SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9SWW5

- PCS1_WHEAT

UniProt

Q9SWW5 - PCS1_WHEAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glutathione gamma-glutamylcysteinyltransferase 1
Gene
PCS1
Organism
Triticum aestivum (Wheat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the synthesis of phytochelatins (PC) and homophytochelatins (hPC), the heavy-metal-binding peptides of plants.1 Publication

Catalytic activityi

Glutathione + (Glu(-Cys))(n)-Gly = Gly + (Glu(-Cys))(n+1)-Gly.

Enzyme regulationi

Requires cadmium for activity By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561 By similarity
Active sitei162 – 1621 By similarity
Active sitei180 – 1801 By similarity

GO - Molecular functioni

  1. glutathione gamma-glutamylcysteinyltransferase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. phytochelatin biosynthetic process Source: InterPro
  2. response to metal ion Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Cadmium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16321.

Protein family/group databases

MEROPSiC83.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione gamma-glutamylcysteinyltransferase 1 (EC:2.3.2.15)
Alternative name(s):
Cadmium tolerance protein
Phytochelatin synthase 1
TaPCS1
Gene namesi
Name:PCS1
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeTriticum
ProteomesiUP000019116: Unplaced

Organism-specific databases

GrameneiQ9SWW5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Glutathione gamma-glutamylcysteinyltransferase 1
PRO_0000287212Add
BLAST

Expressioni

Tissue specificityi

Expressed in roots and shoots.1 Publication

Inductioni

5- to 10-fold by 100 µM cadmium.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9SWW5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 221221Peptidase C83
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi333 – 3386Poly-Ser

Sequence similaritiesi

Family and domain databases

InterProiIPR007719. Phytochelatin_synthase.
IPR015407. Phytochelatin_synthase_C.
[Graphical view]
PfamiPF05023. Phytochelatin. 1 hit.
PF09328. Phytochelatin_C. 1 hit.
[Graphical view]
PROSITEiPS51443. PCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SWW5-1 [UniParc]FASTAAdd to Basket

« Hide

MEVASLYRRV LPSPPAVEFA SAEGKRLFAE ALQGGTMEGF FNLISYFQTQ    50
SEPAFCGLAS LSVVLNALAI DPGRPWKGPW RWFDESMLDC CEPLHKVKAE 100
GITFGKVVCL AHCAGARVQS FRADQTTIHD FRAHLTRCAS SQDCHLISSY 150
HRSPFKQTGT GHFSPIGGYH AEKDMALILD VARFKYPPHW VPLTLLWDAM 200
NTTDEATGLL RGFMLVSRRS SAPSLLYTVS CGHGSWKSMA KYCVEDVPNL 250
LKDESLDNVT TLLSRLVESL PANAGDLIKC VIEVRRKEEG ESSLSKEEKE 300
RLFLKEKVLQ QIRDTDLFRV VHELQYPKGL CGSCSSSSDE DSLAEIAATV 350
CCQGAAFLSG NLVSRDGFCC RETCIKCIEA NGDGLKTVIS GTVVSKGNEQ 400
AVDLLLPTSS SKTSLCNSNL KSKIVKYPSS TDVLTVLLLV LQPNTWLGIK 450
DENVKAEFQS LVSTDNLPDL LKQEILHLRR QLHYLAGCKG QEACQEPPSP 500
Length:500
Mass (Da):55,045
Last modified:May 1, 2000 - v1
Checksum:i530B8B55FC46B008
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF093752 mRNA. Translation: AAD50592.1.
UniGeneiTa.232.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF093752 mRNA. Translation: AAD50592.1 .
UniGenei Ta.232.

3D structure databases

ProteinModelPortali Q9SWW5.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C83.002.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei Q9SWW5.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-16321.

Family and domain databases

InterProi IPR007719. Phytochelatin_synthase.
IPR015407. Phytochelatin_synthase_C.
[Graphical view ]
Pfami PF05023. Phytochelatin. 1 hit.
PF09328. Phytochelatin_C. 1 hit.
[Graphical view ]
PROSITEi PS51443. PCS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Tolerance to toxic metals by a gene family of phytochelatin synthases from plants and yeast."
    Clemens S., Kim E.J., Neumann D., Schroeder J.I.
    EMBO J. 18:3325-3333(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION BY CADMIUM, TISSUE SPECIFICITY.
    Tissue: Root.

Entry informationi

Entry nameiPCS1_WHEAT
AccessioniPrimary (citable) accession number: Q9SWW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi