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Protein

Developmentally-regulated G-protein 3

Gene

DRG3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds GDP and GTP, and has low GTPase activity in vitro.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi72 – 798GTPPROSITE-ProRule annotation
Nucleotide bindingi118 – 1225GTPPROSITE-ProRule annotation
Nucleotide bindingi249 – 2524GTPPROSITE-ProRule annotation

GO - Molecular functioni

  • GDP binding Source: TAIR
  • GTPase activity Source: TAIR
  • GTP binding Source: TAIR
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Developmentally-regulated G-protein 3
Short name:
AtDRG3
Alternative name(s):
Developmentally-regulated G-protein 1
Short name:
AtDRG1
Gene namesi
Name:DRG3
Synonyms:DRG1
Ordered Locus Names:At4g39520
ORF Names:F23K16.150
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G39520.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Developmentally-regulated G-protein 3PRO_0000424833Add
BLAST

Proteomic databases

PaxDbiQ9SVA6.
PRIDEiQ9SVA6.

Expressioni

Gene expression databases

GenevisibleiQ9SVA6. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G39520.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SVA6.
SMRiQ9SVA6. Positions 2-368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 291226OBG-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1487. Eukaryota.
COG1163. LUCA.
HOGENOMiHOG000112078.
InParanoidiQ9SVA6.
OMAiKATSFHL.
PhylomeDBiQ9SVA6.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR031167. G_OBG.
IPR031662. GTP-binding_2.
IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF16897. MMR_HSR1_Xtn. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SVA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTIMQKIKE IEDEMAKTQK NKATSHHLGL LKAKLAKLRR DLLAPPTKGG
60 70 80 90 100
GGGAGEGFDV TKSGDSRVGL VGFPSVGKST LLNKLTGTFS EVASYEFTTL
110 120 130 140 150
TCIPGVITYR GAKIQLLDLP GIIEGAKDGK GRGRQVISTA RTCNCILIVL
160 170 180 190 200
DAIKPITHKR LIEKELEGFG IRLNKEPPNL TFRKKDKGGI NLTSTVAVTH
210 220 230 240 250
LDLDTVKAIC GEYRMHNADI TLRYDATADD LIDVIEGSRI YMPCIYAVNK
260 270 280 290 300
IDSITLEELE ILDKLPHYCP VSAHLEWNLD GLLDKIWEYL DLTRIYTKPK
310 320 330 340 350
AMNPDYDDPV ILSSKKRTVE DFCIRIHKDM LKQFKYALVW GSSAKHKPQR
360
VGKEHELEDE DVVQIVKKI
Length:369
Mass (Da):41,144
Last modified:May 1, 2000 - v1
Checksum:i7235DC68F06DADFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078620 Genomic DNA. Translation: CAB44687.1.
AL161595 Genomic DNA. Translation: CAB80615.1.
CP002687 Genomic DNA. Translation: AEE87081.1.
AY035034 mRNA. Translation: AAK59539.1.
PIRiT09368.
RefSeqiNP_195662.1. NM_120112.3.
UniGeneiAt.3445.

Genome annotation databases

EnsemblPlantsiAT4G39520.1; AT4G39520.1; AT4G39520.
GeneIDi830106.
GrameneiAT4G39520.1; AT4G39520.1; AT4G39520.
KEGGiath:AT4G39520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078620 Genomic DNA. Translation: CAB44687.1.
AL161595 Genomic DNA. Translation: CAB80615.1.
CP002687 Genomic DNA. Translation: AEE87081.1.
AY035034 mRNA. Translation: AAK59539.1.
PIRiT09368.
RefSeqiNP_195662.1. NM_120112.3.
UniGeneiAt.3445.

3D structure databases

ProteinModelPortaliQ9SVA6.
SMRiQ9SVA6. Positions 2-368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G39520.1.

Proteomic databases

PaxDbiQ9SVA6.
PRIDEiQ9SVA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G39520.1; AT4G39520.1; AT4G39520.
GeneIDi830106.
GrameneiAT4G39520.1; AT4G39520.1; AT4G39520.
KEGGiath:AT4G39520.

Organism-specific databases

TAIRiAT4G39520.

Phylogenomic databases

eggNOGiKOG1487. Eukaryota.
COG1163. LUCA.
HOGENOMiHOG000112078.
InParanoidiQ9SVA6.
OMAiKATSFHL.
PhylomeDBiQ9SVA6.

Miscellaneous databases

PROiQ9SVA6.

Gene expression databases

GenevisibleiQ9SVA6. AT.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR031167. G_OBG.
IPR031662. GTP-binding_2.
IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF16897. MMR_HSR1_Xtn. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Isolation and identification of phosphatidic acid targets from plants."
    Testerink C., Dekker H.L., Lim Z.-Y., Johns M.K., Holmes A.B., De Koster C.G., Ktistakis N.T., Munnik T.
    Plant J. 39:527-536(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PHOSPHATIDIC ACID, IDENTIFICATION BY MASS SPECTROMETRY.
  5. "Biochemical characterization of Arabidopsis developmentally regulated G-proteins (DRGs)."
    O'Connell A., Robin G., Kobe B., Botella J.R.
    Protein Expr. Purif. 67:88-95(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiDRG3_ARATH
AccessioniPrimary (citable) accession number: Q9SVA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 22, 2014
Last sequence update: May 1, 2000
Last modified: February 17, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

The nomenclature of the 3 Arabidopsis DRG genes is ambiguous; in the literature several gene names have been used for the same protein.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.