-01; OS06T0486800-01; OS06G0486800.
GeneIDi4341069.
KEGGiosa:4341069.

Organism-specific databases

GrameneiQ9SXP2.

Phylogenomic databases

eggNOGiCOG1052.
HOGENOMiHOG000136703.
InParanoidiQ9SXP2.
KOiK00122.
OMAiGCRRVEN.

Gene expression databases

ExpressionAtlasiQ9SXP2. baseline.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "NAD-dependent formate dehydrogenase."
    Shiraishi T., Fukusaki E., Kobayashi A.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "Rice proteome database based on two-dimensional polyacrylamide gel electrophoresis: its status in 2003."
    Komatsu S., Kojima K., Suzuki K., Ozaki K., Higo K.
    Nucleic Acids Res. 32:D388-D392(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-30.
    Strain: cv. Nipponbare.
    Tissue: Callus.

Entry informationi

Entry nameiFDH1_ORYSJ
AccessioniPrimary (citable) accession number: Q9SXP2
Secondary accession number(s): Q67U72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 7, 2006
Last modified: January 7, 2015
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.