Reviewed,
UniProtKB/Swiss-Prot Q9SWG0 (IVD_ARATH)
Last modified
June 16, 2009.
Version 74.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Isovaleryl-CoA dehydrogenase, mitochondrial Short name=IVD EC=1.3.99.10 | ||||||
| Gene names |
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| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 409 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor. |
| Cofactor | FAD. UniProtKB P26440 |
| Pathway | Amino-acid degradation; L-leucine degradation; HMG-CoA from 3-isovaleryl-CoA: step 1/3. |
| Subunit structure | Homodimer By similarity. UniProtKB Q9FS87 |
| Subcellular location | |
| Sequence similarities | Belongs to the acyl-CoA dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | FAD Flavoprotein |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrial matrix Inferred from direct assay. Source: TAIR |
| Molecular function | ATP binding Inferred from direct assay. Source: TAIR FAD bindingInferred from electronic annotation. Source: InterPro electron carrier activityInferred from electronic annotation. Source: InterPro isovaleryl-CoA dehydrogenase activityInferred from direct assay. Source: TAIR |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 25 | 25 | Mitochondrion By similarity UniProtKB Q9FS87 | ||||||
| Chain | 26 – 409 | 384 | Isovaleryl-CoA dehydrogenase, mitochondrial UniProtKB Q9FS87 | PRO_0000000535 | |||||
Sites | |||||||||
| Active site | 270 | 1 | Proton acceptor By similarity UniProtKB P26440 | ||||||
Experimental info | |||||||||
| Sequence conflict | 49 | 1 | N → I Ref.1 | ||||||
| Sequence conflict | 49 | 1 | N → I Ref.5 | ||||||
| Sequence conflict | 282 | 1 | M → V in AAL32645. Ref.4 | ||||||
| Sequence conflict | 282 | 1 | M → V in AAM91199. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "In plants a putative isovaleryl-CoA-dehydrogenase is located in mitochondria." Daeschner K., Thalheim C., Guha C., Brennicke A., Binder S. Plant Mol. Biol. 39:1275-1282(1999) [PubMed: 10380813] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION. |
| [2] | "Purification, characterization and cloning of isovaleryl-CoA dehydrogenase from higher plant mitochondria." Faivre-Nitschke S.E., Couee I., Vermel M., Grienenberger J.-M., Gualberto J.M. Eur. J. Biochem. 268:1332-1339(2001) [PubMed: 11231285] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT. Strain: cv. Columbia. |
| [3] | "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana." Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. Tabata S.Nature 408:820-822(2000) [PubMed: 11130713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [4] | "Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R.Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [5] | "Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [6] | "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins." Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H. Plant Cell 16:241-256(2004) [PubMed: 14671022] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
Cross-references
Sequence databases | |
|---|---|
| AF160729 mRNA. Translation: AAD45605.1. Y12695 mRNA. Translation: CAA73227.1. AL132953 Genomic DNA. Translation: CAB72479.1. AY062567 mRNA. Translation: AAL32645.1. AY128799 mRNA. Translation: AAM91199.1. AY087286 mRNA. Translation: AAM64839.1. | |
| IPI | IPI00541942. |
| PIR | T47470. |
| RefSeq | NP_190116.1. |
| UniGene | At.428 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IVH based on UniProtKB P26440. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q9SWG0. |
Genome annotation databases | |
| GeneID | 823668. |
| GenomeReviews | Gene locus AT3G45300 in contig BA000014_GR. |
| KEGG | ath:AT3G45300. |
| NMPDR | fig|3702.1.peg.15742. |
Organism-specific databases | |
| GeneFarm | 4384. |
| TAIR | At3g45300. |
Phylogenomic databases | |
| OMA | Q9SWG0. ELFNETR. |
Enzyme and pathway databases | |
| BRENDA | 1.3.99.10. 302. |
Gene expression databases | |
| ArrayExpress | Q9SWG0. |
| GermOnline | AT3G45300. Arabidopsis thaliana. |
Family and domain databases | |
| InterPro | IPR006089. Acyl-CoA_DH_CS. IPR006092. Acyl-CoA_DH_N. IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_M. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view] |
| Gene3D | G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit. |
| Pfam | PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF02771. Acyl-CoA_dh_N. 1 hit. [Graphical view] |
| PROSITE | PS00072. ACYL_COA_DH_1. 1 hit. PS00073. ACYL_COA_DH_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | IVD_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q9SWG0 Secondary accession number(s): Q8W4G7, Q9XFT2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


