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Protein

Glutathione gamma-glutamylcysteinyltransferase 1

Gene

PCS1

Organism
Triticum aestivum (Wheat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the synthesis of phytochelatins (PC) and homophytochelatins (hPC), the heavy-metal-binding peptides of plants.1 Publication

Catalytic activityi

Glutathione + (Glu(-Cys))(n)-Gly = Gly + (Glu(-Cys))(n+1)-Gly.PROSITE-ProRule annotation

Enzyme regulationi

Requires cadmium for activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei56PROSITE-ProRule annotation1
Active sitei162PROSITE-ProRule annotation1
Active sitei180PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
LigandCadmium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16321

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione gamma-glutamylcysteinyltransferase 1 (EC:2.3.2.15)
Alternative name(s):
Cadmium tolerance protein
Phytochelatin synthase 1
TaPCS1
Gene namesi
Name:PCS1
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeTriticinaeTriticum
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002872121 – 500Glutathione gamma-glutamylcysteinyltransferase 1Add BLAST500

Proteomic databases

PRIDEiQ9SWW5

Expressioni

Tissue specificityi

Expressed in roots and shoots.1 Publication

Inductioni

5- to 10-fold by 100 µM cadmium.1 Publication

Gene expression databases

ExpressionAtlasiQ9SWW5 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ9SWW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 221Peptidase C83PROSITE-ProRule annotationAdd BLAST221

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi333 – 338Poly-Ser6

Sequence similaritiesi

Belongs to the phytochelatin synthase family.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.90.70.30, 1 hit
InterProiView protein in InterPro
IPR007719 PCS_N
IPR038156 PCS_N_sf
IPR015407 Phytochelatin_synthase_C
PfamiView protein in Pfam
PF05023 Phytochelatin, 1 hit
PF09328 Phytochelatin_C, 1 hit
PROSITEiView protein in PROSITE
PS51443 PCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9SWW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVASLYRRV LPSPPAVEFA SAEGKRLFAE ALQGGTMEGF FNLISYFQTQ
60 70 80 90 100
SEPAFCGLAS LSVVLNALAI DPGRPWKGPW RWFDESMLDC CEPLHKVKAE
110 120 130 140 150
GITFGKVVCL AHCAGARVQS FRADQTTIHD FRAHLTRCAS SQDCHLISSY
160 170 180 190 200
HRSPFKQTGT GHFSPIGGYH AEKDMALILD VARFKYPPHW VPLTLLWDAM
210 220 230 240 250
NTTDEATGLL RGFMLVSRRS SAPSLLYTVS CGHGSWKSMA KYCVEDVPNL
260 270 280 290 300
LKDESLDNVT TLLSRLVESL PANAGDLIKC VIEVRRKEEG ESSLSKEEKE
310 320 330 340 350
RLFLKEKVLQ QIRDTDLFRV VHELQYPKGL CGSCSSSSDE DSLAEIAATV
360 370 380 390 400
CCQGAAFLSG NLVSRDGFCC RETCIKCIEA NGDGLKTVIS GTVVSKGNEQ
410 420 430 440 450
AVDLLLPTSS SKTSLCNSNL KSKIVKYPSS TDVLTVLLLV LQPNTWLGIK
460 470 480 490 500
DENVKAEFQS LVSTDNLPDL LKQEILHLRR QLHYLAGCKG QEACQEPPSP
Length:500
Mass (Da):55,045
Last modified:May 1, 2000 - v1
Checksum:i530B8B55FC46B008
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093752 mRNA Translation: AAD50592.1
UniGeneiTa.232

Entry informationi

Entry nameiPCS1_WHEAT
AccessioniPrimary (citable) accession number: Q9SWW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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