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Protein

Phosphatidylinositol 4-phosphate 5-kinase 7

Gene

PIP5K7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G10900-MONOMER.
ReactomeiR-ATH-1660499. Synthesis of PIPs at the plasma membrane.
R-ATH-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-ATH-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 7 (EC:2.7.1.68)
Short name:
AtPIP5K7
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase 7
Diphosphoinositide kinase 7
Short name:
AtP5K2
PtdIns(4)P-5-kinase 7
Gene namesi
Name:PIP5K7
Synonyms:P5K2
Ordered Locus Names:At1g10900
ORF Names:T19D16.18
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G10900.

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854791 – 754Phosphatidylinositol 4-phosphate 5-kinase 7Add BLAST754

Proteomic databases

PaxDbiQ9SUI2.

PTM databases

iPTMnetiQ9SUI2.

Expressioni

Gene expression databases

GenevisibleiQ9SUI2. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G10900.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SUI2.
SMRiQ9SUI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati16 – 38MORN 1Add BLAST23
Repeati39 – 61MORN 2Add BLAST23
Repeati62 – 84MORN 3Add BLAST23
Repeati85 – 107MORN 4Add BLAST23
Repeati108 – 130MORN 5Add BLAST23
Repeati131 – 153MORN 6Add BLAST23
Repeati154 – 176MORN 7Add BLAST23
Repeati177 – 198MORN 8Add BLAST22
Domaini329 – 750PIPKPROSITE-ProRule annotationAdd BLAST422

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni710 – 731Activation loopBy similarityAdd BLAST22

Sequence similaritiesi

Contains 8 MORN repeats.Curated
Contains 1 PIPK domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0229. Eukaryota.
COG4642. LUCA.
COG5253. LUCA.
HOGENOMiHOG000193875.
InParanoidiQ9SUI2.
KOiK00889.
OMAiQDPPNKS.
OrthoDBiEOG0936025Q.
PhylomeDBiQ9SUI2.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 2 hits.
PfamiPF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTiSM00698. MORN. 8 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SUI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMRSGDREF PNGDFYSGEV KGIIPNGKGK YAWSDGTIYE GDWDEGKISG
60 70 80 90 100
KGKLIWSSGA KYEGDFSGGY LHGFGTMTSP DESVYSGAWR MNVRHGLGRK
110 120 130 140 150
EYCNSDLYDG LWKEGLQDGR GSYSWTNGNR YIGNWKKGKM CERGVMRWEN
160 170 180 190 200
GDLYDGFWLN GFRHGSGVYK FADGCLYYGT WSRGLKDGKG VFYPAGTKQP
210 220 230 240 250
SLKKWCRSLE YDDTGKFVLS RSASVNVEEL RSLNTVTQSL SVKTSAGETT
260 270 280 290 300
CDPPRDFTCH GPVSKSARFS GSGQSEGQDK NRIVYEREYM QGVLIRETIM
310 320 330 340 350
SSVDRSHKIK PPNRPREVRA RSLMTFLRGE HNYYLMLNLQ LGIRYTVGKI
360 370 380 390 400
TPVPRREVRA SDFGKNARTK MFFPRDGSNF TPPHKSVDFS WKDYCPMVFR
410 420 430 440 450
NLRQMFKLDA AEYMMSICGD DGLTEISSPG KSGSIFYLSH DDRFVIKTLK
460 470 480 490 500
KSELQVLLRM LPKYYEHVGD HENTLITKFF GVHRITLKWG KKVRFVVMGN
510 520 530 540 550
MFCTELKIHR RYDLKGSTQG RFTEKIKIQE KTTLKDLDLA YEFHMDKLLR
560 570 580 590 600
EALFKQIYLD CSFLESLNII DYSLLLGLHF RAPGQLNDIL EPPNAMSDQE
610 620 630 640 650
SVSSVDVGLT QEHSIPPKGL LLVTHEPNSV NTAPGPHIRG STLRAFSVGE
660 670 680 690 700
QEVDLILPGT ARLRVQLGVN MPAQAHHKLI EDKEESATIE LFEVYDVVVY
710 720 730 740 750
MGIIDILQEY NTKKKVEHTC KSLQYDPMTI SVTEPSTYSK RFVNFLHKVF

PEER
Length:754
Mass (Da):85,955
Last modified:May 1, 2000 - v1
Checksum:iD2310E6AABBA4F00
GO

Sequence cautioni

The sequence AAB65487 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ009782 mRNA. Translation: CAB53377.1.
U95973 Genomic DNA. Translation: AAB65487.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28661.1.
AY062718 mRNA. Translation: AAL32796.1.
BT010342 mRNA. Translation: AAQ56785.1.
PIRiG86242.
RefSeqiNP_172559.2. NM_100965.5.
UniGeneiAt.485.

Genome annotation databases

EnsemblPlantsiAT1G10900.1; AT1G10900.1; AT1G10900.
GeneIDi837633.
GrameneiAT1G10900.1; AT1G10900.1; AT1G10900.
KEGGiath:AT1G10900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ009782 mRNA. Translation: CAB53377.1.
U95973 Genomic DNA. Translation: AAB65487.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28661.1.
AY062718 mRNA. Translation: AAL32796.1.
BT010342 mRNA. Translation: AAQ56785.1.
PIRiG86242.
RefSeqiNP_172559.2. NM_100965.5.
UniGeneiAt.485.

3D structure databases

ProteinModelPortaliQ9SUI2.
SMRiQ9SUI2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G10900.1.

PTM databases

iPTMnetiQ9SUI2.

Proteomic databases

PaxDbiQ9SUI2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G10900.1; AT1G10900.1; AT1G10900.
GeneIDi837633.
GrameneiAT1G10900.1; AT1G10900.1; AT1G10900.
KEGGiath:AT1G10900.

Organism-specific databases

TAIRiAT1G10900.

Phylogenomic databases

eggNOGiKOG0229. Eukaryota.
COG4642. LUCA.
COG5253. LUCA.
HOGENOMiHOG000193875.
InParanoidiQ9SUI2.
KOiK00889.
OMAiQDPPNKS.
OrthoDBiEOG0936025Q.
PhylomeDBiQ9SUI2.

Enzyme and pathway databases

BioCyciARA:AT1G10900-MONOMER.
ReactomeiR-ATH-1660499. Synthesis of PIPs at the plasma membrane.
R-ATH-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-ATH-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

PROiQ9SUI2.

Gene expression databases

GenevisibleiQ9SUI2. AT.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 2 hits.
PfamiPF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTiSM00698. MORN. 8 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPI5K7_ARATH
AccessioniPrimary (citable) accession number: Q9SUI2
Secondary accession number(s): O04095
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.