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Protein

Protein SGT1 homolog A

Gene

SGT1A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions in R gene-mediated resistance, but participates in a lower extent than SGT1B to RPP5-mediated resistance. Not required for RPM1, RPS2, RPS4 and RPS5-mediated resistance. Probably required for SCF-mediated ubiquitination, by coupling HSP90 to SCF complex for ubiquitination of HSP90 client proteins.1 Publication

GO - Biological processi

  • cellular response to auxin stimulus Source: UniProtKB
  • defense response Source: TAIR
  • innate immune response Source: UniProtKB-KW
  • regulation of defense response to fungus, incompatible interaction Source: UniProtKB
  • ubiquitin-dependent protein catabolic process Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity, Plant defense, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-ATH-844456. The NLRP3 inflammasome.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SGT1 homolog ABy similarity
Short name:
AtSGT1a
Alternative name(s):
Suppressor of G2 allele of SKP1 homolog ABy similarity
Gene namesi
Name:SGT1A
Ordered Locus Names:At4g23570
ORF Names:F9D16.40
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G23570.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: TAIR
  • SCF ubiquitin ligase complex Source: TAIR
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi157Y → A or R: Diminishes the interaction with barley HSP90. 1 Publication1
Mutagenesisi168F → S or R: Diminishes the interaction with barley HSP90. 1 Publication1
Mutagenesisi199Y → A or R: No effect on the interaction with barley HSP90. 1 Publication1
Mutagenesisi220T → A or R: No effect on the interaction with barley HSP90. 1 Publication1
Mutagenesisi221K → E: Diminishes the interaction with barley HSP90. 1 Publication1
Mutagenesisi223E → A or R: Diminishes the interaction with barley HSP90. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004036471 – 350Protein SGT1 homolog AAdd BLAST350

Proteomic databases

PaxDbiQ9SUR9.

Expressioni

Inductioni

By infection with the oomycete H.parasitica (downy mildew) and heat shock.2 Publications

Gene expression databases

GenevisibleiQ9SUR9. AT.

Interactioni

Subunit structurei

Interacts with RAR1. Forms a ternary complex with RAR1 and barley HSP90.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP90Q7XJ808EBI-1778186,EBI-8080730From a different organism.
HSP90-2Q0Q0I72EBI-1778186,EBI-8081141From a different organism.
sspH2A0A0H3NF382EBI-1778186,EBI-10689860From a different organism.

Protein-protein interaction databases

BioGridi13746. 8 interactors.
IntActiQ9SUR9. 7 interactors.
MINTiMINT-232436.
STRINGi3702.AT4G23570.3.

Structurei

Secondary structure

1350
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi152 – 159Combined sources8
Beta strandi162 – 168Combined sources7
Helixi174 – 176Combined sources3
Beta strandi177 – 181Combined sources5
Beta strandi183 – 190Combined sources8
Beta strandi193 – 195Combined sources3
Beta strandi198 – 200Combined sources3
Beta strandi203 – 206Combined sources4
Helixi210 – 212Combined sources3
Beta strandi214 – 217Combined sources4
Beta strandi222 – 231Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JKIX-ray3.30S/T/U151-240[»]
2XCMX-ray2.20C/D150-241[»]
ProteinModelPortaliQ9SUR9.
SMRiQ9SUR9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9SUR9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 35TPR 1Add BLAST34
Repeati37 – 69TPR 2Add BLAST33
Repeati71 – 103TPR 3Add BLAST33
Domaini149 – 238CSPROSITE-ProRule annotationAdd BLAST90
Domaini260 – 350SGSPROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Belongs to the SGT1 family.Curated
Contains 1 CS domain.PROSITE-ProRule annotation
Contains 1 SGS domain.PROSITE-ProRule annotation
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0376. Eukaryota.
KOG1309. Eukaryota.
COG5091. LUCA.
HOGENOMiHOG000248210.
InParanoidiQ9SUR9.
KOiK12795.
OMAiKADIITW.
PhylomeDBiQ9SUR9.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR007699. SGS_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF04969. CS. 1 hit.
PF05002. SGS. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
PS51048. SGS. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9SUR9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKELADKAK EAFVDDDFDV AVDLYSKAID LDPNCAEFFA DRAQAYIKLE
60 70 80 90 100
SFTEAVADAN KAIELDPSLT KAYLRKGTAC MKLEEYRTAK TALEKGASIT
110 120 130 140 150
PSESKFKKLI DECNFLITEE EKDLVQPVPS TLPSSVTAPP VSELDVTPTA
160 170 180 190 200
KYRHEYYQKP EEVVVTVFAK GIPKQNVNID FGEQILSVVI EVPGEDAYYL
210 220 230 240 250
QPRLFGKIIP DKCKYEVLST KIEICLAKAD IITWASLEHG KGPAVLPKPN
260 270 280 290 300
VSSEVSQRPA YPSSKKVKDW DKLEAEVKKQ EKDEKLEGDA ALNKFFREIY
310 320 330 340 350
QNADEDMRRA MSKSFVESNG TVLSTNWQEV GTKTIESTPP DGMELKKWEI
Length:350
Mass (Da):39,225
Last modified:May 1, 2000 - v1
Checksum:iD23DBE83BC8ACFA5
GO
Isoform 2 (identifier: Q9SUR9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-53: T → TA

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:351
Mass (Da):39,296
Checksum:iF03A33908A8B5D9F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti225C → R in AAL33611 (PubMed:11847307).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04039853T → TA in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF439975 mRNA. Translation: AAL33611.1.
AL035394 Genomic DNA. Translation: CAA23023.1.
AL161559 Genomic DNA. Translation: CAB79312.1.
CP002687 Genomic DNA. Translation: AEE84776.1.
CP002687 Genomic DNA. Translation: AEE84777.1.
CP002687 Genomic DNA. Translation: AEE84778.1.
AY063978 mRNA. Translation: AAL36334.1.
AY096395 mRNA. Translation: AAM20035.1.
AJ318020 mRNA. Translation: CAC85267.1.
PIRiT05589.
RefSeqiNP_001031704.1. NM_001036627.2. [Q9SUR9-2]
NP_194088.1. NM_118488.6. [Q9SUR9-1]
NP_849429.1. NM_179098.3. [Q9SUR9-1]
UniGeneiAt.27360.

Genome annotation databases

EnsemblPlantsiAT4G23570.1; AT4G23570.1; AT4G23570. [Q9SUR9-1]
AT4G23570.2; AT4G23570.2; AT4G23570. [Q9SUR9-1]
GeneIDi828457.
GrameneiAT4G23570.1; AT4G23570.1; AT4G23570.
AT4G23570.2; AT4G23570.2; AT4G23570.
KEGGiath:AT4G23570.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF439975 mRNA. Translation: AAL33611.1.
AL035394 Genomic DNA. Translation: CAA23023.1.
AL161559 Genomic DNA. Translation: CAB79312.1.
CP002687 Genomic DNA. Translation: AEE84776.1.
CP002687 Genomic DNA. Translation: AEE84777.1.
CP002687 Genomic DNA. Translation: AEE84778.1.
AY063978 mRNA. Translation: AAL36334.1.
AY096395 mRNA. Translation: AAM20035.1.
AJ318020 mRNA. Translation: CAC85267.1.
PIRiT05589.
RefSeqiNP_001031704.1. NM_001036627.2. [Q9SUR9-2]
NP_194088.1. NM_118488.6. [Q9SUR9-1]
NP_849429.1. NM_179098.3. [Q9SUR9-1]
UniGeneiAt.27360.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JKIX-ray3.30S/T/U151-240[»]
2XCMX-ray2.20C/D150-241[»]
ProteinModelPortaliQ9SUR9.
SMRiQ9SUR9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi13746. 8 interactors.
IntActiQ9SUR9. 7 interactors.
MINTiMINT-232436.
STRINGi3702.AT4G23570.3.

Proteomic databases

PaxDbiQ9SUR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G23570.1; AT4G23570.1; AT4G23570. [Q9SUR9-1]
AT4G23570.2; AT4G23570.2; AT4G23570. [Q9SUR9-1]
GeneIDi828457.
GrameneiAT4G23570.1; AT4G23570.1; AT4G23570.
AT4G23570.2; AT4G23570.2; AT4G23570.
KEGGiath:AT4G23570.

Organism-specific databases

TAIRiAT4G23570.

Phylogenomic databases

eggNOGiKOG0376. Eukaryota.
KOG1309. Eukaryota.
COG5091. LUCA.
HOGENOMiHOG000248210.
InParanoidiQ9SUR9.
KOiK12795.
OMAiKADIITW.
PhylomeDBiQ9SUR9.

Enzyme and pathway databases

ReactomeiR-ATH-844456. The NLRP3 inflammasome.

Miscellaneous databases

EvolutionaryTraceiQ9SUR9.
PROiQ9SUR9.

Gene expression databases

GenevisibleiQ9SUR9. AT.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR007699. SGS_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF04969. CS. 1 hit.
PF05002. SGS. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
PS51048. SGS. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSGT1A_ARATH
AccessioniPrimary (citable) accession number: Q9SUR9
Secondary accession number(s): Q84LL4, Q8W515
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.