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Protein

Methionine--tRNA ligase, cytoplasmic

Gene

At4g13780

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei351ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase, RNA-binding, tRNA-binding
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine--tRNA ligase, cytoplasmicCurated (EC:6.1.1.10Curated)
Alternative name(s):
Methionyl-tRNA synthetaseCurated
Short name:
MetRSCurated
Gene namesi
Ordered Locus Names:At4g13780
ORF Names:F18A5.170
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G13780
TAIRilocus:2119515 AT4G13780

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001392661 – 797Methionine--tRNA ligase, cytoplasmicAdd BLAST797

Proteomic databases

PaxDbiQ9SVN5
PRIDEiQ9SVN5

PTM databases

iPTMnetiQ9SVN5

Expressioni

Gene expression databases

ExpressionAtlasiQ9SVN5 baseline and differential
GenevisibleiQ9SVN5 AT

Interactioni

Protein-protein interaction databases

BioGridi12309, 2 interactors
STRINGi3702.AT4G13780.1

Structurei

3D structure databases

ProteinModelPortaliQ9SVN5
SMRiQ9SVN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini635 – 738tRNA-bindingPROSITE-ProRule annotationAdd BLAST104

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi26 – 36"HIGH" regionCuratedAdd BLAST11
Motifi348 – 352"KMSKS" regionCurated5

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410JTYU Eukaryota
KOG1247 Eukaryota
KOG2241 Eukaryota
COG0073 LUCA
COG0143 LUCA
HOGENOMiHOG000200402
InParanoidiQ9SVN5
KOiK01874
OMAiYMRMAGH
OrthoDBiEOG093602EC
PhylomeDBiQ9SVN5

Family and domain databases

CDDicd00814 MetRS_core, 1 hit
Gene3Di2.20.28.20, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00098 Met_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR023458 Met-tRNA_ligase_1
IPR014758 Met-tRNA_synth
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR033911 MetRS_core
IPR029038 MetRS_Zn
IPR012340 NA-bd_OB-fold
IPR014729 Rossmann-like_a/b/a_fold
IPR002547 tRNA-bd_dom
IPR009080 tRNAsynth_Ia_anticodon-bd
PfamiView protein in Pfam
PF09334 tRNA-synt_1g, 1 hit
PF01588 tRNA_bind, 1 hit
PRINTSiPR01041 TRNASYNTHMET
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50249 SSF50249, 1 hit
SSF57770 SSF57770, 1 hit
TIGRFAMsiTIGR00398 metG, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
PS50886 TRBD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9SVN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDDGKSSPK LPIPGKRNIL ITSALPYVNN VPHLGNIIGC VLSADVYARY
60 70 80 90 100
CRLRGYNAIY ICGTDEYGTA TETKALEENC TPKEICDKYH AIHKEVYDWF
110 120 130 140 150
GISFDKFGRT STPEQTEVCQ AIFNKLWDNK WLSENTMQQL YCDTCKKFLA
160 170 180 190 200
DRLVEGSCPF EGCNYDSARG DQCEKCGKLL NPTELKDPKC KVCQNTPRIR
210 220 230 240 250
DTDHLFIELP LLKDRLEAYI KKTSVTGSWS QNAIQTTNAW LRDGLRQRCI
260 270 280 290 300
TRDLKWGVPV PHEKYKDKVF YVWFDAPIGY VSITSCYTSE WEKWWKNPEN
310 320 330 340 350
VELYQFMGKD NVPFHTVMFP STQLGTEENW TLMKTISVTE YLNYEDGKFS
360 370 380 390 400
KSKGVGVFGN DVKDTNIPVE VWRYYLLTNR PEVSDTSFSW TDLQAKLNGE
410 420 430 440 450
LLSNLGNFVN RVLSFIAKPD NAGYGSVIPD AHDAESHSLT KSLAEKVEKF
460 470 480 490 500
VAEYVEAMEK VKLKQGLKTA MLISSEGNYY LQASQFWKLY KEDKPLCAVV
510 520 530 540 550
IRTAAGLVHL LAQLLEPFMP SFSCEVFKQL NLPPQFSLSD ERGEVLLASR
560 570 580 590 600
PWDILPPSHR IGTPQPLFKE LENDEVARYR EKFAGSQSDR RARDEAANLA
610 620 630 640 650
DQLNKTKLSD AKKQKASSKG GGKPKPQPAA DREITMARLD IRVGKIVKAE
660 670 680 690 700
KHPKADALYV EEIDVGGGEI RTVVSGLVKY IPLEEMQNRM VCVLCNLKPA
710 720 730 740 750
KMRDIVSQAM VLAASSSDGS KVELVEPPKT ANIGERVTFP GFEGEPDDVL
760 770 780 790
NPKKKVWETL LVDLNTKENL VACYKDVPFT TSAGVCKVSS ISNGTIR
Length:797
Mass (Da):89,854
Last modified:May 1, 2000 - v1
Checksum:iB0F523C2E0C1017F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035528 Genomic DNA Translation: CAB36842.1
AL161537 Genomic DNA Translation: CAB78420.1
CP002687 Genomic DNA Translation: AEE83324.1
AY064009 mRNA Translation: AAL36365.1
AY091454 mRNA Translation: AAM14393.1
PIRiT05247
RefSeqiNP_193114.1, NM_117452.5
UniGeneiAt.27407

Genome annotation databases

EnsemblPlantsiAT4G13780.1; AT4G13780.1; AT4G13780
GeneIDi827012
GrameneiAT4G13780.1; AT4G13780.1; AT4G13780
KEGGiath:AT4G13780

Similar proteinsi

Entry informationi

Entry nameiSYMC_ARATH
AccessioniPrimary (citable) accession number: Q9SVN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health