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Protein

Syntaxin-43

Gene

SYP43

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Vesicle trafficking protein that functions in the secretory pathway.By similarity

GO - Molecular functioni

GO - Biological processi

  • Golgi organization Source: TAIR
  • intracellular protein transport Source: InterPro
  • protein secretion Source: TAIR
  • vacuolar transport Source: TAIR
  • vesicle docking Source: GO_Central
  • vesicle fusion Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-43
Short name:
AtSYP43
Gene namesi
Name:SYP43
Ordered Locus Names:At3g05710
ORF Names:F18C1.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G05710.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 305305CytoplasmicSequence analysisAdd
BLAST
Transmembranei306 – 32621Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini327 – 3315VesicularSequence analysis

GO - Cellular componenti

  • endosome Source: TAIR
  • Golgi apparatus Source: TAIR
  • integral component of membrane Source: GO_Central
  • SNARE complex Source: GO_Central
  • trans-Golgi network Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Syntaxin-43PRO_0000210260Add
BLAST

Proteomic databases

PaxDbiQ9SUJ1.
PRIDEiQ9SUJ1.

PTM databases

iPTMnetiQ9SUJ1.
SwissPalmiQ9SUJ1.

Expressioni

Gene expression databases

GenevisibleiQ9SUJ1. AT.

Interactioni

Subunit structurei

Part of the t-SNARE complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi5075. 55 interactions.
IntActiQ9SUJ1. 55 interactions.
STRINGi3702.AT3G05710.2.

Structurei

3D structure databases

ProteinModelPortaliQ9SUJ1.
SMRiQ9SUJ1. Positions 226-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini235 – 29763t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili124 – 15431Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0809. Eukaryota.
COG5325. LUCA.
HOGENOMiHOG000190358.
InParanoidiQ9SUJ1.
KOiK08489.
OMAiITKDFRH.
PhylomeDBiQ9SUJ1.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9SUJ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATRNRTLLF RKYRNSLRSV RAPMGSSSSS TLTEHNSLTG AKSGLGPVIE
60 70 80 90 100
MASTSLLNPN RSYAPVSTED PGNSSRGTIT VGLPPDWVDV SEEISVYIQR
110 120 130 140 150
ARTKMAELGK AHAKALMPSF GDGKEDQHQI ETLTQEVTFL LKKSEKQLQR
160 170 180 190 200
LSAAGPSEDS NVRKNVQRSL ATDLQNLSME LRKKQSTYLK RLRLQKEDGA
210 220 230 240 250
DLEMNLNGSR YKAEDDDFDD MVFSEHQMSK IKKSEEISIE REKEIQQVVE
260 270 280 290 300
SVSELAQIMK DLSALVIDQG TIVDRIDYNI QNVASTVDDG LKQLQKAERT
310 320 330
QRQGGMVMCA SVLVILCFIM LVLLILKEIL L
Length:331
Mass (Da):36,981
Last modified:November 21, 2003 - v2
Checksum:i12C14301C2FBB6F9
GO
Isoform 2 (identifier: Q9SUJ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-75: Missing.

Show »
Length:330
Mass (Da):36,894
Checksum:i96C54E4D39FF0A1A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti207 – 2071N → T in AAM91286 (PubMed:14593172).Curated
Sequence conflicti282 – 2821N → I in AAM91286 (PubMed:14593172).Curated
Sequence conflicti304 – 3041G → K in AAM91286 (PubMed:14593172).Curated
Sequence conflicti312 – 3121V → A in AAM65546 (Ref. 5) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei75 – 751Missing in isoform 2. 2 PublicationsVSP_009005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245408 mRNA. Translation: CAB52175.1.
AC011620 Genomic DNA. Translation: AAF26126.1.
CP002686 Genomic DNA. Translation: AEE74282.1.
CP002686 Genomic DNA. Translation: AEE74283.1.
AY099723 mRNA. Translation: AAM20574.1.
AY128886 mRNA. Translation: AAM91286.1.
AY088000 mRNA. Translation: AAM65546.1.
RefSeqiNP_566256.1. NM_111445.4. [Q9SUJ1-2]
NP_850519.1. NM_180188.3. [Q9SUJ1-1]
UniGeneiAt.20438.

Genome annotation databases

EnsemblPlantsiAT3G05710.2; AT3G05710.2; AT3G05710. [Q9SUJ1-1]
GeneIDi819740.
KEGGiath:AT3G05710.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245408 mRNA. Translation: CAB52175.1.
AC011620 Genomic DNA. Translation: AAF26126.1.
CP002686 Genomic DNA. Translation: AEE74282.1.
CP002686 Genomic DNA. Translation: AEE74283.1.
AY099723 mRNA. Translation: AAM20574.1.
AY128886 mRNA. Translation: AAM91286.1.
AY088000 mRNA. Translation: AAM65546.1.
RefSeqiNP_566256.1. NM_111445.4. [Q9SUJ1-2]
NP_850519.1. NM_180188.3. [Q9SUJ1-1]
UniGeneiAt.20438.

3D structure databases

ProteinModelPortaliQ9SUJ1.
SMRiQ9SUJ1. Positions 226-329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi5075. 55 interactions.
IntActiQ9SUJ1. 55 interactions.
STRINGi3702.AT3G05710.2.

PTM databases

iPTMnetiQ9SUJ1.
SwissPalmiQ9SUJ1.

Proteomic databases

PaxDbiQ9SUJ1.
PRIDEiQ9SUJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G05710.2; AT3G05710.2; AT3G05710. [Q9SUJ1-1]
GeneIDi819740.
KEGGiath:AT3G05710.

Organism-specific databases

TAIRiAT3G05710.

Phylogenomic databases

eggNOGiKOG0809. Eukaryota.
COG5325. LUCA.
HOGENOMiHOG000190358.
InParanoidiQ9SUJ1.
KOiK08489.
OMAiITKDFRH.
PhylomeDBiQ9SUJ1.

Miscellaneous databases

PROiQ9SUJ1.

Gene expression databases

GenevisibleiQ9SUJ1. AT.

Family and domain databases

InterProiIPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Vesicle traffic in Arabidopsis thaliana: characterization of AtSNAP33, a novel plant t-SNARE that interacts with syntaxins."
    Gansel X., Sticher L.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  5. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiSYP43_ARATH
AccessioniPrimary (citable) accession number: Q9SUJ1
Secondary accession number(s): Q8L7J6, Q9M9X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: November 21, 2003
Last modified: February 17, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.