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Protein

DNA replication licensing factor MCM3 homolog 2

Gene

ROA2

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for DNA replication and cell proliferation (By similarity). May act as a component of the MCM complex which is the putative replicative helicase of the replication licensing system in eukaryotic cells.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi340 – 347ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processCell cycle, DNA replication
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication licensing factor MCM3 homolog 2 (EC:3.6.4.12)
Alternative name(s):
Replication origin activator 2
Short name:
ROA-2
Gene namesi
Name:ROA2
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Chromosome 6

Organism-specific databases

MaizeGDBi131629

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002929451 – 768DNA replication licensing factor MCM3 homolog 2Add BLAST768

Proteomic databases

PaxDbiQ9SX04
PRIDEiQ9SX04

Expressioni

Gene expression databases

ExpressionAtlasiQ9SX04 differential
GenevisibleiQ9SX04 ZM

Interactioni

Protein-protein interaction databases

STRINGi4577.GRMZM2G100639_P01

Structurei

3D structure databases

ProteinModelPortaliQ9SX04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini290 – 497MCMAdd BLAST208

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi472 – 475Arginine finger4

Sequence similaritiesi

Belongs to the MCM family.Curated

Phylogenomic databases

eggNOGiKOG0479 Eukaryota
COG1241 LUCA
KOiK02541
OMAiYQSKVRE
OrthoDBiEOG093602WH

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR031327 MCM
IPR008046 Mcm3
IPR018525 MCM_CS
IPR001208 MCM_dom
IPR027925 MCM_N
IPR033762 MCM_OB
IPR012340 NA-bd_OB-fold
IPR027417 P-loop_NTPase
PANTHERiPTHR11630 PTHR11630, 1 hit
PfamiView protein in Pfam
PF00493 MCM, 1 hit
PF14551 MCM_N, 1 hit
PF17207 MCM_OB, 1 hit
PRINTSiPR01657 MCMFAMILY
PR01659 MCMPROTEIN3
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00350 MCM, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00847 MCM_1, 1 hit
PS50051 MCM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9SX04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEINEEAMAA HKRAFLDFLD QDVGKGVYMQ AVRDMVQNKR HRLIIGMDDL
60 70 80 90 100
RNHNLDLARR VIRTPGEYMQ PASDAVSEVA RNLDPKFLKE GERVMVGFSG
110 120 130 140 150
PFGFHRVTPR DLMSSFIGTM VCVEGIVTKC SLVRPKVVKS VHFCPVTGDF
160 170 180 190 200
LSREYRDITS FVGLPTGSVY PTRDDNGNLL VTEYGMCEYK DHQTLSMQEV
210 220 230 240 250
PENSAPGQLP RTVDVIVEDD LVDCCKPGDR VSIVGVYKAL PGKSKGSVSG
260 270 280 290 300
VFRTVLIANN VSLLNKEANA PVYTREDLKR MKEISRRNDT FDLLGNSLAP
310 320 330 340 350
SIYGHLWIKK AVVLLMLGGV EKNLKNGTHL RGDINMMMVG DPSVAKSQLL
360 370 380 390 400
RAVMNIAPLA ISTTGRGSSG VGLTAAVTSD QETGERRLEA GAMVLADRGV
410 420 430 440 450
VCIDEFDKMN DQDRVAIHEV MEQQTVTIAK AGIHASLNAR CSVIAAANPI
460 470 480 490 500
YGTYDRSLTP TKNIGLPDSL LSRFDLLFIV LDQMDPEIDR QISEHVARMH
510 520 530 540 550
RYCTDDGGAR SLDKEGYAEE DDGDANAAIF VKYDRMLHGQ DRRRGKKSKQ
560 570 580 590 600
DRLTVKFLKK YIHYAKNLIQ PRLTDEASDH IATSYAELRD GSANAKSGGG
610 620 630 640 650
TLPITARTLE TIIRLSTAHA KMKLRHEVLK SDVEAALQVL NFAIYHKELT
660 670 680 690 700
EMEEREQREM EMKQQADHDA GATGGTVDGH GSSGNDPMDV DVGSNDQNVS
710 720 730 740 750
AERIEAFEAL LGQHVLANHI DQMSIDDIEQ MVNRESTAPY TRSQVEFILE
760
RMQDANRVMI RDGVVRII
Length:768
Mass (Da):85,196
Last modified:May 1, 2000 - v1
Checksum:iA82ACAC0BD7B64E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073330 mRNA Translation: AAD48086.1
RefSeqiNP_001105718.1, NM_001112248.2
UniGeneiZm.138412
Zm.174

Genome annotation databases

EnsemblPlantsiZm00001d038467_T002; Zm00001d038467_P002; Zm00001d038467
GeneIDi542738
GrameneiZm00001d038467_T002; Zm00001d038467_P002; Zm00001d038467
KEGGizma:542738

Similar proteinsi

Entry informationi

Entry nameiMCM32_MAIZE
AccessioniPrimary (citable) accession number: Q9SX04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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