UniProtKB - Q9SX04 (MCM32_MAIZE)
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Protein
DNA replication licensing factor MCM3 homolog 2
Gene
ROA2
Organism
Zea mays (Maize)
Status
Functioni
Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for DNA replication and cell proliferation (By similarity). May act as a component of the MCM complex which is the putative replicative helicase of the replication licensing system in eukaryotic cells.By similarity
Catalytic activityi
ATP + H2O = ADP + phosphate.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 340 – 347 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- helicase activity Source: UniProtKB-KW
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- DNA replication initiation Source: InterPro
Keywordsi
Molecular function | DNA-binding, Helicase, Hydrolase |
Biological process | Cell cycle, DNA replication |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: DNA replication licensing factor MCM3 homolog 2 (EC:3.6.4.12)Alternative name(s): Replication origin activator 2 Short name: ROA-2 |
Gene namesi | Name:ROA2 |
Organismi | Zea mays (Maize) |
Taxonomic identifieri | 4577 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogonodae › Andropogoneae › Tripsacinae › Zea |
Proteomesi |
|
Organism-specific databases
MaizeGDBi | 131629. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000292945 | 1 – 768 | DNA replication licensing factor MCM3 homolog 2Add BLAST | 768 |
Proteomic databases
PaxDbi | Q9SX04. |
PRIDEi | Q9SX04. |
Expressioni
Gene expression databases
ExpressionAtlasi | Q9SX04. baseline and differential. |
Genevisiblei | Q9SX04. ZM. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 290 – 497 | MCMAdd BLAST | 208 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 472 – 475 | Arginine finger | 4 |
Sequence similaritiesi
Belongs to the MCM family.Curated
Phylogenomic databases
eggNOGi | KOG0479. Eukaryota. COG1241. LUCA. |
KOi | K02541. |
OMAi | YQSKVRE. |
OrthoDBi | EOG093602WH. |
Family and domain databases
InterProi | View protein in InterPro IPR003593. AAA+_ATPase. IPR031327. MCM. IPR008046. Mcm3. IPR018525. MCM_CS. IPR001208. MCM_dom. IPR027925. MCM_N. IPR033762. MCM_OB. IPR012340. NA-bd_OB-fold. IPR027417. P-loop_NTPase. |
PANTHERi | PTHR11630. PTHR11630. 1 hit. |
Pfami | View protein in Pfam PF00493. MCM. 1 hit. PF14551. MCM_N. 1 hit. PF17207. MCM_OB. 1 hit. |
PRINTSi | PR01657. MCMFAMILY. PR01659. MCMPROTEIN3. |
SMARTi | View protein in SMART SM00382. AAA. 1 hit. SM00350. MCM. 1 hit. |
SUPFAMi | SSF50249. SSF50249. 1 hit. SSF52540. SSF52540. 2 hits. |
PROSITEi | View protein in PROSITE PS00847. MCM_1. 1 hit. PS50051. MCM_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q9SX04-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEINEEAMAA HKRAFLDFLD QDVGKGVYMQ AVRDMVQNKR HRLIIGMDDL
60 70 80 90 100
RNHNLDLARR VIRTPGEYMQ PASDAVSEVA RNLDPKFLKE GERVMVGFSG
110 120 130 140 150
PFGFHRVTPR DLMSSFIGTM VCVEGIVTKC SLVRPKVVKS VHFCPVTGDF
160 170 180 190 200
LSREYRDITS FVGLPTGSVY PTRDDNGNLL VTEYGMCEYK DHQTLSMQEV
210 220 230 240 250
PENSAPGQLP RTVDVIVEDD LVDCCKPGDR VSIVGVYKAL PGKSKGSVSG
260 270 280 290 300
VFRTVLIANN VSLLNKEANA PVYTREDLKR MKEISRRNDT FDLLGNSLAP
310 320 330 340 350
SIYGHLWIKK AVVLLMLGGV EKNLKNGTHL RGDINMMMVG DPSVAKSQLL
360 370 380 390 400
RAVMNIAPLA ISTTGRGSSG VGLTAAVTSD QETGERRLEA GAMVLADRGV
410 420 430 440 450
VCIDEFDKMN DQDRVAIHEV MEQQTVTIAK AGIHASLNAR CSVIAAANPI
460 470 480 490 500
YGTYDRSLTP TKNIGLPDSL LSRFDLLFIV LDQMDPEIDR QISEHVARMH
510 520 530 540 550
RYCTDDGGAR SLDKEGYAEE DDGDANAAIF VKYDRMLHGQ DRRRGKKSKQ
560 570 580 590 600
DRLTVKFLKK YIHYAKNLIQ PRLTDEASDH IATSYAELRD GSANAKSGGG
610 620 630 640 650
TLPITARTLE TIIRLSTAHA KMKLRHEVLK SDVEAALQVL NFAIYHKELT
660 670 680 690 700
EMEEREQREM EMKQQADHDA GATGGTVDGH GSSGNDPMDV DVGSNDQNVS
710 720 730 740 750
AERIEAFEAL LGQHVLANHI DQMSIDDIEQ MVNRESTAPY TRSQVEFILE
760
RMQDANRVMI RDGVVRII
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF073330 mRNA. Translation: AAD48086.1. |
RefSeqi | NP_001105718.1. NM_001112248.2. |
UniGenei | Zm.138412. Zm.174. |
Genome annotation databases
EnsemblPlantsi | Zm00001d038467_T002; Zm00001d038467_P002; Zm00001d038467. |
GeneIDi | 542738. |
Gramenei | Zm00001d038467_T002; Zm00001d038467_P002; Zm00001d038467. |
KEGGi | zma:542738. |
Similar proteinsi
Entry informationi
Entry namei | MCM32_MAIZE | |
Accessioni | Q9SX04Primary (citable) accession number: Q9SX04 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 12, 2007 |
Last sequence update: | May 1, 2000 | |
Last modified: | March 28, 2018 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |