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Protein

Cation/H(+) antiporter 17

Gene

CHX17

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Operates as a K+/H+ antiporter that controls K+ acquisition and homeostasis.2 Publications

GO - Molecular functioni

GO - Biological processi

  • potassium ion transport Source: UniProtKB-KW
  • protein targeting to vacuole Source: TAIR
  • regulation of pH Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Protein family/group databases

TCDBi2.A.37.4.2. the monovalent cation:proton antiporter-2 (cpa2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cation/H(+) antiporter 17
Alternative name(s):
Protein CATION/H+ EXCHANGER 17
Short name:
AtCHX17
Gene namesi
Name:CHX17
Ordered Locus Names:At4g23700
ORF Names:F9D16.170
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G23700.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei58 – 75HelicalSequence analysisAdd BLAST18
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Transmembranei374 – 394HelicalSequence analysisAdd BLAST21
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • late endosome Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Decreased K+ content in roots.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003949871 – 820Cation/H(+) antiporter 17Add BLAST820

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei817PhosphoserineCombined sources1
Modified residuei819PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9SUQ7.

PTM databases

iPTMnetiQ9SUQ7.

Expressioni

Tissue specificityi

Predominantly expressed in epidermal and cortical cells of mature roots but also barely detected in leaves.1 Publication

Inductioni

Up-regulated by NaCl, K+ starvation and abscisic acid (ABA). Induced at acidic external pH.1 Publication

Gene expression databases

GenevisibleiQ9SUQ7. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G23700.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SUQ7.
SMRiQ9SUQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1650. Eukaryota.
COG0475. LUCA.
HOGENOMiHOG000131548.
InParanoidiQ9SUQ7.
OMAiMELNERS.
OrthoDBiEOG093603SN.
PhylomeDBiQ9SUQ7.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
[Graphical view]
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SUQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTNGTTCPG PMKATSNGVF QGENPLEHAL PLLILQICIV LLLTRLLAFL
60 70 80 90 100
LRPLRQPRVI AEIVGGILLG PSALGKSTKF INTVFPPKSL TVLDTLANLG
110 120 130 140 150
LIFFLFLVGL ELDPKSLKRT GKRALSIALA GITLPFVLGI GTSFALRSSI
160 170 180 190 200
ADGASKAPFL VFMGVALSIT AFPVLARILA EIKLLTTDIG KIALSAAAVN
210 220 230 240 250
DVAAWILLAL AVALSGEGSS PLTSLWVFLS GCGFVLFCIF VVQPGIKLIA
260 270 280 290 300
KRCPEGEPVN ELYVCCTLGI VLAASFVTDF IGIHALFGAF VIGVIFPKEG
310 320 330 340 350
NFANALVEKV EDLVSGLFLP LYFVSSGLKT NVATIQGAQS WGLLVLVIFN
360 370 380 390 400
ACFGKIIGTV LVSLYCKVPL DQSLALGFLM NTKGLVELIV LNIGKDRGVL
410 420 430 440 450
NDQIFAIMVL MAIFTTFMTT PLVLAVYKPG KSLTKADYKN RTVEETNRSN
460 470 480 490 500
KPLCLMFCFQ SIMNIPTIVN LIEASRGINR KENLSVYAMH LMELSERSSA
510 520 530 540 550
ILMAHKVRRN GLPFWNKDKS ENNSSSSDMV VVAFEAFRRL SRVSVRPMTA
560 570 580 590 600
ISPMATIHED ICQSAERKKT AMVILPFHKH VRLDRTWETT RNDYRWINKK
610 620 630 640 650
VMEESPCSVA ILVDRGLGGT TRVASSDFSL TITVLFFGGN DDREALAFAV
660 670 680 690 700
RMAEHPGISL TVVRFIPSDE FKPENVRIEI TEDQLCSGAT RLIDIEAITE
710 720 730 740 750
LKAKIKEKES SRSNSDSESH IIYEEKIVKC YEEVIEVIKE YSKSNLFLVG
760 770 780 790 800
KSPEGSVASG INVRSDTPEL GPIGNLLTES ESVSTVASVL VVQQYIASRP
810 820
VGISKNVTTE ESLVEDSESP
Length:820
Mass (Da):89,166
Last modified:May 1, 2000 - v1
Checksum:i8701F7E0C415CF4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY926473 mRNA. Translation: AAX49545.1.
AL035394 Genomic DNA. Translation: CAA23036.1.
AL161559 Genomic DNA. Translation: CAB79325.1.
CP002687 Genomic DNA. Translation: AEE84796.1.
PIRiT05602.
RefSeqiNP_194101.1. NM_118501.5.
UniGeneiAt.2564.

Genome annotation databases

EnsemblPlantsiAT4G23700.1; AT4G23700.1; AT4G23700.
GeneIDi828470.
GrameneiAT4G23700.1; AT4G23700.1; AT4G23700.
KEGGiath:AT4G23700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY926473 mRNA. Translation: AAX49545.1.
AL035394 Genomic DNA. Translation: CAA23036.1.
AL161559 Genomic DNA. Translation: CAB79325.1.
CP002687 Genomic DNA. Translation: AEE84796.1.
PIRiT05602.
RefSeqiNP_194101.1. NM_118501.5.
UniGeneiAt.2564.

3D structure databases

ProteinModelPortaliQ9SUQ7.
SMRiQ9SUQ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G23700.1.

Protein family/group databases

TCDBi2.A.37.4.2. the monovalent cation:proton antiporter-2 (cpa2) family.

PTM databases

iPTMnetiQ9SUQ7.

Proteomic databases

PaxDbiQ9SUQ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G23700.1; AT4G23700.1; AT4G23700.
GeneIDi828470.
GrameneiAT4G23700.1; AT4G23700.1; AT4G23700.
KEGGiath:AT4G23700.

Organism-specific databases

TAIRiAT4G23700.

Phylogenomic databases

eggNOGiKOG1650. Eukaryota.
COG0475. LUCA.
HOGENOMiHOG000131548.
InParanoidiQ9SUQ7.
OMAiMELNERS.
OrthoDBiEOG093603SN.
PhylomeDBiQ9SUQ7.

Miscellaneous databases

PROiQ9SUQ7.

Gene expression databases

GenevisibleiQ9SUQ7. AT.

Family and domain databases

InterProiIPR006153. Cation/H_exchanger.
[Graphical view]
PfamiPF00999. Na_H_Exchanger. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHX17_ARATH
AccessioniPrimary (citable) accession number: Q9SUQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Could complement the kha1 deletion phenotypes in S.cerevisiae.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.