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Protein

Probable carboxylesterase 2

Gene

CXE2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Carboxylesterase acting on esters with varying acyl chain length.By similarity

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei158 – 1581By similarity
Active sitei254 – 2541By similarity
Active sitei286 – 2861By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Enzyme and pathway databases

BioCyciARA:AT1G47480-MONOMER.

Protein family/group databases

ESTHERiarath-F16N3.25. Plant_carboxylesterase.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable carboxylesterase 2
Alternative name(s):
AtCXE2 (EC:3.1.1.1)
Gene namesi
Name:CXE2
Ordered Locus Names:At1g47480
ORF Names:F16N3.25
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G47480.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Probable carboxylesterase 2PRO_0000402548Add
BLAST

Proteomic databases

PaxDbiQ9SX78.
PRIDEiQ9SX78.

Expressioni

Tissue specificityi

Expressed in roots and flowers.1 Publication

Gene expression databases

GenevisibleiQ9SX78. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G47480.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SX78.
SMRiQ9SX78. Positions 21-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi79 – 813Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity

Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.Curated

Phylogenomic databases

eggNOGiKOG1515. Eukaryota.
COG0657. LUCA.
HOGENOMiHOG000152317.
InParanoidiQ9SX78.
OMAiANISHFM.
PhylomeDBiQ9SX78.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR002168. Lipase_GDXG_HIS_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01173. LIPASE_GDXG_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SX78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESTKKQVSL ELLPWLVVHT DGTVERLAGT EVCPPGLDPI TGVFSKDIII
60 70 80 90 100
EPKTGLSARI YRPFSIQPGQ KIPLMLYFHG GAFLISSTSF PSYHTSLNKI
110 120 130 140 150
VNQANVIAVS VNYRLAPEHP LPTAYEDSWT ALKNIQAINE PWINDYADLD
160 170 180 190 200
SLFLVGDSAG ANISHHLAFR AKQSDQTLKI KGIGMIHPYF WGTQPIGAEI
210 220 230 240 250
KDEARKQMVD GWWEFVCPSE KGSDDPWINP FADGSPDLGG LGCERVMITV
260 270 280 290 300
AEKDILNERG KMYYERLVKS EWKGKVEIME TKEKDHVFHI FEPDCDEAME
310
MVRCLALFIN QVEA
Length:314
Mass (Da):35,255
Last modified:May 1, 2000 - v1
Checksum:iF650CA0F5D2A4BA8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti133 – 1342KN → NT in AAM61103 (Ref. 3) Curated
Sequence conflicti152 – 1521L → I in AAM61103 (Ref. 3) Curated
Sequence conflicti178 – 1781L → V in AAM61103 (Ref. 3) Curated
Sequence conflicti205 – 2051R → M in AAM61103 (Ref. 3) Curated
Sequence conflicti220 – 2201E → K in AAM61103 (Ref. 3) Curated
Sequence conflicti264 – 2641Y → F in AAM61103 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007519 Genomic DNA. Translation: AAD46039.1.
CP002684 Genomic DNA. Translation: AEE32171.1.
AY084535 mRNA. Translation: AAM61103.1.
PIRiA96515.
RefSeqiNP_564507.1. NM_103640.2.
UniGeneiAt.43200.

Genome annotation databases

EnsemblPlantsiAT1G47480.1; AT1G47480.1; AT1G47480.
GeneIDi841155.
GrameneiAT1G47480.1; AT1G47480.1; AT1G47480.
KEGGiath:AT1G47480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007519 Genomic DNA. Translation: AAD46039.1.
CP002684 Genomic DNA. Translation: AEE32171.1.
AY084535 mRNA. Translation: AAM61103.1.
PIRiA96515.
RefSeqiNP_564507.1. NM_103640.2.
UniGeneiAt.43200.

3D structure databases

ProteinModelPortaliQ9SX78.
SMRiQ9SX78. Positions 21-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G47480.1.

Protein family/group databases

ESTHERiarath-F16N3.25. Plant_carboxylesterase.

Proteomic databases

PaxDbiQ9SX78.
PRIDEiQ9SX78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G47480.1; AT1G47480.1; AT1G47480.
GeneIDi841155.
GrameneiAT1G47480.1; AT1G47480.1; AT1G47480.
KEGGiath:AT1G47480.

Organism-specific databases

TAIRiAT1G47480.

Phylogenomic databases

eggNOGiKOG1515. Eukaryota.
COG0657. LUCA.
HOGENOMiHOG000152317.
InParanoidiQ9SX78.
OMAiANISHFM.
PhylomeDBiQ9SX78.

Enzyme and pathway databases

BioCyciARA:AT1G47480-MONOMER.

Miscellaneous databases

PROiQ9SX78.

Gene expression databases

GenevisibleiQ9SX78. AT.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR002168. Lipase_GDXG_HIS_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01173. LIPASE_GDXG_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The carboxylesterase gene family from Arabidopsis thaliana."
    Marshall S.D., Putterill J.J., Plummer K.M., Newcomb R.D.
    J. Mol. Evol. 57:487-500(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiCXE2_ARATH
AccessioniPrimary (citable) accession number: Q9SX78
Secondary accession number(s): Q8LG06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.